Alpha,beta-diamino acid derivative and synthetic method and application thereof

A technology of diamino acid and synthetic method, applied in the field of alpha, can solve the problems of unfriendly environment, high cost, poor universality of substrates, etc.
CN102432485AInactive Publication Date: 2012-05-02EAST CHINA NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
EAST CHINA NORMAL UNIV
Publication Date
2012-05-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a synthetic method of an alpha, beta-diamino acid derivative. In the method, a one-step reaction is undergone by taking a diazo compound, aniline and aldehyde acid ester as raw materials, taking metal Lewis acid and chiral phosphoric acid as catalysts, taking an organic solvent as a solvent and taking a 4 Angtrom molecular sieve as a water absorbing agent, so that the alpha, beta-diamino acid derivative is obtained. The synthetic method disclosed by the invention has the advantages of high atom economy, high selectivity and high yield, the reaction conditions are mild, and operation is easy and safe. The alpha, beta-diamino acid derivative has anticancer activity and structural diversity, and is suitable for preparing and applying antitumor, antibiotic and antifungal medicaments.
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Description

technical field

[0001] The invention belongs to the field of synthetic medicine and chemical industry, and mainly relates to an α, β-diamino acid derivative and its synthesis method and application. Background technique

[0002] α, β-Diamino acid derivatives are a kind of important skeleton structures for building natural products and synthetic drugs, and many marine organisms and natural antibiotics contain such skeleton structures. For example, there are such skeleton structures in many drug structures such as antineoplastic drugs bleomycin and peplomycin, and tuberculosis drug viomycin. α,β-Diamino acid derivatives can also be used in the synthesis of numerous other antineoplastic drugs, antibiotics, antifungal drugs. In addition, α,β-diamino acid derivatives can be used as ligands (Inorg. Biochem. 1995, 57, 279.) and synthetic building blocks to synthesize a series of biologically active compounds. In addition, it has a strong chelation effect with metals, and this pro...

Claims

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