128results about How to "Has anticancer activity" patented technology

The present invention relates to a harmine derivative compound and the application. The compound is produced through the structural modification of the 1st, 2nd, 3rd, 7th and 9th pint of the parent nuclear of the beta-carboline of the harmine; thus the novel harmine derivative compound is synthesized with the enhanced anti-tumor activity and no toxicity of the nervous system. Through the screening research of the vitro and vivo anti-tumor model, the harmine derivative compound is found to have the significant anti-tumor activity (the tumor-inhibition rate of the tumor-bearing mice model reaches as high as 63.5 percent), have no neurotoxicity, and have the prospects of clinical application. The preparation method of the compound is simple; the collection rate is high; and the compound is used for the drugs of treating various tumor diseases.

The invention relates to a group of glycosyl transferases and applications of the glycosyl transferases. Particularly, the invention provides applications of glycosyl transferases gGT25, gGT13, gGT30, gGT25-1, gGT25-3, gGT25-5, gGT29, gGT29-3, gGT29-4, gGT29-5, gGT29-6, gGT29-7, 3GT1, 3GT2, 3GT3 and 3GT4, and derived peptides of the glycosyl transferases in glycosylation catalysis and new saponin synthesis of terpenoids. The glycosyl transferases can specifically and efficiently catalyze hydroxyl glycosylation of C-20 bit and / or C-6 bit and / or C-3 of a tetracyclic triterpenoid compound substrate, and / or transfers the glycosyl groups from glycosyl donors to the first glycosyl groups of the C-3 bit and C-6 bit of the tetracyclic triterpenoid compound to extend a carbohydrate chain. The glycosyl transferases disclosed by the invention can also be applied to building synthetic rare ginsenosides and a plurality of novel ginsenosides and derivatives of the ginsenosides.

A beta-elemene five-element azacyclic derivative is disclosed, which is prepared through reaction of beta-elmene on hypochlorite or NBS to obtain intermediate, and reacting on 1,3,4-oxadiazole or 1,2,4-triazole thiol in DMF or DMSO solvent to obtain beta-elemene, 1,3,4-oxadiazole (or 1,2,4-triazole) derivative.

The invention discloses an antioxidant solid drink containing haematococcus pluvialis and blackcurrant powder. The antioxidant solid drink comprises the following components in parts by weight: 0.1-6.0 parts of haematococcus pluvialis, 3-10 parts of blackcurrant juice powder, 3-10 parts of cranberry juice powder, and 3-10 parts of blueberry juice powder. Through the synergistic effect and mutual promotion of antioxidant components, the antioxidant effect of the solid drink is improved, the cost of raw materials is greatly reduced, and meanwhile, the antioxidant solid drink has the functions of promoting appetite, maintaining normal activity of nerve, protecting visual function and the like.

The invention provides a medicated diet for improving functions of spleen and stomach and enhancing the immunoregulation capability and a preparation method of the medicated diet. The medicated diet comprises the following components: fructus jujubae, radix astragali preparata, ginseng, fried bighead atractylodes rhizome, poria cocos, fried semen coicis, agastache rugosus, radix paeoniae alba, fructus citrus sarcodactylis, fructus citri, Chinese yam, paederia scandens, caulis bambusae in taeniam, scorched medicated leaven, scorched malt, scorched hawthorn fruit, platycodon grandiflorum, radix aucklandiae, fructus aurantii, fructus amomi, pericarpium citri reticulatae, cassia twig, ginger, semen allii tuberose, radix saposhnikoviae, angelica sinensis, wolfberry fruit, rhizoma polygonati, lingzhi mushroom, rhodiola rosea, walnut meat, taraxacum, radix tinosporae, liquorice, brown granulated sugar and starch syrup. The medicated diet takes natural food materials, materials used as medicines and foods and materials used as health foods as the main raw materials, has the functions of invigorating spleen-stomach and replenishing qi, fortifying spleen and nourishing stomach, supporing Yang for consolidating superficies, reinforcing deficiency and strength, regulating qi function of human body, improving sub-health habitus and the like, can be used for improving functions of spleen and stomach and enhancing immunoregulation capability and has a good effect.

