12results about How to "Metabolic stability" patented technology

The invention provides a sulfoximine compound with an FGFR (Factor Growth Factor Receptor) inhibiting effect, a pharmaceutical composition containing the sulfoximine compound and application of the sulfoximine compound. The invention provides a sulfoximine compound which can be used as a fibroblast growth factor receptor (FGFR) inhibitor and is shown in a formula I, a tautomer, a stereoisomer, a hydrate, a solvate and pharmaceutically acceptable salt of the sulfoximine compound, a pharmaceutical composition containing the sulfoximine compound, and application of the sulfoximine compound in preparation of the pharmaceutical composition. Wherein R1, R2, R3, R4, R5, CyA, CyB, CyC and the like have the definitions given in the specification. # imgabs0 #

The invention belongs to the technical field of plant tissue culture, and particularly relates to a rapid tissue propagation method for radix ranunculi ternati. The rapid propagation method for the radix ranunculi ternati tissue comprises the following steps: (1) seed selection and disinfection: selecting vigorous seeds, cleaning the seeds, soaking the seeds with mercury bichloride, disinfecting the seeds with alcohol, and finally washing the seeds with sterile water; (2) preparing a primary induction culture medium: preparing the primary induction culture medium; (3) seed induction and proliferation: inoculating the disinfected seeds on a primary induction culture medium, and culturing; after 4-6 weeks of culture, the seeds germinate into plantlets; transferring the plantlets to a subculture induction medium for multiplication culture, and subculturing once every 3-4 weeks; (4) rooting culture: transferring the proliferation seedlings to a rooting culture medium, and culturing for 2-3 weeks until the adventitious buds can root to form complete plants; and (5) seedling hardening and transplanting. The method can improve the rooting rate and shorten the propagation time at the same time.

This invention provides a method for producing single-cell protein using a mixed bacterial culture, comprising the following steps: performing primary seed culture on methanogenic bacteria, *Tricholoma materata*, and *Glucosinolate methyl-eating bacteria* to obtain primary seed solutions; mixing the primary seed culture solutions evenly to obtain a mixed bacterial solution; inoculating the obtained mixed bacterial solution into a secondary seed culture medium for cultivation to obtain a secondary seed solution; inoculating the obtained secondary seed solution into a fermentation medium for scale-up cultivation to obtain a fermentation broth; separating the solid and liquid components of the obtained fermentation broth, harvesting the bacterial cells, and obtaining single-cell protein. This method for producing single-cell protein using a mixed bacterial culture improves the utilization rate of the carbon source methane and the yield of single-cell protein.

Compounds based on biaryl amides and coumarins having modified sugar groups for use in the treatment of diseases associated with heat shock protein pathways are provided. The compounds have the formula wherein the variables are as defined herein. Also provided are pharmaceutical compositions of the compounds of Formulae (I), (II), (III), (IV) and (V). These biaryl amide and coumarin-based derivatives with modified sugar groups are useful for the treatment and prevention of diseases and disorders, including neurological disorders such as neurodegenerative diseases and neurological injury disorders, such as diabetic peripheral neuropathy. # imgabs0 #

The application discloses a method for treating harmful substances in breeding waste. The method comprises the following steps: degrading vitamins by using a compost anaerobic fermentation method, separating heavy metals by using a composite chelating agent and an EKR-PRB device, killing pests in the manure pile by using a composite microbial agent, and finally adjusting the system environment by using a stabilizer, so that the treated manure pile is easy to be recycled.

The present application relates to the field of microbial technology, in particular to Citrobacter werkmanii and its application. The present application provides Citrobacter werkmanii SDT3 with dual functions of denitrification and cobalt (III) reduction under aerobic conditions, and the preservation number is CCTCC NO: M 2025956. The strain can efficiently realize aerobic denitrification reduction of nitrate and nitrite under aerobic conditions without additional ammonia nitrogen, and simultaneously complete the synchronous reduction of cobalt (III) -histidine complex (Co(III)His). The strain is suitable for treating flue gas denitration failure absorption liquid containing Co(III)His, nitrate and nitrite, has the advantages of high absorption liquid regeneration efficiency, mild process conditions, wide application range of organic carbon source, no secondary pollution, easy engineering application, etc.; can provide an efficient and stable microbial technology solution for efficient regeneration of flue gas denitration absorption liquid, long-term continuous and stable operation of the denitration system.

The invention relates to a method for increasing the seedling rate of seeds of extremely-small-population plants, i.e., hedyotis diffusa, and improving the growth state of seedlings. The method comprises the steps of collecting and screening the seeds, cleaning and sterilizing the seeds, promoting germination of the seeds, planting, transplanting and managing the seedlings. According to the method, the seedling rate of the seeds and the growth performance of the seedlings are remarkably improved, the seedling rate of normal seeds reaches 96.72%, the seedling rate of small seeds reaches 90.25%, the seedlings can grow to 45.52 cm in one year, the ground diameter can reach 5.04 mm, the seedlings are robust and consistent in growth state, and a seedling foundation, a scientific basis and a technical support can be provided for returning to nature and achieving population reconstruction; and a technical foundation is laid for the aspects of biological protection, ecological restoration, resource development and utilization and the like of the species, and the method has great practical significance for rescuing the endangered tree species.

The present application belongs to the technical field of chemical drugs, and relates to a compound shown in a general formula (I), or a racemate, or an isomer, or a pharmaceutically acceptable salt thereof, as a complement factor B inhibitor and a method for treating various specific diseases or conditions using the same.

The invention belongs to the technical field of medicines, and relates to an NLRP3 inflammasome inhibitor and application thereof. Specifically, the invention relates to a compound represented by a general formula (I), or a deuterated compound thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, and the definition of each group is as defined in the specification. Researches show that the compound represented by the general formula (I), or a deuterated compound thereof, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof has high biological activity on NLRP3 inflammasomes, and has important clinical development value Y-W-R3 (I) for treating NLRP3 related diseases.

The invention belongs to the technical field of chemical drugs, and relates to a compound as shown in a general formula (I), or a racemate thereof, or an isomer thereof, or a pharmaceutically acceptable salt thereof, # imgabs0 as a complement factor B inhibitor, and a method for treating various specific diseases or symptoms by using the complement factor B inhibitor.