26 results about "Oxidative cleavage" patented technology

The invention discloses a method for directionally preparing high-purity azelaic acid from oleic acid based on a micro-channel reactor, which comprises the following steps: mixing oleic acid and hydrogen peroxide dissolved with a catalyst, and feeding the mixture into the micro-channel reactor for oxidative cracking reaction to obtain oxidation liquid mainly containing the azelaic acid and the oleic acid; standing and layering the oxidation liquid to obtain a water phase A and an oil phase A; hot water is introduced into the oil phase A containing the nonanoic acid and the azelaic acid for extraction and liquid separation, and a water phase B and an oil phase B are obtained; fractionating the oil phase B to obtain high-purity nonanoic acid; cooling and crystallizing the water phase B to obtain a crude azelaic acid product, and melting and evaporating the crude product to remove moisture to obtain high-purity azelaic acid. Based on the microchannel reactor, hydrogen peroxide is used as an oxidizing agent, oleic acid double bonds can be directionally oxidized through a catalyst system, oleic acid is directly oxidized and cracked into nonanoic acid and azelaic acid in a short time, the reaction efficiency can be greatly improved, the reaction time can be shortened, and the use of a solvent and a phase transfer catalyst is avoided; the method has the advantages of high selectivity, high safety and remarkable environmental protection.

Disclosed in the present invention is a method for directly preparing a phenol and an aldehyde or a ketone from an alkyl aromatic hydrocarbon as a raw material on the basis of a selective carbon-carbon bond oxidative cleavage reaction. The method is carried out on the basis of the following steps: mixing an alkyl aromatic hydrocarbon as represented by general formula (I) with a photocatalyst, hydrobromic acid, and an organic solvent and enabling the mixture to react under the conditions of oxygen as an oxidant and light irradiation to simultaneously prepare a phenol compound as represented by general formula (II) and a ketone or aldehyde compound as represented by general formula (III). In the present invention, bulk alkyl aromatic hydrocarbons are used as raw materials for reaction to produce phenol, aldehyde, and ketone organic chemical raw materials. Compared with traditional synthesis methods, the present invention has many advantages such as inexpensive and readily available catalysts, mild reaction conditions, simple operation, good selectivity, and high safety, is suitable for large-scale synthesis of phenols, p-cresol, cyclohexanone, etc., and exhibits wide application prospects.

The method comprises the following steps: taking androstane-3-ketone-4-ene-17beta-carboxylic acid shown in a formula II as a raw material, carrying out decarboxylation hydroxylation, sulfonylation, elimination and double-bond oxidative cracking to prepare the exemestane intermediate shown in a formula VI, and then sequentially carrying out allylic oxidation, wittig reaction and 1, 2, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3-trimethyl-1, 3, 4-trimethyl-1, 3 the exemestane shown in the formula I is prepared through the step of 1, 2-site dehydrogenation. The method has the characteristics of simple process operation, mild conditions, high reaction yield and the like, and is suitable for industrial production.

The invention discloses high-oleic-acid sunflower seed oil and a preparation method thereof, and belongs to the technical field of deep processing and refining of vegetable fat. According to the method, polyunsaturated fatty acid in triglyceride is preferentially converted into low-boiling-point fatty acid alkyl ester through selective enzymatic alcoholysis / ester exchange reaction, volatility difference is constructed, and directional enrichment of oleic acid components and segmented removal of low-boiling-point impurities are achieved through multi-stage short-path molecular distillation. According to the method, the content of oleic acid in the sunflower seed oil can be increased from 60-75% to 80-90%, the content of linoleic acid can be reduced from 15-30% to 5-12%, meanwhile, free fatty acid, peculiar smell precursors and oxylysate are effectively removed, the oxidation stability of the product is excellent, and the retention rate of nutritional ingredients is high. The linoleate-rich fraction generated in the technical process can be used as a high-added-value byproduct, so that the synergistic value increase of the main and by-products is realized.