The invention relates to a zinc phthalocyanine complex and a preparation method thereof. The complex is (8-(7-coumarin oxygroup)-3,6-dioxoa-1-octyloxy; and the molecular formula of the zinc phthalocyanine complex is C42H32N8O6Zn. Coumarin oxygroup with a long alcoxyl chain is introduced at the periphery of the large ring of the zinc phthalocyanine, amphipathicity and biocompatibility of the zinc phthalocyanine complex are improved, and a photodynamic activity is improved. The zinc phthalocyanine complex is difficult to gather and favorable for improving cell intaking rate, and the photodynamic activity is improved; coumarin has an antitumor activity, and the coumarin is combined with photodynamic, so that the zinc phthalocyanine complex is favorable for serving as a photodynamic clinical medicine. The structure of a compound of the zinc phthalocyanine complex is single, and the compound is free from isomers, so that a product is easy to extract; and a synthetic method is simple, the side reaction is small, the yield is high, raw materials are readily available, cost is low, and industrial production is facilitated.

The invention relates to a synthesis method which comprises the steps of taking uridine as a principal raw material, treating with iodine and dilute nitric acid, obtaining 5-iodine uridine, treating with acetic anhydride to form 2',3',5'-O-trioxide acetyl-5-iodine uridine, allowing 2',3',5'-O-trioxide acetyl-5-iodine uridine to react with 2-(tributyl stannane) furan or thiophene by the action of triphenyl phosphine palladium chloride to form an intermediate, deprotecting by stirring in an ammonia methanol saturated solution at the room temperature by the action of phosphorus pentasulfide, and obtaining 5-(2-furyl or thienyl)-4-sulfur-bearing uridine. The compound has absorption at 363nm, and higher sensitivity to ultraviolet A, can enter inner cells of a tissue and act on cancer cells selectively, and overcomes the disadvantages that a photosensitive reagent for optic treatment at present is not gathered in nuclei and cannot selectively act on the cancer cells. The compound belongs to a novel base sulfur-bearing nucleoside compound, absorption light waves of the compound are in a long wavelength region, and the compound can selectively act on the inner cancer cells of the tissue, has a potential pharmaceutical value, and enters the inner cells of the tissue easily.

The invention discloses 5-iodine-4-sulfur-2'-deoxyuridine, and derivatives and a synthetic method of the 5-iodine-4-sulfur-2'-deoxyuridine. The synthetic method comprises the steps of using 5-iodine-2'-deoxyuridine as main raw material, treating by using acetic anhydride under a certain conditions to obtain 3', 5'-O-dioxo acetyl-5-iodine-2'-deoxyuridine, reacting under the action of phosphorus pentasulfide, then, introducing ammonia to saturated methanol solution, stirring and deprotecting at the room temperature to obtain 5-iodine-4-sulfur-2'-deoxyuridine. According to the invention, the compound and the derivatives have greatest absorption with the ultraviolet spectrum at 345 nm and stronger UVA photosensitivity. Therefore, the compound provided by the invention is a new basic base sulfur-containing nucleosides compound, can alternatively acts on cancer cells and has potential medical value; besides, the synthetic method provided by the invention has the advantages of simple reaction conditions, accessible raw material, low cost, high product yield, high purity and high efficiency.

The invention discloses a synthetic method of an alpha, beta-diamino acid derivative. In the method, a one-step reaction is undergone by taking a diazo compound, aniline and aldehyde acid ester as raw materials, taking metal Lewis acid and chiral phosphoric acid as catalysts, taking an organic solvent as a solvent and taking a 4 Angtrom molecular sieve as a water absorbing agent, so that the alpha, beta-diamino acid derivative is obtained. The synthetic method disclosed by the invention has the advantages of high atom economy, high selectivity and high yield, the reaction conditions are mild, and operation is easy and safe. The alpha, beta-diamino acid derivative has anticancer activity and structural diversity, and is suitable for preparing and applying antitumor, antibiotic and antifungal medicaments.

