Method for prediabetes screening

A pre-diabetes and detection method technology, applied in the direction of disease diagnosis, biological testing, measuring devices, etc., can solve the problems of delaying treatment, not implying pre-diabetes, etc., achieve simple detection, prevent the development of diabetes or complications, and reduce symptoms The effect of treatment costs

Inactive Publication Date: 2012-11-21
FUKUOKA UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in fact, less than 3 million people with diabetes receive diabetes treatment, and the number of patients with kidney disease continues to increase by 10,000 people every year due to insufficient diagnosis and delayed treatment.
However, it is neither stated nor implied that the AGE derivative can be used as a diagnostic marker for prediabetes

Method used

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  • Method for prediabetes screening
  • Method for prediabetes screening
  • Method for prediabetes screening

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0172] In this example, a method for producing prediabetic mice will be described.

[0173] 5-week-old C57BL / 6J (hereinafter abbreviated as "B6 mice") were purchased from Japan Charles River Co., Ltd. After the animals arrived, they were brought into the animal breeding room, and under a 12-hour light-dark cycle, they were reared until the target week in an environment where they could freely ingest experimental animal solid feed (Oriental Yeast Co., Ltd.) as feed and tap water as drinking water. age, used for experiments.

Embodiment 2

[0175] The mice were intraperitoneally administered 1 mL / kg body weight of pentobarbital sodium injection for adequate anesthesia, and after body weight was measured, blood was collected from the heart with a heparinized syringe. 1,000 g of the obtained blood was centrifuged at 4° C. for 10 minutes to obtain a plasma sample. Visceral fat was harvested after blood collection and mice were euthanized. The amount of visceral fat collected was measured, and the results were expressed in image 3 middle.

Embodiment 3

[0177] The measurement of the blood glucose level was carried out using a small blood glucose measuring device (glutest sensor, Sanwa Chemical Laboratory Co., Ltd.). The measurement of the insulin level in the blood was carried out using an ultra-high sensitivity mouse insulin measurement kit (Mori Naga Institute of Science). Blood glucose level and blood insulin measurement results are respectively expressed in figure 1 with figure 2 middle.

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Abstract

Provided is a method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay, with which it is possible to treat many samples as simply and as safely as with blood sugar assay, and to collect a blood sample taken during a primary health screening in one procedure without imposing any time restraints, complications or risks on the subject. The method for prediabetes screening by means of methylglyoxal-modified arginine derivative assay comprises assaying the methylglyoxal-modified arginine derivative in blood using an assay system which employs an antibody that specifically recognizes methylglyoxal-modified arginine derivative.

Description

technical field [0001] The invention relates to a detection method for prediabetes. More specifically, the present invention relates to a method for detecting insulin resistance and impaired glucose tolerance, especially prediabetes, by measuring glycosylated proteins as blood markers, and based on this, it is possible to easily detect prediabetes in a health diagnosis stage. The pre-diabetes detection method for diabetes, wherein the glycated protein is an in vivo substance with a pyrimidine structure or an imidazolone structure, including arginine compounds or hydroimidazolone compounds. Background technique [0002] By 2030, the number of diabetic patients worldwide will increase from the current 285 million to more than 400 million, and about 90% of them are obese diabetic patients with lifestyle-related diseases as the main cause. In my country, it is currently estimated that there are more than 10 million obese diabetic patients, and the number of patients is still in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/53C07D239/42
CPCG01N33/6812G01N2800/042C07D239/42
Inventor 渡边俊明
Owner FUKUOKA UNIV
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