Wound healing compositions involving medicinal honey, mineral ions and methylglyoxal, and methods of use

Abstract

The invention provides compositions based on either medicinal honey containing broad spectrum antibacterial activities of peroxide, polyphenols and methylglyoxal, or an effective amount of an active anti-inflammatory ingredient of mineral solids fortified with methylglyoxal antibacterial activity, or a mixture of both for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with any one of the above compositions or a wound dressing containing any one of the above compositions.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation application of and claims priority from U.S. Nonprovisional patent application Ser. No. 15 / 010,896 filed on Jan. 29, 2016, which claims the benefit of U.S. Provisional Patent Application Ser. No. 62 / 109,369, filed Jan. 29, 2015. The foregoing applications are incorporated in their entirety herein by reference.FIELD OF THE INVENTION[0002]The invention broadly relates to wound healing compositions, more specifically to wound healing compositions including various combinations of medicinal honey, methylglyoxal, pharmaceutically acceptable carriers, inorganic minerals with methylglyoxal, salts, and medicinal buckwheat honey.BACKGROUND OF THE INVENTION[0003]Undesirable and dangerous side effects and adverse drug interactions are well known for the predominantly synthetic organic pharmaceuticals that have been widely administered over the past several decades. These adverse effects have led many research group...

AI Technical Summary

Benefits of technology

[0030]All three of the inventive compositions are used in aqueous, ointment, or wound-dressing formulations to modulate biochemical mechanisms associated with wound healing, including decreasing both wound protease activities and active infection.

Problems solved by technology

First, hydrogen peroxide is not a constituent of the nectar from which honey is produced.

Second, the production of hydrogen peroxide is very slow in mature honey for two reasons: i) the activity of glucose oxidase is depressed by high osmotic pressure, and ii) the spontaneous conversion of gluconolactone to glucuronic acid and hydrogen peroxide is a hydrolysis reaction requiring water, which is unavailable in ripe honey.

In addition, the chemical interaction of honey phenolics with hydrogen peroxide results in products that degrade bacterial DNA.

Scarcity of some metal ions often leads to disease.

Heretofore, widely administered synthetic organic pharmaceuticals are commonly associated with undesirable side effects and adverse drug interactions.

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