The invention discloses a chemical substance with anticancer activity and a preparation method and application thereof, belongs to the technical field of chemically-synthesized medicine, and aims to provide the chemical substance with low cytotoxicity, low drug resistance and high anticancer activity. The chemical substance is a compound as shown in formula (I), a compound as shown in formula (II) or the mixture of the compound as shown in formula (I) and the compound as shown in formula (II). The chemical substance has the advantages that the chemical substance is obtained by the mating reaction of artesunate and a platinum (IV) compound, the cytotoxicity of the platinum (IV) compound is lowered by introducing the artesunate ligand, the anticancer cavity of the platinum (IV) compound is increased, and the chemical substance is low in drug resistance and widely applicable to the preparation of anticancer medicine.

The invention relates to synthesis of a laminine Schiff base mononuclear complex with anticancer activity, and a pharmaceutical composition thereof. The synthesis method concretely comprises: (1) synthesizing a condensed laminine 2-pyridylaldehyde Schiff base mononuclear complex; (2) synthesizing a laminine phenanthroline copper mononuclear complex; (3) synthesizing a condensed laminine 2-pyridylaldehyde Schiff base phenanthroline copper mononuclear complex; (4) synthesizing a condensed bis-laminine 2-pyridylaldehyde Schiff base copper mononuclear complex; and (5) synthesizing a condensed laminine 2-pyridylaldehyde Schiff base platinum mononuclear complex. By carrying out pharmaceutical analysis research aiming at the compound, the invention provides a synthesis method of the laminine Schiff base mononuclear complex with anticancer activity, and a synthesis method of a pharmaceutical composition thereof, the pharmacological analysis is carried out to prove that the compound has an anticancer active effect, is suitable for use in the anticancer field, and has larger medical and medical values.

A method for preparing deoxyfructosazine through chitin biomass comprises the following steps: uniformly mixing a dry chitin biomass raw material, an imidazole ionic liquid solution and an additive in a dimethyl sulfoxide reaction medium for reaction to obtain an intermediate product; adding a crystal solvent in the intermediate product to completely dissolve the product, performing hot filtration to remove insoluble impurities, performing rotary evaporation concentration on a filtrate, and performing recrystallization to obtain the product, namely the deoxyfructosazine. The method has the advantages that the raw material source is wide, pollution is avoided, the preparation is simple, and the product purity is high.

The invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to bis(2-acetylpyrazine) thiocarbonohydrazone and a preparation method of a bismuth (III) complex thereof and the application of the bismuth (III) complex in preparation of anti-cancer drugs. The molecular formula of the complex is [Bi(HL)(NO3)2(H2O)], wherein 2L represents to bis(2-acetylpyrazine) thiocarbonohydrazone. The molecular formula of the bis(2-acetylpyrazine) thiocarbonohydrazone consists of one hexadentate ligand bismuth ion, two monodentate nitrate ions, one ligand water molecule and one single deprotonated N2S tridentate ligand (2-acetylpyrazine) thiocarbonohydrazone. The complex has an obvious function of inhibiting the growth of human colorectal cancer cells HCT-116 and human liver cancer cells HepG2; and the research result provided by the invention provides an experimental basis for the bismuth metal complex in medicament.

The invention discloses a phellinus igniarius flavored beverage and a preparation method thereof. The flavored beverage is mainly composed of the following components in parts by weight: 90-110 parts of a phellinus igniarius filtrate concentrated solution, 3-10 parts of soybean oligosaccharide, 5-8 parts of high fructose corn syrup, 1-3 parts of honey, 0.08-0.12 part of L-malic acid, 0.004-0.006 part of potassium sorbate and 0.06-0.1 part of xanthan gum. The phellinus igniarius flavored beverage disclosed by the invention is rich in active ingredients in phellinus igniarius, has coordinated sweet and sour tastes, suitable viscosity and good stability, and is suitable for a large range of people to eat; and the phellinus igniarius flavored beverage is simple to prepare, has a unique flavor, is convenient to eat, and is a flavored health beverage suitable for people of all ages.

