30 results about "Fucosterol" patented technology

The invention relates to the technical field of vegetable-oil soft capsules, in particular to a peony-seed-oil soft capsule and a preparation method thereof. The peony-seed-oil soft capsule is prepared by mixing and gelling of raw materials, capsule pressing and forming, hardening, sizing, scrubbing and drying. The peony-seed-oil soft capsule comprises the following raw materials in parts by weight: 80-95 parts of peony seed oil, 1-3 parts of fucosterol, 1-3 parts of squalene, 1-3 parts of propyl gallate, 0.05-0.25 part of tocopherol, 0.05-0.25 part of soya bean lecithin, 0.15-0.25 part of vitamin C, 5-10 parts of gelatin, 5-10 parts of water, 1.3-2.5 parts of sorbierite, and 2.5-5 parts of glycerol. The peony-seed-oil soft capsule is nutritious and safe, has the obvious effects of reducing blood fat, blood pressure and cholesterol, and can enhance the self immunity, prevent the diabetes, prevent and treat cancers, reduce weight, prevent cerebral stroke and myocardial infarction, clear harmful substances in blood, prevent and treat heart diseases and relieve the climacteric syndrome.

The invention discloses a method for extracting fucasterol from seaweed. Said invention adopts the techniques of chromatography and crystallization, etc to quickly extract fucosterol from natural material seacoeed, and has the advantages of rapid separation speed, low separation cost and rich and easily-available raw material and characterized by high product purity (purity is greater than 90%), regular crystal (white needle crystal) and small melting point range of 113-114 deg.C, etc. Said invention can be suitably used as fucosterol slandard prduct and raw material for making medicine. In the technological process related to said invention the single silica-gel column chromatographic separation method is adopted, the product can be crystallized by adopting one-ste process and monobasic solvent (ethyl alcohol), said product has no any toxic harms.

The invention discloses a hand sanitizer applied to medical clinical laboratory. The hand sanitizer consists of the following raw materials in parts by weight: 10-20 parts of scapharca subcrenata extract freeze-dried powder, 10-15 parts of fucosterol, 4-15 parts of carboxymethyl chitosan, 7-11 parts of juice of awned goosefoot, 5-10 parts of chitosan, 5-8 parts of polysaccharides of sargassum graminifolium, 30-68 parts of water of washing rice, 2-5 parts of chlorhexidine acetate, 5-10 parts of an extract of broadleaf holly leaves, 5-10 parts of cocamidopropyl betaine, 4-8 parts of an extract of fructus rubi, 4-6 parts of herba portulacae juice, 2-5 parts of jellyfish collagen, 2-5 parts of coconut shell activated carbon and 1-3 parts of guar gum. The hand sanitizer provided by the invention has a good sterilizing effect and is long in bacteriostasis duration; meanwhile, the hand sanitizer has moisturizing and nourishing effects; and the hand sanitizer, when used, is free from any sideeffects and discomfort; therefore, the hand sanitizer is safer.

An object of the present invention is to provide a novel method for producing a steroid compound. The present invention provides a method for producing 3,7-dioxo-5β-cholanic acid or ester derivatives thereof, which uses, as raw materials, sterols having double bonds at positions 5 and 24, such as cholesta-5,7,24-trien-3β-ol, ergosta-5,7,24(28)-trien-3β-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3β-ol, and which comprises the following 4 steps: (I) a step of performing oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4; (II) a step of converting position 24 to a carboxyl group or an ester derivative thereof by the oxidative cleavage of a side chain; (III) a step of introducing an oxygen functional group into position 7; and (IV) a step of constructing a 5β-configuration by reduction of a double bond at position 4.

The invention provides a novel process for the production of steroids, namely, a process for the production of 5ss-3,7 -dioxocholanoic acid or ester derivatives thereof which comprises using as the raw material a sterol having double bonds at the 5- and 24-positions selected from among cholesta -5,7,24-trien-3ss-ol, ergosta-5,7,24(28)-trien-3ss-ol, desmo- sterol, fucosterol, and ergosta-5,24(28)-dien-3ss-ol and conducting the following four steps: (I) the step of conducting the oxidation of 3-position hydroxyl and the isomerization of double bond from the 5-position to the 4-position (II) the step of converting the group at the 24-position into carboxyl or a carboxylic ester group by oxidative cleavage of the side chain, (III) the step of introducing an oxygen-containing functional group to the 7-position, and (IV) the step of constructing 5ss-configuration by reductive saturation of the 4-position double bond.

