33 results about "Sterane" patented technology

The invention relates to the technical field of oil gas geochemistry, in particular to a quantitative analysis method for judging petroleum degradation grade. The quantitative analysis method comprises the following steps: a sample preparation step of dehydrating a water-containing degraded oil sample and then weighing 50-100mg of the dehydrated water-containing degraded oil sample in a sample bottle; a sample degradation grade quantitative analysis step of analyzing the sample by using comprehensive two-dimensional gas chromatography-time of flight mass spectrometry; calculating the relativemass of n-isoparaffin, cyclane, arene and sterane, and terpane compound according to a peak area of a comprehensive two-dimensional gas chromatogram to be respectively denoted as A, B, C, D, and calculating an X value, wherein X=A / (A+B+C+D), the smaller the X value is, the larger the degradation grade is. The quantitative analysis method of the invention can finely divide the crude oil with the same source and the same degradation grade, thereby classifying the crude oil for geological research.

An optimal preparation and analytic method for the extraction of Antrodia cinnamomea is disclosed. The important parameters for the extraction efficiency of the extract are analyzed using mathematic and statistical experimental designs, and the extract of A. cinnamomea and its particular triterpenoid compounds are quantified and identified using the quantitative NMR and HPLC-tandem MS. Whether the ergostane and lanostane triterpenoid compounds are contained in one drug, health food or other products and the total amounts and individual amounts therein can be analyzed, determined or quantified using the techniques disclosed herein.

The present invention relates to a method for analyzing sterane-based compounds in a petroleum geological sample. According to the method, organic matters in a rock core sample are extracted with an organic solvent, and the extracted supernatant is directly analyzed through atmospheric pressure photoionization high resolution mass spectrometry (APPI FT-ICR MS). According to the present invention,with the method, the sample consumption is low, the sample preparation process is simple, the sample extraction time is short, and the extract can be directly subjected to atmospheric pressure photoionization high resolution mass spectrometry analysis without concentration and separation so as to avoid the compound loss caused during the separation; and the atmospheric pressure photoionization high resolution mass spectrometry analysis process is accurate and rapid, the sterane-based compound carbon number distribution range detected by the high resolution mass spectrometry has high reliability and high accuracy compared to the GC-MS results, and the method for analyzing the sterane-based compounds in the petroleum geological sample is expanded.

The invention discloses a chalcone derivative containing an allyl structure and its application. The invention synthesizes 39 new allyl-post-steranes based on Licochalcone A and E as promolecules. As a PTP1B inhibitor, it may improve the common treatment of type 2 diabetes. Most of the synthetic compounds showed potent inhibition of PTP1B.

A crude oil density prediction method based on saturated hydrocarbon biomarker parameters, comprising: collecting crude oil saturated hydrocarbon biomarkers, including n-alkanes series, terpanes series, sterane series and alkylcyclohexane series biomarkers identification and Relative quantification; calculate crude oil saturated hydrocarbon parameters; establish a fitting formula based on the correlation between crude oil saturated hydrocarbon parameters and surface crude oil density; predict the surface crude oil density of the target oil-bearing formation according to the fitting formula. The purpose of the present invention is to predict the surface crude oil density of the target oil-bearing layer system by gas chromatography-mass spectrometry analysis of the saturated hydrocarbon components of the wall core or a small amount of rock core extract. The invention performs fitting and forecasting of medium and light oil and heavy oil in sections, and has the advantages of simple operation, low cost, high precision and few affected factors.

The invention relates to a molecular sieve separating and preparing method for sterane and diahopane. 60mg of crude oil or rock extracts are prepared, 6g of solica, the particle diameter of which is 40 micrometers, is used for filling columns, and 15ml of n-hexane is used for preparing saturated hydrocarbon in a leaching manner; ZSM molecular sieve with the weight about 100 times the weight of the saturated hydrocarbon is used for filling columns and 20ml of isooctane is used for preparing cyclic hydrocarbon in the leaching manner; 10X molecular sieve with the weight about 300 times the weight of the cyclic hydrocarbon is used for filling columns, and after 30 minutes, 80ml of n-pentane is used for preparing fractions; the solvent of fractions is recovered and volatilized, the fractions are then weighted, 10X molecular sieve with the weight about 200 times the weight of the fractions is used for filling columns and after 30 minutes 10ml is used for preparing sterane in the leaching manner; the filling materials in the third step is dried by the nitrogen, which are then extracted by the isooctane for 12 hours to get diahopane. The separation effect is good after the mass detection of a chromatograph, which is similar to the effect of the separation spectrogram exhibited in foreign countries and the operation of the enriching and separating method of diahopane is simple.

