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Traditional Chinese medicine composition with estrogen-like action and use thereof

A composition and estrogen technology, which can be used in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve problems such as restricting applications, increasing the prevalence of ovarian cancer, endometrial cancer, and other adverse reactions.

Inactive Publication Date: 2009-04-01
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the long-term single use of estrogen increases the prevalence of ovarian cancer, breast cancer, endometrial cancer and other adverse reactions, which limits its application

Method used

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  • Traditional Chinese medicine composition with estrogen-like action and use thereof
  • Traditional Chinese medicine composition with estrogen-like action and use thereof
  • Traditional Chinese medicine composition with estrogen-like action and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 (Eldocommia powder suspension, psoralen suspension, Eucommia psoralen suspension, Eucommia psoralen walnut kernel suspension, Eucommia psoralen garlic suspension, Eucommia psoralen walnut kernel The effect of garlic suspension on the uterus weight of immature mice)

[0020] 1.1 Experimental materials

[0021] 1.1.1 Test animals: KM mice, ♀, 21 days old, weighing 12-14 g (purchased from the Institute of Zoology, Chinese Academy of Sciences).

[0022] 1.1.2 Test drug and its preparation:

[0023] Eucommia powder suspension: 1.67g Eucommia pulverized through a 150-mesh sieve and mixed with 25ml of distilled water.

[0024] Psoralen suspension: 0.835g of psoralen is crushed through a 150-mesh sieve and mixed in 25ml of distilled water.

[0025] Eucommia psoraleae mixed solution: 1.67g of Eucommia ulmoides and 0.835g of psoraleae were crushed through a 150-mesh sieve and mixed with 25ml of distilled water.

[0026] Eucommia psoraleae and walnut kernel mixed sol...

Embodiment 2

[0037] Embodiment 2 (research on estrogen-like effect of Eucommia ulmoides, psoraleae, walnut kernel, garlic composition)

[0038] 2.1 Experimental materials

[0039] 2.1.1 Animals: KM species mice, ♀, 21 days old, purchased from the Institute of Zoology, Chinese Academy of Sciences, 60 healthy and mature KM species, ♀ mice (40±5 g) (provided by the Institute of Zoology, Chinese Academy of Sciences).

[0040] 2.1.1 Test drug and its preparation:

[0041] Pulverize Eucommia ulmoides, psoraleae and walnut kernels, steam dry garlic and beat powder through a 150-mesh sieve and mix them in a certain proportion to make a whole powder mixture (0.425g / kg, 0.85g / kg, 1.7g / kg, 3.4g / kg ); Nylestriol Tablets (Shanghai Pharmaceutical Group Hualian Pharmaceutical Factory).

[0042] Composition 0.425 g / kg of whole powder suspension: 6 parts of Eucommia, 3 parts of psoralen, 1.875 parts of walnut kernel, and 1.5 parts of garlic.

[0043] Composition 0.850 g / kg of whole powder suspension: 12...

Embodiment 3

[0093] Embodiment 3 (composition estrogen-like action antagonism experiment)

[0094] 3.1 Experimental materials

[0095] 3.1.1 Test animals: KM mice, ♀, 21 days old, weighing 12-14 g (purchased from the Institute of Zoology, Chinese Academy of Sciences).

[0096] 3.1.2 Tested drugs: diethylstilbestrol (purchased from Hualian Pharmaceutical Factory of Shanghai Pharmaceutical Group, approved by the Chinese Medicine: H3102164), the composition powder suspension (48 parts of Eucommia psoralen, 24 parts of walnut kernel, 15 parts of garlic, 12 parts).

[0097] 3.2 Experimental method

[0098] Select 11-13g of healthy female 21-day-old mice and divide them into 3 groups at random. They are given normal saline, nilestriol suspension group, and nilestriol+composition powder suspension group respectively, and each group is given daily Gastrointestinal administration (ig) at AM9:00, nilestriol+composition powder suspension group at 5:00 PM, continuous ig for 7 days, weighed 24 hours ...

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Abstract

The invention relates to a composition with the plant estrogen-like effects, and the composition is prepared by the following pharmaceutical raw materials by weight percentage: 12-64 percent eucommia bark and 6-38 percent malaytea scurfpea fruit. The traditional Chinese medicine composition has the plant estrogen-like effects and can bi-directionally regulate the estrogen level of human body, delay the arrival of menopause and be applicable to improving the perimenopausal syndrome of women: menstrual disorders, vasomotor symptoms (flushes and hot flushes), mental and neurological disorders (depression, anxiety, excitability and insomnia), cardiovascular and cerebrovascular symptoms (hypertension, hyperlipidemia, heart palpitations, atherosclerosis, coronary heart disease, senile dementia, and the like), bone and joint symptoms (osteoporosis, arthralgia, and the like), symptoms of urogenital tract and other diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition with estrogen-like effect. In addition, the present invention also relates to the application of the traditional Chinese medicine composition. Background technique [0002] With the increasing aging of the social population, the quality of life of the elderly has been widely valued by the society. The average life expectancy of women has increased year by year, which means that they will spend at least one-third of their time in perimenopause (menopause) Pass. Perimenopause refers to the period from the appearance of endocrine, biological and clinical features related to menopause to within one year of menopause. Syndrome of symptoms and signs of various organs caused by neuroendocrine, psychological and metabolic changes mainly caused by sex hormone reduction in perimenopause, main symptoms: menstrual disorders, vasomotor symptoms (flushing, hot flashes), mental and nervous disorder...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/46A61K36/52A61K36/8962A61P15/12
Inventor 王峥涛徐颖张紫佳吴弢苏式兵
Owner SHANGHAI UNIV OF T C M
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