Highly-antioxidant highly-crosslinked ultra-high molecular weight polyethylene artificial joint material and preparation method thereof

An ultra-high molecular weight, artificial joint technology, applied in the field of high anti-oxidative and high cross-linked ultra-high molecular weight polyethylene artificial joint material and its preparation field, can solve the problems of difficulty in exerting anti-oxidation effect, unfavorable mechanical properties of materials, increased chain breakage, etc. , to achieve the effect of improving antioxidant performance, meeting the conditions of use, and strong antioxidant capacity

Active Publication Date: 2018-03-06
SICHUAN UNIV
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  • Abstract
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  • Application Information

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Problems solved by technology

When the VE content is higher than 0.3 wt%, the crosslinking density and wear rate of the material under high irradiation dose are significantly lower than those of the control sample without VE, and the excessively high irradiation dose will also increase the probability of chain breakage, which is not conducive to the mechanical properties of the material. Performance maintenance; and too low VE addition amount is difficult to exert its antioxidant effect

Method used

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  • Highly-antioxidant highly-crosslinked ultra-high molecular weight polyethylene artificial joint material and preparation method thereof
  • Highly-antioxidant highly-crosslinked ultra-high molecular weight polyethylene artificial joint material and preparation method thereof
  • Highly-antioxidant highly-crosslinked ultra-high molecular weight polyethylene artificial joint material and preparation method thereof

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preparation example Construction

[0033] Specifically, the preparation method of the present invention may include the following steps.

[0034] Step A: Doping UHMWPE with Polyphenolic Antioxidants

[0035] Add ultra-high molecular weight polyethylene (UHMWPE) and polyphenolic antioxidant into isopropanol and keep stirring, and dry the resulting mixture to obtain mixed powder. Among them, polyphenolic antioxidants account for 0.05% to 0.20% of the total mass of ultra-high molecular weight polyethylene and polyphenolic antioxidants. Preferably, the polyphenolic antioxidant accounts for 0.20% of the total mass of ultra-high molecular weight polyethylene and polyphenolic antioxidant.

[0036] According to the present invention, the selected ultra-high molecular weight polyethylene is biomedical grade, and the relative molecular mass is 5 × 10 6 ~6×10 6 g / mol, the density is 0.93 ~ 0.98 g / cm 3 , the particle diameter is 120 ~ 160 μm. The selected polyphenolic antioxidants were epigallocatechin gallate (EGCG...

Embodiment 1

[0047] (1) EGCG doped UHMWPE: UHMWPE and EGCG (where EGCG accounts for 0.20% of the total mass of UHMWPE and EGCG) were added to isopropanol, and the stirring was continued for 3 h to ensure sufficient and uniform dispersion of EGCG in UHMWPE. The above mixture was dried in a vacuum oven at 60 ºC for 7 days to completely remove the isopropanol.

[0048] (2) Compression molding: The obtained EGCG / UHMWPE mixed powder was placed in a mold, and the EGCG / UHMWPE mixed powder was molded at a temperature of 200 ºC and a pressure of 10 MPa, then slowly cooled to room temperature, and a blank was obtained after demoulding.

Embodiment 2

[0050] (1) EGCG doped UHMWPE: UHMWPE and EGCG (where EGCG accounts for 0.20% of the total mass of UHMWPE and EGCG) were added to isopropanol, and the stirring was continued for 3 h to ensure sufficient and uniform dispersion of EGCG in UHMWPE. The above mixture was dried in a vacuum oven at 60 ºC for 7 days to completely remove the isopropanol.

[0051] (2) Compression molding: The obtained EGCG / UHMWPE mixed powder is placed in a mold, and the EGCG / UHMWPE mixed powder is molded at a temperature of 200 ºC and a pressure of 10 MPa, and then slowly cooled to room temperature, and a blank is obtained after demoulding.

[0052] (3) Irradiation crosslinking: At room temperature, the vacuum-packed EGCG / UHMWPE molded blanks were irradiated with a 10 MeV electron beam, and the irradiation dose was 100 kGy.

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Abstract

The invention discloses a highly-antioxidant highly-crosslinked ultra-high molecular weight polyethylene artificial joint material and a preparation method thereof. The artificial joint material is composed of a polyphenol antioxidant epigallocatechin gallate or lipid-soluble epigallocatechin gallate doped biocompatible ultra-high molecular weight polyethylene modified by palmitoyl chloride esterification, and is prepared by irradiation crosslinking after compression molding. The preparation method specifically comprises the following steps: doping the antioxidant with the ultra-high molecularweight polyethylene; performing compression molding; and performing irradiation crosslinking. The oxidation resistance of the irradiation crosslinked ultra-high molecular weight polyethylene is obviously improved under the condition that the crosslinking efficiency is not reduced. Meanwhile, due to the addition of the polyphenol antioxidant, the tensile property and impact strength of the material are not influenced, so that the overall service performance of the joint material is improved, and the service time is prolonged.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and more specifically relates to a high-antioxidation high-crosslinking ultra-high molecular weight polyethylene artificial joint material and a preparation method thereof. Background technique [0002] Ultra-high molecular weight polyethylene (UHMWPE) has become the first choice for artificial joint replacement materials due to its good wear resistance, mechanical properties and biocompatibility. However, during long-term use, the UHMWPE joint material is constantly worn and produces wear debris, which easily stimulates the phagocytosis of macrophages, triggers osteolysis, and leads to loosening and dislocation of the prosthesis, requiring a second revision surgery. Studies have shown that irradiation cross-linking can improve the wear resistance of UHMWPE, but part of the radiation-induced free radicals are trapped in the crystal region, and combine with oxygen during the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/50C08J7/12C08L23/06
CPCA61L27/16A61L27/50A61L2430/24C08J7/123C08J2323/06C08L23/06
Inventor 徐家壮任悦李忠明徐玲
Owner SICHUAN UNIV
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