Bacterium AD05 which is separated from human intestinal tract and can generate anti-cancer active metabolites and application of bacterium AD05

A metabolite, anti-cancer activity technology, applied in the direction of microbial-based methods, medical preparations containing active ingredients, bacteria, etc., can solve the problem that the curative effect does not reach the cure of diseases

Inactive Publication Date: 2016-03-02
HARBIN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Twenty years later, a New York physician used streptococcal pyrogens to treat inoperable cancer patients, but the efficacy did not achieve the effect of curing

Method used

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  • Bacterium AD05 which is separated from human intestinal tract and can generate anti-cancer active metabolites and application of bacterium AD05
  • Bacterium AD05 which is separated from human intestinal tract and can generate anti-cancer active metabolites and application of bacterium AD05
  • Bacterium AD05 which is separated from human intestinal tract and can generate anti-cancer active metabolites and application of bacterium AD05

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Isolation and Identification of Example 1 Bacteria AD05

[0030] (1) Isolation and cultivation of bacteria AD05

[0031] 1. Method

[0032] (1) Take healthy human feces as samples, and isolate and culture bacteria from them.

[0033] Sampling Instructions:

[0034] We will give each stool donor a sampling package, including the following items: 50mL centrifuge tube x1, spoon x1, PE gloves x2, paper tray x1, informed consent form x1, and sampling instructions x1.

[0035] Instructions:

[0036] 1) Read the informed consent form in detail, sign the stool provider and fill in the basic information in detail.

[0037] 2) Please try to discharge the feces into a disposable paper tray.

[0038] 3) Put on PE gloves, dig out about 10g of feces with a spoon (approximately reaching the 10mL scale line of the centrifuge tube), put it into a 50mL centrifuge tube, tighten the cap of the centrifuge tube, and put it back into the ziplock bag.

[0039] 4) Try to avoid touching ot...

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Abstract

The invention discloses a bacterium AD05 which is separated from a human intestinal tract and can generate anti-cancer active metabolites and application of the bacterium AD05. Feces of healthy persons is used as a sample and is screened by the aid of first Gauserime solid culture media with potassium dichromate, so that the bacterium which can generate the anti-cancer active metabolites can be ultimately separated from the human intestinal tract and is named as AD05. The bacterium AD05 and the application have the advantages that the bacterium AD05 has the closest genetic relationship with Fimbriimonas ginsengisoli Gsoil 348 as discovered in 16S rRNA (ribosomal ribonucleic acid) comparison, and obvious anti-tumor activity of the bacterium AD05 and the metabolites of the bacterium AD05 is sufficiently proved by experiments; the bacterium is sourced from the human intestinal tract and accordingly has little or zero side effects for human bodies; a novel technical means is provided for tumor therapy, and important effects can be realized for development of biological tumor therapy.

Description

technical field [0001] The invention belongs to the field of biopharmaceuticals, and isolates bacteria capable of producing anticancer active metabolites from human intestinal bacteria Background technique [0002] Cancer has become an extremely serious disease worldwide, and the incidence of cancer continues to rise. In recent decades, the incidence of cancer has shown a linear upward trend. According to the "2012 China Cancer Registration Annual Report", the incidence rate of cancer in my country is 285.91 / 100,000, and the urban and rural incidence rates are 303.91 / 100,000 and 249.98 / 100,000, respectively. According to the "2011 China Cancer Registration Annual Report", the cancer mortality rate in China is 184.67 / 100,000. It is worth noting that although the incidence of cancer in urban areas is higher than that in rural areas, the mortality rate is lower than in rural areas (181.54 / 100,000 vs. 196.34 / 100,000). It is estimated that by 2049, the incidence of cancer in my...

Claims

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Application Information

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IPC IPC(8): C12N1/20C12P1/04A61K35/741A61P35/00A61P35/02C12R1/01
Inventor 刘树林周玉洁沐晓芹刘慧迪赵丹丹陈浩庭吴立军刘桂荣
Owner HARBIN MEDICAL UNIVERSITY
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