The application discloses a method for preparing carboxylic acid ester compounds by oxidizing and breaking carbon-carbon double bonds of olefin compounds. The method comprises the following steps: adding olefin compounds, an additive and a nitrogen-doped mesoporous carbon loaded cobalt-based catalyst into a primary aliphatic alcohol solvent, placing the mixture into a pressure container, and introducing an oxygen source gas with a pressure of 0.5-0.9 MPa at a reaction temperature of 80-150 DEG C. The product after the reaction is a carboxylic acid ester compound. The method has a wide application range, the reaction conditions are easy to control, the catalyst can be recycled, the post-treatment is simple, and the method is suitable for industrial production.

The invention relates to a method for the selective electro-oxidative fragmentation of lignin using an electrochemical system, comprising the following steps: (i) synthesis of a nickel-cobalt electrocatalyst; (ii) obtaining an anode coated with the electrocatalyst; and (iii) selective fragmentation and oxidation of solubilised lignin in an electrochemical reactor comprising said anode, in which vanillic acid and syringic acid are obtained as preferred products.

This invention discloses an oleic acid oxidative cracking catalyst, its preparation method, and its application, belonging to the field of catalyst preparation technology. The catalyst for the oxidative cracking of oleic acid to azelaic acid is prepared by: uniformly mixing phosphotungstic acid with an organic onium salt, and then ball milling the mixture in a ball mill jar. The preparation method is simple, generates no waste, and produces a catalyst with high yield and high activity. In the process of oleic acid cracking to azelaic acid, the conversion rate of oleic acid reaches 100%, and the selectivity of azelaic acid reaches 96%.

The application discloses a method for catalytic oxidative cleavage of aromatic ether substances. The method is that aromatic ether substances, metal-base composite catalysts and water medium are placed in an autoclave, and oxygen-containing gas is filled for hydrothermal reaction; the metal-base composite catalysts contain metal active components and base active components, wherein the metal active components are ruthenium, palladium, platinum, copper or cobalt, and the base active components are magnesium oxide, barium oxide or calcium oxide; the method can catalytically oxidize and cleave the aromatic ether substances into high-value-added small organic molecules such as phenols and carboxylic acids with high selectivity, and does not need to use organic solvent medium and add a large amount of inorganic base, and has the characteristics of simple process, high product added value and the like, and can produce important economic value and social benefits.

The application provides application of copper salt and alkaline metal salt, a photocatalyst for oxidative cleavage of aromatic hydrocarbon derivatives and a method for preparing benzoic acid derivatives, and relates to the technical field of plastic recycling. The application provides application of copper salt and alkaline metal salt (calcium chloride) with a molar ratio of 1:0-10 as a photocatalyst in photo-oxidative cleavage of aromatic hydrocarbon derivatives. When the copper salt and the alkaline metal salt are used in photo-oxidative cleavage of aromatic hydrocarbon derivatives, CuCl and chlorine free radicals generated by the copper salt (taking copper chloride as an example) under light irradiation, the chlorine free radicals act as hydrogen atom transfer reagents, activate C-H bonds of aromatic hydrocarbon derivatives and lignin model compounds to generate alkyl carbon free radicals, the alkyl carbon free radicals combine with O2 to form peroxide intermediates to obtain benzoic acid derivatives. The application also improves the activity of metal oxygen complex intermediates by using redox-inactive alkaline metal ions as Lewis acids, and further improves the yield of benzoic acid derivatives in cleavage products.

This invention discloses a method for the biosynthesis of high-purity L-threonate magnesium, belonging to the field of food fortification agents and biochemical synthesis technology. The invention uses L-xylorate calcium solution as a substrate, and obtains a purified L-threose solution through oxidative cleavage. Then, a complex dehydrogenase system composed of arabinose dehydrogenase, xylose dehydrogenase, and aldose dehydrogenase synergistically catalyzes the oxidation of L-threose to L-threonate. Finally, L-threonate magnesium is prepared by salt formation with magnesium hydroxide, crystallization, and drying. The purity of the obtained product is greater than 99.0%, the oxalic acid residue is less than 0.01%, the process is safe and environmentally friendly, and suitable for industrial production.

