5 results about "Fucosterol" patented technology

Lipid nanoparticles (LNP) having an immune regulation function, presenting at least one immune ligand on the surface thereof, promoting activation of non-variant natural killer T cells (iNKT cells) and inducing an immune response, or mediating recognition, binding or internalization between the lipid nanoparticles and the immune cells, and regulating the functional state of the immune cells; the formulation of the lipid nanoparticles comprises at least one of a ceramide-based glycolipid family, a peptidomimetic, and fucosterol, and the formulation forms nanoparticles of 1-1000 nm by a mixing process. The invention provides a lipid nanoparticle formula for enhancing organ targeting, cell targeting or cell activity, a pharmaceutical composition prepared by using the formula and application of the pharmaceutical composition. The formulation can encapsulate and deliver active ingredients such as nucleic acids, gene editing system components and natural small molecules.

The invention relates to application of an FBN1 small molecule antagonist in preparation of a medicine for treating kidney diseases, the active ingredient of the medicine comprises the FBN1 small molecule antagonist, the FBN1 small molecule antagonist is fucosterol, and the medicine inhibits proliferation and activation of fibroblasts. The invention finds that the FBN1 micromolecule antagonist fucosterol can be efficiently combined with FBN1 and destroy a fibrosis microenvironment constructed by the FBN1, so that FBN1-mediated EGRF pathway activation and fibroblast proliferation are inhibited, and the fucosterol shows a good renal function protection effect, remarkably relieves renal fibrosis and delays disease progression, and has a treatment application value.

A method for feeding invertebrates or aquaculture organisms, comprising # providing a pollen substitute composition comprising a nutritionally effective amount of isofucosterol, fucosterol or a mixture thereof; and # administering the pollen substitute composition to invertebrates or aquaculture organisms; wherein the pollen substitute composition comprises a nutritionally effective amount at least one further sterol, preferably at least two further sterols selected from the group consisting of cholesterol, 24-Methylene-cholesterol, campesterol, stigmasterol and beta-sitosterol or a physiologically available conjugate of any of these sterols.

The invention discloses a preparation method and application of a plant extract fermentation product for promoting anti-aging of cats, and belongs to the technical field of animal health care product preparation. Comprising a metabolite (LA20FM) of a brown algae extract which has an anti-aging function and is fermented by bifidobacterium adolescentis LifeAge20 and other raw materials, including one or more of D-sphingosine, luteolin, epigallocatechin, syringic acid, leucine, fucosterol, resveratrol, nicotinamide and glutathione. The metabolite of the brown algae extract fermented by the bifidobacterium adolescentis LifeAge20 disclosed by the invention has a remarkable effect in the anti-aging aspect, and can improve the content of nicotinamide adenine dinucleotide in vascular endothelial cells of cats, the angiogenesis capability and the antioxidant capability; the activity of beta-galactosidase in cells and the content of senescence phenotype markers are reduced, and a multi-channel anti-aging effect is realized. The LA20FM and additives are added to prepare the health-care agent, so that the health-care agent is more beneficial to anti-aging of pets and has a wide application prospect.

The invention discloses a preparation method and application of a plant extract fermentation product for promoting aging resistance of dogs, and belongs to the technical field of animal health care product preparation. Comprising a metabolite (LA20k9) of a brown algae extract which has an anti-aging function and is fermented by bifidobacterium adolescentis LifeAge20-k9 and other raw materials, and the metabolite is prepared from one or more of avenine, fucosterol, 3 ', 4', 5, 7-tetrahydroxyflavone, ciprofibrate, nicotinamide, epigallocatechin, leucine, syringic acid and glutathione. The metabolite of the brown algae extract fermented by the bifidobacterium adolescentis LifeAge20-k9 disclosed by the invention has a remarkable effect in the anti-aging aspect, and can improve the content of nicotinamide adenine dinucleotide in vascular endothelial cells of dogs, the angiogenesis capability and the antioxidant capability; the activity of beta-galactosidase in cells and the content of senescence phenotype markers are reduced, and a multi-channel anti-aging effect is realized. LA20k9 and additives are added to prepare the health-care agent, so that the health-care agent is more beneficial to aging resistance of pets and has a wide application prospect.