The invention provides a comprehensive two-dimensional gas chromatography quantitative analysis method of an aromatic sterane compound in petroleum. The method comprises the following steps: fully dissolving and soaking crude oil with a solvent and then filtering to obtain a filtrate; heating to evaporate and concentrate the filtrate to prepare filtrate concentrate; collecting a saturated hydrocarbon group component and an aromatic group component; preparing a saturated hydrocarbon group component sample and an aromatic group component sample and storing the samples at low temperature; analyzing the two samples by using a comprehensive two-dimensional gas chromatograph and a flight time mass detector; performing data processing on spectrograms obtained in the steps to obtain corresponding retention time and peak area integration result. The analysis method can be used for performing full oil analysis and group component analysis; an orthogonal separation system thereof can completely separate the aromatic steroid hydrocarbons from alkane, so that the problems such as common rolling peak, base line interference and insufficient peak capacity can be excellently solved, and the aromatic sterane compound can be accurately measured.

The invention discloses a method for efficient separation and recycling of 5,10-alpha epoxy isomer in telapristone synthesis. A 5,10-alpha epoxide is a key intermediate in a telapristone synthesis process, and preparation of a high-purity 5,10-alpha epoxy isomer is the key in control of a whole quality system. The 5,10-alpha isomer is efficiently separated by means of solvent pulping for the first time, the content reaches 99%, and the yield is up to 65%. More significantly, a mixture of two epoxy isomers in mother solution after separation of the 5,10-alpha epoxy isomer can be subjected to reduction and elimination reaction to return to a raw material 17beta-cyano-17alpha-trimethylsiloxy-13beta-methyl sterane-5,9-diene-3,3-(ethylenedioxy). The method is remarkable in improvement of raw material utilization efficiency and has a large-scale application prospect.

The invention discloses an androstane-3β-hydroxy-17-ketone-6α-boronic acid obtained by separating androstane-3β-hydroxy-17-ketone-6α-boronic acid from a chemical reduction reaction solid waste of androst-5-ene-17-ketone through esterification, oxidation and sulfonic acid. A method for preparing 3β-acetoxyandrost-5-ene-17-ketone by esterification and elimination four-step reaction. The method of the invention can effectively recycle and reuse the steroid solid waste, the synthesis method is efficient, the reaction conditions are mild, the environmental pollution is reduced, and the cost of related products is correspondingly reduced.

The present invention relates to the new process of synthesizing furasteroid saponin and its derivative chemically with C27 helical sterane type sapogenin and various kinds of saccharide as material. The synthesis process includes the following steps: 1. synthesizing completely protected C27 helical steroid saponin through the reaction of C27 helical sterane type sapogenin and acyl radical, alkyl radical or silicon radical protected glycosyl donor; 2. reaction of completely protected helical steroid saponin and oxidant to obtain oxidized product; 3. reaction of oxidized helical steroid saponin and oxyphilic reagent to produce place 26 halogenated saponin derivative; 4. nucleophilic substitution reaction of nucleophilic reagent and the halogenated product to introduce XR3 radical; 5. reducing the place 16 carbonyl radical in saponin selectively with reductant; and 6. eliminating all the protecting radicals to obtain furasteroid saponin and its analog.

The invention discloses an application of Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxy in preparation of medicaments for preventing and / or treating enterovirus 71 infection. The invention confirms that the Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxy has good antiviral effect in in-vitro enterovirus 71 (EV 71) infection cell tests. Meanwhile, the Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxyhas certain killing effect on enterovirus 71 (EV 71), can prevent enterovirus 71 (EV 71) infection, has good treating effect on enterovirus 71 (EV 71) infected cells, has good inhibition effect on viral replication, and has more significant effect than a positive control medicament of ribavirin. In addition, the Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxy has good inhibition effect on inflammation responses caused by enterovirus 71 (EV 71), which reveals that the Lanosta-7,9(11),24-trien-3-one 15,26-dihydroxy has the prospect of being developed into anti-enterovirus 71 (EV 71) medicaments.