The invention discloses an Undaria pinnatifida bean milk powder and a processing method thereof. The Undaria pinnatifida bean milk powder is characterized in comprising the following raw materials by weight portion: 70 to 80 portions of soy beans, 15 to 20 portions of milk, 10 to 15 portions of white granulated sugar and 2 to 3 portions of Undaria pinnatifida. The processing method comprises the following steps: the soy beans are subjected to fine selection and then sequentially to drying, hull removal, deactivation of enzyme, crushing and pulping, fine milling and separation, modification, ultra-high temperature instantaneous sterilization, homogenization, vacuum concentration, vacuum low temperature drying, screening, weight checking and packing; and a proper amount of Undaria pinnatifida bean powder is added before high temperature sterilization and after the separation of soybean dregs. The milk powder is added with the Undaria pinnatifida bean milk powder which contains a large amount of active substances and alginic acid and fucosan in pectin. The frond of the Undaria pinnatifida also contains fucosterol, laminine, chlorophyll, EPA and so on. Particularly, the alginic acid, the fucosan, the fucosterol and other substances have functions of blood pressure reduction, cholesterin reduction, blood viscosity reduction, cancer resistance, diabetes prevention and so on.

The invention belongs to the technical field of medical preparations, and particularly relates to an agomelatine transdermal patch and a preparing method thereof. The preparing method comprises the following steps of micronizing an agomelatine crystal of a specific crystal form; dispersing the micronized crystal into a mixture of fucosterol, octanoic acid, 2-pyrrolidone and isopropanol; coating amacromolecule pressure-sensitive adhesive with a product to obtain the patch. According to the agomelatine transdermal patch and the preparing method thereof, the transdermal absorption rate of agomelatine is high, the agomelatine absorption amount is high, the patch has the advantages of being stable, efficient, high in uniformity and low in irritation, and wide clinical application is facilitated.

The invention discloses a method for detecting nine nutrients in edible vegetable oil. The method comprises the following steps: (1) dissolving the edible vegetable oil into a mixed solvent of cyclohexane and ethyl acetate, so as to obtain an edible vegetable oil solution, wherein the volume ratio of cyclohexane to ethyl acetate is 1 to 1; (2) injecting the edible vegetable oil solution prepared in the step (1) into a preparation type gel permeation chromatographic instrument, and dissolving residue of the blow-dried effluent, and filtering to obtain a target analyzing solution, wherein the purification conditions are that a gel chromatographic column is 300mm*20mm, the feeding volume is 5mL, the mixed solvent of cyclohexane and ethyl acetate serves as a moving phase, the flow speed is 4.7mL per minute, the collection time of effluent is from seven forty to fifteen o'clock; and (3) injecting the target analyzing solution obtained in the step (2) into a liquid chromatogram-mass spectrometer, measuring, and analyzing the contents of the nine nutrients, namely erythrodiol, arbutin, ergosterol, brassicasterol, campesterol, fucosterol, stigmasterol, cholesterin and beta-sitosterol by virtue of an external standard method.

It is an object of the present invention to provide a novel method for producing a steroid compound. The present invention provides a method for producing 5β-3,7-dioxocholanic acid or an ester derivative thereof, using, as a raw material, a sterol having double bonds at position 5 and at position 24, such as cholesta-5,7,24-trien-3β-ol, ergosta-5,7,24(28)-trien-3β-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3β-ol, via the following 4 steps:(I) a step involving oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4;(II) a step involving the oxidative cleavage of a side chain to convert position 24 to a carboxyl group or an ester derivative thereof;(III) a step of introducing an oxygen functional group into position 7; and(IV) a step of constructing a 5β configuration by reductive saturation of a double bond at position 4.

The present invention relates to a composition for preventing or treating muscle diseases or improving muscular function, containing fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract. According to the present invention, fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function. In addition, since the composition of the present invention is a natural product, the composition can be safely used without side effects, thereby being usable in medicine, food, cosmetic products, livestock feed, a feed additive and the like.

