Method for producing steroid compound

A compound and cholesteric technology, applied in the field of preparation of steroids, can solve the problems of limited application and the like
CN101018802AInactive Publication Date: 2007-08-15MITSUBISHI CHEM CORP
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
MITSUBISHI CHEM CORP
Publication Date
2007-08-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

An object of the present invention is to provide a novel method for producing a steroid compound. The present invention provides a method for producing 3,7-dioxo-5beta-cholanic acid or ester derivatives thereof, which uses, as raw materials, sterols having double bonds at positions 5 and 24, such as cholesta-5,7,24-trien-3beta-ol, ergosta-5,7,24(28)-trien-3beta-ol, desmosterol, fucosterol, or ergosta-5,24(28)-dien-3beta-ol, and which comprises the following 4 steps: (I) a step of performing oxidation of a hydroxyl group at position 3 and isomerization of a double bond at position 5 to position 4; (II) a step of converting position 24 to a carboxyl group or an ester derivative thereof by the oxidative cleavage of a side chain; (III) a step of introducing an oxygen functional group into position 7; and (IV) a step of constructing a 5beta-configuration by reduction of a double bond at position 4.
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Description

technical field

[0001] The present invention relates to a method for preparing steroids, in particular, to a method for preparing 3,7-dioxo-5β-cholestanoic acid or its ester derivatives, which is obtained by adding a steroid with a double bond at the 4-position The compound is reductively saturated to carry out the construction of the 5β stereo. More specifically, it relates to a method for preparing 3,7-dioxo-5β-cholestanoic acid or its ester derivatives. The method is based on the 5-position and 24 Cholesta-5,7,24-trien-3β-ol, or ergosta-5,7,24(28)-trien-3β-ol, streptosterol or fucosterol of sterols with a double bond , Ergosta-5,24(28)-diene-3β-alcohol is raw material, and through following 4 steps, namely:

[0002] (1) carry out the step of the oxidation of 3-position hydroxyl and the isomerization of 5-position double bond to 4-position;

[0003] (II) a step of changing the 24-position into a carboxyl group or an ester derivative thereof by oxidative cleavage of the sid...

Claims

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