Wound Healing Composition Involving Mineral Ions and Methylglyoxal, and Methods of Use

a technology of methylglyoxal and mineral ions, applied in the field of wound healing compositions, can solve the problems of increasing antimicrobial resistance, increasing antimicrobial resistance, and increasing the annual death rate of ten million people, and achieve the effect of modulating biochemical mechanisms and reducing both wound protease activities and active infections

a technology of methylglyoxal and mineral ions, applied in the field of wound healing compositions, can solve the problems of increasing antimicrobial resistance, increasing antimicrobial resistance, and increasing the annual death rate of ten million people, and achieve the effect of modulating biochemical mechanisms and reducing both wound protease activities and active infections

US20170360982A1Inactive Publication Date: 2017-12-21PELOGENIX LLC
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  • Wound Healing Composition Involving Mineral Ions and Methylglyoxal, and Methods of Use

Examples

Experimental program
Comparison scheme
Effect test

embodiments

[0046]Embodiment 1 is a composition including a pharmaceutically-acceptable carrier, an effective amount of an active ingredient of inorganic solids including a magnesium salt, a potassium salt, a calcium salt, a zinc salt, a rubidium salt, a bromide salt, and a sulfate salt; and methylglyoxal as an antimicrobial at an amount between 500-2000 mg per kg, which is effective to reduce the number of viable microorganisms at a wound site, wherein each of the salts includes a pharmaceutically-acceptable counterion.

[0047]Embodiment 2 is the composition of embodiment 1, wherein the active ingredient of inorganic solids includes 1.5-75 parts of magnesium ions, 0.5-75 parts of potassium ions, 0.001-10 parts of calcium ions, 0.0001-10 parts of zinc ions, up to 5 parts of rubidium ions, 0.001-20 parts of bromide ions, and up to 20 parts of sulfate ions (said parts being expressed as parts by weight of the total weight of inorganic solids), and methylglyoxal representing 500-2000 mg per kg of th...

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Abstract

The invention provides compositions based on an effective amount of an active anti-inflammatory ingredient of mineral solids fortified with methylglyoxal antibacterial activity for the treatment of wounds; and methods of treating a wound, comprising contacting a wound with the above compositions or a wound dressing containing the above compositions.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This patent application is a divisional of and claims priority to currently pending U.S. Nonprovisional application Ser. No. 15 / 010,896, entitled โ€œWound Healing Compositions Involving Medicinal Honey, Metal Ions, and Methylglyoxal, and Methods of Use,โ€ filed Jan. 29, 2016, which claims the benefit under 35 U.S.C. ยง119(e) of U.S. Provisional Patent Application No. 62 / 109,369, entitled โ€œWound Healing Compositions Involving Medicinal Honey, Metal Ions, and Methylglyoxal, and Methods of Use,โ€ filed Jan. 29, 2015, the contents of each of which are hereby incorporated by reference into this disclosure.FIELD OF THE INVENTION[0002]The invention broadly relates to a wound healing composition, more specifically to a wound healing composition including various combinations of inorganic minerals, salts, methylglyoxal, and pharmaceutically acceptable carriers.BACKGROUND OF THE INVENTION[0003]Undesirable and dangerous side effects and adverse drug inte...

Claims

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Application Information

Patent Timeline
21 Dec 2017
Publication
US20170360982A1
IPC
A61L15/40; A61K31/121; A61K33/00; A61K33/04; A61K33/06; A61L15/46; A61K9/00; A61K35/644; A61K33/30; A61K47/10; A61L26/00
CPC
A61L2300/404; A61K33/06; A61L2300/216; A61L2300/102; A61K33/04; A61K33/30; A61K33/00; A61K35/644
Inventors
WARDELL, MARK RICHARD; SABACINSKI, KENNETH A.