The present application relates to the technical field of chemical engineering, and discloses a method for preparing aromatic aldehyde and aromatic acid from lignin. The method comprises the following steps: mixing lignin raw material with a heterogeneous solid catalyst, and generating aromatic aldehyde and aromatic acid through oxidative cleavage reaction; the lignin raw material contains C-type and G / S-type lignin; and the heterogeneous solid catalyst comprises nitrogen-doped activated carbon loaded with transition metal. The method provided by the present application uses waste seed shells of Euphorbiaceae plants rich in C / G / S-type lignin as raw material, has low raw material cost, and uses a heterogeneous solid catalyst which has low preparation cost and can be effectively separated from the product. The catalytic activity of the catalyst in the oxidative cleavage reaction is high. The method is a green and efficient method for preparing aromatic aldehyde and aromatic acid based on biomass, and is suitable for industrial production. The method provided by the present application can obtain valuable aromatic aldehyde and aromatic acid with high yield, and can be applied to the fields of food and medicine to meet market demand.

The invention provides a novel method for realizing conversion from tertiary alcohol to ester in one step through carbon-carbon bond oxidative cleavage. According to the method, the ester compound is prepared from the tertiary alcohol compound by reacting for 12-48 hours at 110-180 DEG C in the presence of a nitrate catalyst in an oxygen atmosphere, and the method has the following advantages: 1) the application range of a substrate is wide, and the yield of medium or above can be obtained; and 2) the method does not need additional addition of an initiator, an oxidant and the like, and has the advantages of simplicity in operation, high stability, capability of realizing gram-level scale amplification and the like. And 3) the method can realize functional group conversion of complex bioactive molecules.

The application discloses a tail gas acetylene preparation method and system, and belongs to the technical field of acetylene preparation. The method comprises the following steps: a pretreatment step, wherein a hydrocarbon-containing tail gas is subjected to a hydrogenation saturation reaction, a conversion reaction and a methanation reaction, so that the hydrocarbon-containing tail gas is converted into a raw material gas mainly composed of methane; meanwhile, reaction heat generated in the hydrogenation saturation reaction, the conversion reaction and the methanation reaction is used to self-heat the raw material gas to a temperature required for acetylene cracking; an acetylene cracking step, wherein the heated raw material gas is mixed with an oxygen-containing gas to perform oxidative cracking, so that a cracking gas containing acetylene is obtained; and a compression and concentration step, wherein the cracking gas containing acetylene is compressed and concentrated, so that an acetylene product is obtained. The tail gas acetylene preparation method and system can fully utilize hydrocarbon components in industrial tail gas to prepare acetylene, without separating effective components, so that raw material loss is avoided, a preheating process is simplified, and energy consumption and investment are reduced.

The invention provides a synthesis method of hydrofluoroether, which comprises the following steps: A) performing ozone cracking, separation and purification on a hexafluoropropylene dimer to obtain perfluoroalkyl acyl fluoride; the perfluoroalkyl acyl fluoride comprises trifluoroacetyl fluoride, pentafluoropropionyl fluoride, heptafluoroisobutyryl fluoride and trifluoromethyl fluoroformate; the perfluoroalkyl acyl fluoride comprises trifluoroacetyl fluoride, pentafluoropropionyl fluoride, heptafluoroisobutyryl fluoride and trifluoromethyl fluoroformate; b) reacting the perfluoroalkyl acyl fluoride with hexafluoropropylene oxide to obtain perfluoro-2-alkoxy propionyl fluoride as shown in a formula (I-1) or a formula (I-2); and C) reacting the perfluoro-2-alkoxy propionyl fluoride with an alkylating reagent to obtain the hydrofluoroether shown as a formula (II-1) or a formula (II-2). According to the method, the hexafluoropropylene dimer (HFPD) is subjected to ozone oxidative cracking to prepare the perfluoroalkyl acyl fluoride, and the perfluoroalkyl acyl fluoride further reacts with the HFPO to obtain the perfluoro-2-alkoxy propionyl fluoride, so that the reaction conditions are mild, the process is simple, and the method is safe and reliable; reaction selectivity is good, by-products are few, products are easy to separate, and yield is high.

