Wound Healing Composition Involving Mineral Ions and Methylglyoxal, and Methods of Use

Abstract

The invention provides compositions based on an effective amount of an active anti-inflammatory ingredient of mineral solids fortified with methylglyoxal antibacterial activity for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with the above compositions or a wound dressing containing the above compositions.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This patent application is a divisional of and claims priority to currently pending U.S. Nonprovisional application Ser. No. 15 / 010,896, entitled “Wound Healing Compositions Involving Medicinal Honey, Metal Ions, and Methylglyoxal, and Methods of Use,” filed Jan. 29, 2016, which claims the benefit under 35 U.S.C. §119(e) of U.S. Provisional Patent Application No. 62 / 109,369, entitled “Wound Healing Compositions Involving Medicinal Honey, Metal Ions, and Methylglyoxal, and Methods of Use,” filed Jan. 29, 2015, the contents of each of which are hereby incorporated by reference into this disclosure.FIELD OF THE INVENTION[0002]The invention broadly relates to a wound healing composition, more specifically to a wound healing composition including various combinations of inorganic minerals, salts, methylglyoxal, and pharmaceutically acceptable carriers.BACKGROUND OF THE INVENTION[0003]Undesirable and dangerous side effects and adverse drug inte...

AI Technical Summary

Benefits of technology

The invention is a special formula that can be used to create substances like medicine or ointment that can help heal wounds. It can decrease the levels of proteases that help spread infections and make wounds bleed.

Problems solved by technology

Scarcity of some metal ions often leads to disease.

Antimicrobial resistance is an increasing clinical problem precipitated by the inappropriate use of antibiotics in the latter parts of the 20th Century.

This problem, coupled with the lack of novel therapeutics in the development pipeline, means antimicrobial resistance is reaching a crisis point, with an expected annual death rate of ten million people worldwide by 2050.

MGO causes cell disruption to the regular cell division process of S. aureus.

In contrast to the mechanism observed in the gram-positive S. aureus, MGO causes the loss of cellular integrity in the gram-negative P. aeruginosa, leading to extensive cell lysis and cell death.

Heretofore, widely administered synthetic organic pharmaceuticals are commonly associated with undesirable side effects and adverse drug interactions.

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