The invention discloses a preparation method of a pleiotropic fullerene-vitamins-water-soluble macromolecular ternary complex. The preparation method comprises the following steps of: forcibly mixing fullerene powder, vitamins and water-soluble molecules; then adequately stirring the mixed material in water; and filtering to obtain a transparent filtrate and evaporating to obtain a water-soluble fullerene / vitamine complex. Based on an antioxidant and antibacterial fullerene-water-soluble macromolecular system already invented, vitamins with antioxidation and anti-cancer activity are further introduced to the fullerene-water-soluble macromolecular system so as to obtain a multifunctional water-soluble complex system with antioxidation, antibacterial property and anti-cancer characteristic. The complex has wide application prospect in the fields of cosmetic, biomedicine and the like.

The invention discloses a preparation method of colorful crisp potato chips through osmotic dehydration and vacuum freeze-drying. According to the preparation method, an osmotic dehydration technology and a vacuum freeze-drying technology are combined, a sucrose solution is firstly taken as an osmotic solution to remove part of moisture in the colorful potato chips, and then the colorful crisp potato chips are prepared with the vacuum freeze-drying technology. According to the scheme, the drying temperature is low, the drying time is shorter than that of single vacuum freeze-drying, the prepared colorful crisp potato chips have good color, luster and shape and taste crisp and slightly sweet, and nutrient substances of the prepared colorful crisp potato chips are almost not lost; besides, with the adoption of the method, anthocyanin in the colorful potato chips can be reserved to the greatest extent, so that the prepared colorful crisp potato chips have certain functions of resisting to oxidation, eliminating free radicals and delaying senescence; further, the colorful crisp potato chips have functions of protecting the liver and preventing cardiovascular diseases as well as certain anti-mutation effect, antitumor activity and antiviral activity.

The invention relates to a halogen-substituted isoindoline compound as shown in the following formula I and application of the halogen-substituted isoindoline compound. The compound provided by the invention has obviously more excellent anti-tumor activity, and can be prepared into an oral dosage form which is more convenient, safer and more economical for administration. Therefore, the utilization value is remarkably improved compared with that of the existing compound.

The invention discloses a method for preparing a nitrogen-containing heterocyclic ring compound by use of chitin biomass. The method comprises the following steps: uniformly mixing a chitin biomass raw material, an imidazole type ionic liquid solution and an additive for reaction, sequentially adding acetic oxide and pyridine into a reaction product for acylation, quenching the acylation-finished reaction liquid, adding an extracting agent into the acylation-finished reaction liquid for extraction, rotationally evaporating and concentrating to obtain an acylation product, adding an NaOH solution into the acylation product which is obtained through the extraction, stirring under a water-bath condition, adding hydrochloric acid which has the same molar weight as alkali, adding methanol, filtering to remove inorganic salt, rotationally evaporating and concentrating the filtrate to obtain a deacylation product, and crystallizing the deacylation product. The method disclosed by the invention has the advantages of simple process, high product purity, high yield and short reaction time.

The invention relates to healthcare beverage and a preparation method thereof. The healthcare beverage has functions on assisting the adjustment of blood fat and blood pressure. Salvia miltiorrhiza bge.f.alba and hawthorn are adopted as raw materials, and the beverage comprises the following compositions by weight ratio: 10 parts of salvia miltiorrhiza bge.f.alba, 5 parts of hawthorn, 1 part of crystal sugar, 1 part of honey, 100 parts of purified water and 0.02 percent of p-hydroxybenzoate (g.ml<-1>). The healthcare beverage has simple formula, is convenient to take, has a remarkable effect, and is suitable for the flavor of a particular group of people and satisfies the requirement on adjusting the function of the human body.