The application provides a method for directly detecting lytic polysaccharide monooxygenase activity in a fermentation broth and identifying oxidation types based on secondary hydrolysis of a product, color development by coupling of a glycol oxidase and a horseradish peroxidase. The method comprises the following steps: (1) culturing a recombinant strain of lytic polysaccharide monooxygenase to obtain fermentation supernatant thereof; (2) performing an oxidative cleavage reaction on a sample to be tested and a polysaccharide substrate in the presence of an electron donor and copper ions to obtain a reaction solution containing cleavage products; (3) adding ascorbate oxidase to the reaction solution to terminate the cleavage reaction of the lytic polysaccharide monooxygenase; (4) adding a glycosidase to the supernatant containing the cleavage products to perform secondary hydrolysis to obtain the sample to be tested; (5) adding a GOOX-HRP color development solution and the sample to be tested in a 96-well plate, and performing kinetic detection by using an enzyme-labeled instrument to measure the absorbance value at 515 nm; and (6) quantifying and classifying the sample to be tested according to the absorbance value. T. reesei ​

The invention provides a method for preparing perfluoromethyl vinyl ether, which comprises the following steps: carrying out ozone cracking reaction by using perfluoroolefin as a raw material, and separating and purifying to obtain trifluoromethyl fluoroformate, the preparation method comprises the following steps: reacting trifluoromethyl fluoroformate with hexafluoropropylene oxide to obtain perfluoro-2-methoxypropionyl fluoride, and further carrying out pyrolysis decarboxylation on the perfluoro-2-methoxypropionyl fluoride to obtain the perfluoromethyl vinyl ether. The method for preparing trifluoromethyl fluoroformate through ozone oxidative cracking of perfluoroolefin is mild in reaction condition, good in selectivity, simple in process, safe and reliable, the product is easy to separate, and the yield is high. Other products related in the process, such as trifluoroacetyl fluoride and heptafluoroisobutyryl fluoride, are also very important industrial intermediates which are difficult to obtain; the trifluoromethyl fluoroformate is used for replacing carbonyl fluoride to prepare perfluoro-2-methoxypropionyl fluoride, so that the defects that carbonyl fluoride is high in toxicity and has potential safety hazards in production and use are overcome, and the whole process of PMVE is safe and reliable.

The invention provides a hydroxyl active oxygen molecule fresh-keeping device. The hydroxyl active oxygen molecule fresh-keeping device comprises an environment sensing unit, a control unit and an execution control unit. According to the hydroxyl active oxygen molecule fresh-keeping equipment disclosed by the invention, a dynamic molecule synergistic active gas environment taking hydroxyl free radicals and ozone as cores is generated and maintained in situ as required in a fruit and vegetable storage space through a special pulse device, a typical Criege mechanism reaction is followed, hydroxyl active oxygen (. OH + O3) and olefin double bonds are subjected to a selective oxidative cracking process, and a fresh-keeping effect is achieved. Molecular-level targeted removal of ethylene is realized; hydroxyl free radicals (. OH) are used as safe'elicitor 'to promote secondary metabolism of fruits and vegetables, activate PAL enzyme, activate oxidation resistance and induce a fresh-keeping action mechanism of SOD / CAT activity. The deep linkage of triple mechanisms of physical elimination of ethylene, biological sterilization and pathogen inhibition and physiological regulation activation stress resistance is realized, and the conversion from passive corrosion prevention to active stress resistance is realized.

The application belongs to the field of chemical engineering and fine chemical industry, and discloses a continuous production process of azelaic acid. The process comprises the following steps: continuously feeding oleic acid, tungsten-based catalyst, auxiliary agent and hydrogen peroxide into a pipeline reactor to perform an oxidative cracking reaction, the pipeline reactor has an inner diameter of 5-50 cm, a pipeline length of 1-3 km, and a static mixer is arranged in the pipeline every 80-120 m, and the reaction residence time is 10-100 min; after the reaction liquid is continuously separated, it is separated and purified through continuous vacuum rectification, continuous thin film evaporation and continuous two-stage extraction to obtain azelaic acid; and the process can realize stable operation for more than 12 hours. The application adopts an industrial pipeline reactor with an inner diameter of 5-50 cm and a length of 1-3 km, and a static mixer is arranged every 80-120 m, which solves the problems of easy clogging and large pressure drop of the microreactor while maintaining efficient mass transfer. Compared with the laboratory microreactor, the process can realize stable operation for more than 12 hours, realizing the technical leap from the laboratory to industrialization.

