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Novel wool gonane compound as well as preparation method and anticancer purpose thereof

A compound, alkyl technology, applied in the field of anticancer compounds, can solve problems such as no anticancer activity, reports, etc.

Inactive Publication Date: 2009-12-23
李贺然
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there have been studies on the black tiger, there are no reports on its anticancer activity

Method used

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  • Novel wool gonane compound as well as preparation method and anticancer purpose thereof
  • Novel wool gonane compound as well as preparation method and anticancer purpose thereof
  • Novel wool gonane compound as well as preparation method and anticancer purpose thereof

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] 1. The preparation of the compound of general formula (I).

[0018] The roots and rhizomes of black tiger are collected from Guangxi. After pulverizing 1.75Kg of the above-mentioned black tiger root, extract by cold immersion in 80% acetone for 3 times, each time for 24 hours, combine the extracts, and concentrate the extracted extract obtained with cyclohexane, chloroform, ethyl acetate, n-butanol successively extraction. The chloroform layer part was subjected to repeated column chromatography on a silica gel column, and the solvent system was chloroform-methanol (100:0-0:100) to obtain the following compounds 1-3.

[0019]

[0020] Compound 1 R1=R2=H

[0021] Compound 2 R1=CH3, R2=H

[0022] Compound 3 R1=R2=CH3

[0023] The NMR data of the above compounds are as follows.

[0024] Table-1 13 C-NMR (150MHz) Data of 1, 2 and 3 (CDCl 3 )

[0025]

[0026] 2. Anticancer activity of the above compounds 1-3

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Abstract

The invention provides a novel wool gonane compound as well as a preparation method and an anticancer purpose thereof. The wool gonane compound is shown as the right general formula (I); and an anticancer activity test indicates that the novel wool gonane compound has obvious anticancer activity, wherein R1 and R2 in the formula are respectively and independently selected from hydrogen and alkyl with 1-6 of carbon number.

Description

technical field [0001] The invention relates to a novel anticancer compound, its preparation method and its anticancer application, in particular to a lanosterane compound, its preparation method and its anticancer application. Background technique [0002] At present, tumor is still a disease that threatens human life. According to the statistics of the World Health Organization, the number of cancer deaths in the world reached 1 million in 1993, accounting for 12% of the global death toll, and developing countries accounted for the majority (about 58%). The number of deaths from cancer in the world's industrial countries is estimated to be about 250,000, accounting for about 25% of the deaths. People urgently need to find different types of lead compounds or anticancer drugs with high anticancer activity through various ways. [0003] Black Tiger is the root and cane of Kadsura coccinea (Lem.) AC. The root bark of the cold rice ball is dry, slightly rough on the outside,...

Claims

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Application Information

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IPC IPC(8): C07C57/26C07C69/608A61K31/194A61K31/225A61K36/57A61P35/00A61K31/56C07J9/00
Inventor 李贺然
Owner 李贺然
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