The invention discloses preparation methods of 3-amino-3-hydroxymethyl oxoindole and a 3-hydroxyl-3-hydroxymethyl oxoindole derivative; with 3-diazonium oxoindole, aniline and formaldehyde or 3-diazonium oxoindole, water and formaldehyde as raw materials, with rhodium acetate as a catalyst and an organic solvent as a solvent, and through a one-step reaction, the product 3-amino-3-hydroxymethyl oxoindole and the 3-hydroxyl-3-hydroxymethyl oxoindole derivative are obtained. The preparation methods have the advantages of high-efficiency atomic economy, high selectivity and the like, and the operation is simple, safe and reliable. The 3-amino-3-hydroxymethyl oxoindole and the 3-hydroxyl-3-hydroxymethyl oxoindole derivative have anti-cancer activity and contain important natural product and active pharmaceutical molecular intermediate skeletons, and have broad application prospects in the field of medicine and chemical industry.

The invention discloses cation amphiphilic membrane targeted alpha-helix polypeptides and an application thereof. The polypeptides comprise an amino acid sequence [X1X2X3X1X2X3X1]n-NH2, wherein NH2 represents amination of C terminal; X1 is polar amino acid with positive charges; X2 and X3 are nonpolar hydrophobic amino acids; n is a positive integer; and all amino acids are L type amino acids. According to the invention, a series of cation amphiphilic membrane targeted alpha-helix polypeptides are provided, and have anti-cancer activity; different types of hydrophobic amino acids (L, I, F, A and the like) are remarkably different in the membrane action effect; and if the concentration is higher than the key micelle forming concentration, the hydrophobic amino acids can be self-assembled into a micro-micelle to generate a violent cell killing effect, and a new basis is provided for the development of anti-cancer drugs.

The invention discloses a 3-amino-3-hydroxymethyloxindole derivative shown as a formula (I) and a preparation method thereof. The 3-amino-3-hydroxymethyloxindole derivative is obtained by taking 3-diazooxindole, aniline and formaldehyde as raw materials, taking rhodium acetate as a catalyst and taking an organic solvent as a solvent through a one-step reaction. The preparation method disclosed by the invention can be used for constructing a compound with a plurality of functional groups in one step, and has the characteristics of high flexibility, high selectivity, efficient atom economy, high yield and simplicity and safety in operation and the like. The invention further discloses an inhibition effect of the 3-amino-3-hydroxymethyloxindole derivative shown as the formula (I) on proliferation of five types of tumor cells including human osteosarcoma cells (SJSA-1), human colorectal cancer cells (HCT-116), hepatocellular carcinoma cells (BEL7402), human oral epidermoid carcinoma cells (KB) and human T-cell leukemia cells (Jurkat).

The invention provides a novel wool gonane compound as well as a preparation method and an anticancer purpose thereof. The wool gonane compound is shown as the right general formula (I); and an anticancer activity test indicates that the novel wool gonane compound has obvious anticancer activity, wherein R1 and R2 in the formula are respectively and independently selected from hydrogen and alkyl with 1-6 of carbon number.

The invention relates to a lucid ganoderma and America ginseng capsule, and belongs to the technical field of health product. The provided capsule is composed of a capsule shell and contents encapsulated in the capsule shell, wherein the contents are composed of the following raw materials in percentage by weight: 30 to 65% of lucid ganoderma extract, 20 to 50% of American ginseng extract, 10 to 30% of microcrystalline cellulose, and 0.5 to 2.5% of magnesium stearate. The capsule has the advantages of scientific formula and no side or toxic effect, and has the functions of relieving fatigue, preventing aging, boosting qi, tranquilizing, refreshing the spirit, improving memory, regulating internal secretion, strengthening human immunity, and improving the cardiovascular state.

The invention discloses a bacterium AD05 which is separated from a human intestinal tract and can generate anti-cancer active metabolites and application of the bacterium AD05. Feces of healthy persons is used as a sample and is screened by the aid of first Gauserime solid culture media with potassium dichromate, so that the bacterium which can generate the anti-cancer active metabolites can be ultimately separated from the human intestinal tract and is named as AD05. The bacterium AD05 and the application have the advantages that the bacterium AD05 has the closest genetic relationship with Fimbriimonas ginsengisoli Gsoil 348 as discovered in 16S rRNA (ribosomal ribonucleic acid) comparison, and obvious anti-tumor activity of the bacterium AD05 and the metabolites of the bacterium AD05 is sufficiently proved by experiments; the bacterium is sourced from the human intestinal tract and accordingly has little or zero side effects for human bodies; a novel technical means is provided for tumor therapy, and important effects can be realized for development of biological tumor therapy.