Provided herein are reactive aromatic molecules (e.g., substituted chrysene heterodimers) encodable as base-four sequences for the design and integrated synthesis of nucleic acids (e.g., DNA, RNA, hybrid DNA / RNA) and associated phospholipid bilayers (e.g., cellular membranes). For example, 3,6,9,12-tetrasubstituted chrysene is coupled with 6,12-disubstituted chrysene through π-electron stacking to form a base-four heterodimer. The orientation of the ring structure of the tetrasubstituted chrysene in this heterodimer comprises a base-two (binary) structure and the relative alignment of the ring structure of the disubstituted chrysene to the tetrasubstituted chrysene comprises a second independent base-two (binary) structure. This collectively results in a base-four (quaternary) complex composed of four independent reaction environments. Methods of forming the heterodimers (and conjugated systems) include coupling sidechains of ethoxylated alcohol by phosphorylation. This may result in phosphodiester linkages at the 6,12 positions and / or uncoupled phosphorylated sidechains of ethoxylated alcohol at the 3,9 positions of the reactive aromatic molecules. The uncoupled phosphorylated sidechains may polymerize with adjacent tetrasubstituted chrysene through phosphodiester linkages. Various methods for initiating a reaction (e.g., oxidative cleavage) within the assembly of these π-electron stacked heterodimers can be utilized to produce nucleic acid sequences from the stacked tetrasubstituted chrysenes along with an associated phospholipid structure from the coupled disubstituted chrysene. Also provided herein are encoding and decoding design relations that can be utilized to map the base-four substituted chrysene heterodimers to the base-four nucleic acids (e.g., DNA, RNA, hybrid DNA / RNA). The present disclosure also includes various methods of regulating the sequence of substituted heterodimers to produce a specific encoding type of nucleic acid (e.g., DNA, RNA, hybrid DNA / RNA) and direct the 5′-3′ polymerization direction. The present disclosure also includes polycyclic pharmaceutical molecular agents resultant from the structural correlations in deriving the base-four heterodimer for subsequent synthesis to a sequence of nucleic acids and phospholipids.

The invention provides a beta-diketone iron catalyst compound as well as a synthesis method and application thereof. The synthesis method comprises the following steps: in a protonic solvent or a mixed solution of a non-protonic solvent and a protonic solvent, under the action of inorganic salt, carrying out a reaction as shown in the specification on a compound 2 and ferric salt to obtain a compound 1. The beta-diketone iron catalyst compound disclosed by the invention can be used as a catalyst, so that an olefin compound is subjected to fragmentation reaction, and C (sp2)-C (sp3) bond oxidation fragmentation reaction of olefin is realized.

The application discloses a method for producing carbonyl compounds by olefin oxidative cleavage, which comprises the following steps: reacting olefins under the action of a catalyst and hydrazine in the presence of water and in an air atmosphere at room temperature to obtain carbonyl compounds. The method provides a new alternative method for cleavage of C=C bonds, and has the advantages of green and environmental protection, use of H2O as a solvent and use of oxygen in air as an oxidant, no need of high temperature and pure oxygen, simple reaction operation, safety, wide substrate adaptability, and suitability for industrial production and market promotion and application.