The present invention relates to a novel use of fucosterol and, more specifically, to a composition for skin whitening or composition for skin moisturizing, which is characterized by containing fucosterol. Fucosterol of chemical formula 1 below has an excellent whitening effect of inhibiting melanin generation and tyrosinase activity, and thus can be used as an active ingredient of a cosmetic composition for whitening, a food composition, or a pharmaceutical composition. Furthermore, the fucosterol of chemical formula 1 below has an excellent moisturizing function by forming dead skin cell membranes, promoting the differentiation of dead skin cells, and generating natural moisturization factors, and thus can be used as an active ingredient of a cosmetic composition for moisturizing, a food composition, or a pharmaceutical composition

An object of the present invention is to provide a novel method for producing a steroid compound. The present invention provides a method for producing 3,7-dioxo-5beta-cholanic acid or ester derivatives thereof, which uses, as raw materials, sterols having double bonds at positions 5 and 24, such as cholesta-5,7,24-trien-3beta-ol, ergosta-5,7,24(28)-trien-3beta-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3beta-ol, and which comprises the following 4 steps: (I) a step of performing oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4; (II) a step of converting position 24 to a carboxyl group or an ester derivative thereof by the oxidative cleavage of a side chain; (III) a step of introducing an oxygen functional group into position 7; and (IV) a step of constructing a 5beta-configuration by reduction of a double bond at position 4.

The invention relates to the technical field of medical supplies and in particular relates to peony cell viability liquid and a preparation method thereof. The peony cell viability liquid is preparedfrom peony seed oil containing the following components in percentage by weight: 25-30% of peony saponins, 10-30% of peony polysaccharide, 15-25% of fucosterol, 2-8% of @ linolenic acid, 5-15% of linoleic acid and 6-10% of vitamins. The peony seed extract, peony flower extract, peony leaf extract and peony root extract have excellent biocompatibility, flexibility and film-forming properties, havecertain effects of resisting bacteria, diminishing inflammation and stopping bleeding, and can achieve the effects of promoting wound tissue regeneration, repair and healing; mixture of the wound andbacteria can be isolated, the wound surface is protected, and pain is relieved; and moreover, the peony cell viability liquid disclosed by the invention does not contain any preservative, and becausethe peony cell viability liquid is a natural system with low moisture content, the liquid is hydrophilic, can be mixed and dissolved with water according to any ratio, contains physiologically safe phospholipids and plant-derived polyhydric alcohols, and is natural and non-irritating.

The invention relates to the technical field of vegetable-oil soft capsules, in particular to a peony-seed-oil soft capsule and a preparation method thereof. The peony-seed-oil soft capsule is prepared by mixing and gelling of raw materials, capsule pressing and forming, hardening, sizing, scrubbing and drying. The peony-seed-oil soft capsule comprises the following raw materials in parts by weight: 80-95 parts of peony seed oil, 1-3 parts of fucosterol, 1-3 parts of squalene, 1-3 parts of propyl gallate, 0.05-0.25 part of tocopherol, 0.05-0.25 part of soya bean lecithin, 0.15-0.25 part of vitamin C, 5-10 parts of gelatin, 5-10 parts of water, 1.3-2.5 parts of sorbierite, and 2.5-5 parts of glycerol. The peony-seed-oil soft capsule is nutritious and safe, has the obvious effects of reducing blood fat, blood pressure and cholesterol, and can enhance the self immunity, prevent the diabetes, prevent and treat cancers, reduce weight, prevent cerebral stroke and myocardial infarction, clear harmful substances in blood, prevent and treat heart diseases and relieve the climacteric syndrome.

The invention discloses application of a highland barley bran extract for preparing an alpha-glucosidase activity inhibitor, and particularly relates to a medicine for preparing a medicine, a health care product or a food for preventing and / or treating type-II diabetes. The highland barley bran extract comprises, by mass, 10-60% of total sterol. The total sterol comprises beta-sitosterol, campesterol, fucosterol, stigmasterol and desmosterol.

The invention relates to a method for extracting fucosterol from bladder-wrack, which is simple and convenient to operate and has small pollution and low energy consumption. The method comprises the following steps of: smashing bladder-wrack; adding into a CO2 supercritical extractor to obtain an extract by taking ethanol as an entrainer; performing level 6 countercurrent extraction by using water-saturated n-butyl alcohol; collecting a n-butyl alcohol layer; recovering a solvent under reduced pressure; adding onto an AB8 macroporous absorption resin column; eluting at 50 percent; collecting an eluent; recovering ethanol under reduced pressure and concentrating; adding methanol for crystallizing; separating a crystal; and washing and drying to obtain the fucosterol. By adopting the method for preparing fucosterol, the product purity is high, and industrial amplification is easy to realize.

The invention belongs to the technical field of biology, and discloses a method for producing fucosterol drug intermediates and algal polysaccharides, which comprises the following steps: step 1) culturing sargassum thunbergii, step 2) preparing algal powder, step 3) preparing a fucosterol crude product, step 4) purifying fucosterol, and step 5) separating algal polysaccharides. According to the method disclosed by the invention, the synthesis efficiency of the fucosterol is improved, algal polysaccharides are obtained while the fucosterol is separated and extracted, and the co-production of two effective substances is realized.