The invention discloses application of physalis pubescens lactone B in preparing anti-cancer drugs. The physalis pubescens lactone B is a compound having a structure as shown in formula I; the physalis pubescens lactone B is combined with cis-platinum in use to prepare anti-cancer drugs; the compound having the structure as shown in the formula I serves as a novel STAT3 inhibitor, and simultaneously acts as a chemotherapy synergist which, combined with the cis-platinum, can take a synergistic action to greatly improve an anti-cancer activity. Test results show that the physalis pubescens lactone B, as a novel STAT3 inhibitor, has an anti-cancer activity and can be used for preparing anti-cancer drugs. When combining the physalis pubescens lactone B and the cis-platinum in use, a strong synergistic action is generated; compared to single use of the cis-platinum, the combination of the physalis pubescens lactone B and the cis-platinum shows stronger anti-cancer activity; the anti-cancer drugs prepared by the combination of the physalis pubescens lactone B and the cis-platinum are favorable for market promotion and have wide application prospect. The formula I is as shown in the specification.

The present invention relates to N1, N8-disubstitutent-triethyl tetramine copper (II) complex as one kind of small molecular polyamine metal complex. Research shows that N1, N8-disubstitutent-triethyl tetramine copper (II) complex may be combined with DNA at the major groove in the insertion mode, the DFT process confirms the action mode between the complex and DNA, gel electrophoresis process shows that the complex can incise DNA, and MTT process proves the cancer cell inhibiting effect of the complex, so that the complex may be used in developing effective chemical nuclease and high efficiency and low toxicity anticancer medicine.

The present invention relates to a recombinant plasma membrane-based vesicle, and more specifically to a recombinant plasma membrane-based vesicle comprising a VSV-G mutated protein in which histidine, which is the 162nd amino acid in the membrane, has been replaced with arginine, and a pharmaceutical composition, for treating cancer, comprising the recombinant plasma membrane-based vesicle.

The invention relates to dama-20S, 25S-epoxy-3beta, 12beta, 26-triol, as well as an extracting method and a pharmaceutical application thereof and belongs to the field of medicines. The extracting method comprises the following steps: getting proper amount of the American ginseng stem, adding 3-8 times of 60-95% ethanol, heating, performing reflux extraction, extracting 50L for 3-6 hours each time and for 5-7 times, combining the extracting solution, and recovering the solvent till the solvent does not exist; performing silica gel column chromatogram on the ethanol extractive with an eluent comprising CHCl3 and MeOH at a ratio of 90-120:10-30, performing C18 reversed-phase column chromatography with an eluent comprising MeOH and H2O at a ratio of 80-90:20-10, and recrystalizing with ethanol and water in the ratio of 2:4-6 to obtain the Dama-20S, 25S-epoxy-3beta, 12beta, 26-triol. The compound not only has an antitumor activity, but also has the pharmacological actions for treating the coronary heart disease, the myocardial ischemia, the ischemia shock, the arrhythmia and the reperfusion injury, and can be used for preparing the medicines for treating the coronary heart disease, the myocardial ischemia, the ischemia shock, the arrhythmia and the reperfusion injury and the medicines for resisting liver cancer, mammary cancer, cervical carcinoma and astroglioma; besides, the compound has the characteristics of wide action scope and obvious effect.

The invention discloses a preparation method and application of a novel ferrocene derivative containing free radicals of nitroxide. The ferrocene derivative containing free radicals of nitroxide, pharmaceutically acceptable salt or a pharmaceutically acceptable solvate of the ferrocene derivative, or a pharmaceutical composition is shown in formula (I). The novel ferrocene derivative shown in the formula (I) has very high inhibitory activity on a lung cancer cell line A549 and a breast cancer cell line MCF-7, and can be used as a candidate compound or a lead compound for treatment of cancer, tumor and other diseases.