The invention discloses a method for directly preparing phenol and aldehyde or ketone by taking alkyl aromatic hydrocarbon as a raw material based on selective carbon-carbon bond oxidative cleavage reaction, which comprises the following steps of: mixing alkyl aromatic hydrocarbon with a general formula (I), a photocatalyst, hydrobromic acid and an organic solvent; reacting under the conditions that oxygen is used as an oxidizing agent and a light source is used for irradiation, and simultaneously preparing a phenolic compound with a general formula (II) and a ketone or aldehyde compound with a general formula (III). According to the method, a large amount of alkyl aromatic hydrocarbon is used as a raw material, phenol, aldehyde and ketone organic chemical raw materials are generated through reaction, and compared with a traditional synthesis method, the method has the advantages that the catalyst is low in price and easy to obtain, reaction conditions are mild, operation is easy and convenient, selectivity is good, safety is high and the like, and is suitable for large-scale synthesis of phenol, p-cresol, cyclohexanone and the like; wide application prospects are shown.

This disclosure provides a method for preparing trolox amides by electro-oxidation. In some embodiments, this disclosure allows the reaction to proceed with reduced or no oxidant, providing a cleaner production method compared to conventional methods.

The invention discloses a black sesame authenticity identification method based on melanin characteristic degradation products, and belongs to the technical field of food quality analysis and identification. The authenticity identification method comprises the following steps: adding a sample to be detected into a NaOH solution, and extracting in a water bath; filtering and collecting filtrate to obtain a melanin extracting solution; adding hydrogen peroxide into the melanin extracting solution, and carrying out oxidative cracking reaction; after the reaction is completed, adjusting the pH to be acidic, extracting, collecting an organic phase, evaporating a solvent to obtain a degradation product, and then fixing the volume by adopting methanol; and carrying out liquid phase analysis on the degradation product, and identifying the black sesame through melanin characteristic degradation product so as to realize true and false identification of the black sesame. The method can be applied to black sesame authenticity identification and black sesame authenticity identification in a complex food system, and has good application prospects and value.

The invention discloses highly oxidized polycyclic bird nest alkane type diterpenoid compounds as well as a preparation method and application thereof, the number of the highly oxidized polycyclic bird nest alkane type diterpenoid compounds is 18, and the highly oxidized polycyclic bird nest alkane type diterpenoid compounds are obtained by being separated from secondary metabolites of Cyathuusstriata. An activity experiment taking MPP + induced PC-12 as a neuroprotection model shows that striatoid T shows remarkable neuroprotection activity, the cell survival rate of striatoid T is 82.35% and is equivalent to that of positive control selegiline hydrochloride, and compounds 3, 13, 16 and 18 show relatively high activity, and the cell survival rates of the compounds 3, 13, 16 and 18 are 73.33%, 73.17%, 71.81% and 70.83% respectively. Besides, the striatoid L (14) is subjected to structural modification, a high-valence iodine reagent PhI (OAC) 2 is used for carrying out oxidative cracking reaction on the striatoid L, and two new carbon skeleton compounds 14a and 14b are generated through the reaction. The research results show that the bird nest alkane type diterpenoid compound can be used as a pilot active small molecule for neuroprotection.

The application provides a preparation of a nitrogen-doped carbon-coated FeCoNi alloy catalyst, which comprises the following steps: (1) synthesis of a nitrogen-doped carbon material carrier; (2) synthesis of the nitrogen-doped carbon-coated FeCoNi alloy catalyst: (2.1) drying and dehydrating treatment of 0.5-1.0 g of the nitrogen-doped carbon material carrier for 12 h, and then cooling for standby; (2.2) dissolving nickel nitrate, cobalt nitrate and iron nitrate in water according to a mass ratio of 1:1:1 to prepare an impregnation solution, loading the impregnation solution on the surface of the nitrogen-doped carbon material carrier through ultrasonic vibration, and then placing the nitrogen-doped carbon material carrier in a vacuum drying box with a temperature of 80-100 DEG C for drying for 3-5 h; (2.3) after drying, cooling to room temperature, grinding into a powder, and then raising the temperature of a tube furnace to 600-800 DEG C at a speed of 3 DEG C / min under the condition of nitrogen, keeping calcination for 5-6 h, and then cooling, and the catalyst prepared by the application can convert lignin into phenols under mild conditions, the main product is 4-ethylphenol, the conversion rate is higher than 99%, and the selectivity is 68.6%.