Bis(2-acetylpyrazine) thiocarbonohydrazone and preparation method and application of bismuth (III) complex thereof
A technology based on thiobisemicarbazone and acetylpyrazine, which is applied in the fields of bismuth organic compounds, drug combinations, organic chemistry, etc., can solve the problems of few literature reports, difficult synthesis, difficult cultivation, etc., and achieve a strong growth inhibitory effect Effect
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Embodiment 1
[0038] The preparation method of two (2-acetylpyrazinyl) thiobisemicarbazones, it comprises the steps:
[0039] 1) Synthesize the required 1.3-symmetric dithiosemicarbazide according to the literature method (see Sheng Mei, Jiang Yanqing, Lu Zhengwei, Journal of Jiangsu Institute of Technology , 2004, 16(1) : 35-39);
[0040] 2) Add 1.3-symmetric dithiosemicarbazide (1.00 g, 10 mmol) and 2-acetylpyrazine (2.40 g, 20 mmol) into a flask containing 50 mL of ethanol at room temperature, and then add 0.35 mL of glacial acetic acid dropwise , Mixed and then stirred and refluxed for 4h, cooled, filtered, and the precipitate was recrystallized with ethanol and dried in vacuum to obtain an orange-red powder with a yield of about 75%. Elemental analysis results measured value: C 49.87, H 4.18, N 35.78; calculated value C 13 h 13 N 8 S (%): C 49.97, H 4.09, N 35.90; IR (KBr, cm -1 ): ν (C=N) 1614 cm -1 , ν (C=S) 852 cm -1 , ν (N=N) 1104 cm -1 .
[0041] The preparation m...
Embodiment 2
[0044] The preparation method of two (2-acetylpyrazinyl) thiobisemicarbazones, it comprises the steps:
[0045] 1) Synthesize the required 1.3-symmetric dithiosemicarbazide according to the literature method (see Sheng Mei, Jiang Yanqing, Lu Zhengwei, Journal of Jiangsu Institute of Technology , 2004, 16(1) : 35-39);
[0046] 2) Add 1.3-symmetric dithiosemicarbazide (1.00 g, 10 mmol) and 2-acetylpyrazine (3.00 g, 25 mmol) into a flask containing 50 mL of methanol at room temperature, and then add 0.35 mL of glacial acetic acid dropwise , Mixed and then stirred and refluxed for 4h, cooled, filtered, and the precipitate was recrystallized with methanol and then vacuum-dried to obtain an orange-red powder with a yield of about 81%. Elemental analysis results measured value: C 49.87, H 4.18, N 35.78; calculated value C 13 h 13 N 8 S (%): C 49.97, H 4.09, N 35.90; IR (KBr, cm -1 ): ν (C=N) 1614 cm -1 , ν (C=S) 852 cm -1 , ν (N=N) 1104 cm -1 .
[0047] The preparati...
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