The invention relates to the technical field of healthcare products, in particular to peony seed oil concentrate with a cell repairing function and a preparation method thereof. The peony seed oil concentrate comprises peony seed oil glucoside, cortex moutan polyphenol, squalene, vitamin a / e / f, fucus evanescens sterol and peony essential oil. The peony seed oil concentrate has the advantages thatthe peony seed oil concentrate contains various active components, peony seed oil contains a large number of cell growth factors, the epithelial cells, endothelial cells, hematopoietic cells and the like in the skin can be repaired, a good skin repairing effect is achieved, the skin repairing function of the cells is promoted, skin activity recovery is achieved, harmful substances retained on thesurface of the skin are reduced, and severe itching and allergy can be relieved fast; by the preparation method, cell repairing is achieved while cell activity can be kept for a long time, the aging of the cell growth factors is slowed down, the peony seed oil concentrate is long in shelf time, and the curative effect of the peony seed oil concentrate can be well brought into play.

An object of the present invention is to provide a novel method for producing a steroid compound. The present invention provides a method for producing 3,7-dioxo-5β-cholanic acid or ester derivatives thereof, which uses, as raw materials, sterols having double bonds at positions 5 and 24, such as cholesta-5,7,24-trien-3β-ol, ergosta-5,7,24(28)-trien-3β-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3β-ol, and which comprises the following 4 steps: (I) a step of performing oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4; (II) a step of converting position 24 to a carboxyl group or an ester derivative thereof by the oxidative cleavage of a side chain; (III) a step of introducing an oxygen functional group into position 7; and (IV) a step of constructing a 5β-configuration by reduction of a double bond at position 4.

The present invention relates to a novel use of fucosterol and, more specifically, to a composition for skin whitening or composition for skin moisturizing, which is characterized by containing fucosterol. Fucosterol of chemical formula 1 below has an excellent whitening effect of inhibiting melanin generation and tyrosinase activity, and thus can be used as an active ingredient of a cosmetic composition for whitening, a food composition, or a pharmaceutical composition. Furthermore, the fucosterol of chemical formula 1 below has an excellent moisturizing function by forming dead skin cell membranes, promoting the differentiation of dead skin cells, and generating natural moisturization factors, and thus can be used as an active ingredient of a cosmetic composition for moisturizing, a food composition, or a pharmaceutical composition

The invention discloses a method for detecting nine nutrients in edible vegetable oil. The method comprises the following steps: (1) dissolving the edible vegetable oil into a mixed solvent of cyclohexane and ethyl acetate, so as to obtain an edible vegetable oil solution, wherein the volume ratio of cyclohexane to ethyl acetate is 1 to 1; (2) injecting the edible vegetable oil solution prepared in the step (1) into a preparation type gel permeation chromatographic instrument, and dissolving residue of the blow-dried effluent, and filtering to obtain a target analyzing solution, wherein the purification conditions are that a gel chromatographic column is 300mm*20mm, the feeding volume is 5mL, the mixed solvent of cyclohexane and ethyl acetate serves as a moving phase, the flow speed is 4.7mL per minute, the collection time of effluent is from seven forty to fifteen o'clock; and (3) injecting the target analyzing solution obtained in the step (2) into a liquid chromatogram-mass spectrometer, measuring, and analyzing the contents of the nine nutrients, namely erythrodiol, arbutin, ergosterol, brassicasterol, campesterol, fucosterol, stigmasterol, cholesterin and beta-sitosterol by virtue of an external standard method.

The invention belongs to the technical field of biological culture of algae, and discloses a technology for increasing the efficiency of synthesizing fucosterol from sargassum thunbergii. The technology comprises steps as follows: the sargassum thunbergii is inoculated to a sargassum thunbergii culture solution for culture, and algae are collected; and the sargassum thunbergii culture solution isprepared by extra addition of sodium metasilicate nonahydrate and triammonium phosphate on the basis of f / 2 culture medium. Nutrient substances and illumination conditions of a cultivating environmentare regulated and controlled purposefully in the cultivating process of sargassum thunbergii seedlings, and by means of appropriate nutritive salt concentration and proportion, higher fucosterol synthesis rate can be realized.

The invention relates to a hair nourishing and care composition based on marine biological active substances and application of the composition in hair washing care products. The hair care composition is prepared from, by weight, (A) water-soluble marine biological active substances 25%-75% including (i) seaweed glycoprotein 10%--30%, (ii) trehalose 10%-30% and (iii) chitosan derivatives 5.0%-15%, (B) oil-soluble marine biological active substances 0.02%-1.0% including (i) 0.01-0.5% fucosterol and (ii) astaxanthin 0.01-0.5%, (C) suspended carrier coating seaweed gel 0.5%-5.0%; and (D) the balance water. The hair nourishing and care composition has oil absorption and oil control properties, and a fluffy and rich washing and protecting effect is strengthened.

