N1,N8-disubstituent-triethyl tetramine copper (II) complex and its prepn process

A technology of triethylenetetramine and di-substitution, which is applied in the direction of copper organic compounds, medical preparations containing active ingredients, and pharmaceutical formulas. It can solve problems such as research difficulties, low content, and complex structures, and achieve a simple and easy synthesis method. line, easy purification, and high-yield results
CN1974576AInactive Publication Date: 2007-06-06长治学院
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
长治学院
Publication Date
2007-06-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to N1, N8-disubstitutent-triethyl tetramine copper (II) complex as one kind of small molecular polyamine metal complex. Research shows that N1, N8-disubstitutent-triethyl tetramine copper (II) complex may be combined with DNA at the major groove in the insertion mode, the DFT process confirms the action mode between the complex and DNA, gel electrophoresis process shows that the complex can incise DNA, and MTT process proves the cancer cell inhibiting effect of the complex, so that the complex may be used in developing effective chemical nuclease and high efficiency and low toxicity anticancer medicine.
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Description

technical field

[0001] The present invention relates to a copper (II) complex of symmetrical polyamines, in particular to a N 1 , N 8 - Disubstituted triethyltetraamine copper (II) complexes, the invention also relates to a process for the preparation of the complexes. Background technique

[0002] Cancer is one of the major diseases that threaten human life. In today's diseases, the fatality rate of cancer accounts for about 25%, which shows its great harm. With the understanding of tumor molecular biology, remarkable achievements have been made in cancer chemotherapy, and many drugs have been used in clinical treatment. However, it has been found that the anticancer agents used generally have the disadvantage of low selectivity to tumor cells, and almost all anticancer drugs also kill normal cells while killing cancer cells. Therefore, improving the selectivity of anticancer drugs and developing anticancer drugs with high efficiency and low toxicity have become the focu...

Claims

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