A composition for preventing or treating muscle diseases or improving muscular function, containing fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract is disclosed. Fucosterol, Sargassum fulvellum, a Sargassum fulvellum dried powder, a Sargassum fulvellum extract, Sargassum fusiforme, a Sargassum fusiforme dried powder or a Sargassum fusiforme extract increases the protein expression of p-mTOR, which is a main gene involved in muscle protein synthesis, inhibits the mRNA expression of MuRF-1 and atrogin-1 involved in muscle protein degradation, and increases the mRNA expression of MyoD and myogenin involved in muscle differentiation, thereby having an effect of remarkably increasing muscular function. In addition, the composition can be safely used without side effects, thereby being usable in medicine, food, cosmetic products, livestock feed, a feed additive and the like.

The invention discloses an application of a pecan sterol extractive in preparation of anti-inflammatory materials. The anti-inflammatory materials comprise anti-inflammatory drugs, anti-inflammatory daily cosmetics or anti-inflammatory healthcare products. A weight content of a total sterol in the pecan sterol extractive is 10-50%; the total sterol comprises beta-sitosterol, fucosterol, campesterol and stigmasterol; a weight content of the sitosterol in the total sterol is 70-95%; and a weight ratio of the beta-sitosterol to the fucosterol to the campesterol to the stigmasterol is (70-95):(1-10):(2-12):(1-15).

The invention discloses application of a highland barley bran extract for preparing an alpha-glucosidase activity inhibitor, and particularly relates to a medicine for preparing a medicine, a health care product or a food for preventing and / or treating type-II diabetes. The highland barley bran extract comprises, by mass, 10-60% of total sterol. The total sterol comprises beta-sitosterol, campesterol, fucosterol, stigmasterol and desmosterol.

The invention discloses an application of a pecan sterol extractive in preparation of anti-inflammatory materials. The anti-inflammatory materials comprise anti-inflammatory drugs, anti-inflammatory daily cosmetics or anti-inflammatory healthcare products. A weight content of a total sterol in the pecan sterol extractive is 10-50%; the total sterol comprises beta-sitosterol, fucosterol, campesterol and stigmasterol; a weight content of the sitosterol in the total sterol is 70-95%; and a weight ratio of the beta-sitosterol to the fucosterol to the campesterol to the stigmasterol is (70-95):(1-10):(2-12):(1-15).

The invention discloses a paeonia suffruticosa seed oil facial mask. The paeonia suffruticosa seed oil facial mask consists of the following components in percentage by mass of 2-5% of vitamin E, 20-30% of paeonia suffruticosa seed oil, 15-25% of fucosterol, 30-50% of hyaluronic acid, and 10-20% of a calendula extract, wherein the sum of the components in percentage is 100%. A preparation method of the paeonia suffruticosa seed oil facial mask comprises the following steps of stirring the paeonia suffruticosa seed oil and the fucosterol at 30-50 DEG C until the paeonia suffruticosa seed oil and the fucosterol dissolve, after stirring is finished, placing a mixture in an emulsifying pot, and performing complete emulsifying to obtain a material A; and sequentially adding the material A, andthe calendula extract to the hyaluronic acid, performing stirring for 30-60min,and after stirring is completed, performing cooling to normal temperature so as to obtain a paeonia suffruticosa seed oilapplying type facial mask. The paeonia suffruticosa seed oil and the fucosterol are emulsified under the heating state, so that favorable oil removing effect can be achieved; and through combinationof the vitamin E and the calendula extract, the treatment effects of whitening skin, resisting bacteria and diminishing inflammation can be achieved.

The invention discloses a method for extracting fucasterol from seaweed. Said invention adopts the techniques of chromatography and crystallization, etc to quickly extract fucosterol from natural material seacoeed, and has the advantages of rapid separation speed, low separation cost and rich and easily-available raw material and characterized by high product purity (purity is greater than 90%), regular crystal (white needle crystal) and small melting point range of 113-114 deg.C, etc. Said invention can be suitably used as fucosterol slandard prduct and raw material for making medicine. In the technological process related to said invention the single silica-gel column chromatographic separation method is adopted, the product can be crystallized by adopting one-ste process and monobasic solvent (ethyl alcohol), said product has no any toxic harms.