Halogen-substituted isoindoline compound and application thereof

A compound and halogen technology, applied in the field of medicine, can solve the problem of halogen-substituted isoindoline compounds and the like
CN114835680APending Publication Date: 2022-08-02CHENGDU FENDI PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
CHENGDU FENDI PHARM CO LTD
Publication Date
2022-08-02

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Abstract

The invention relates to a halogen-substituted isoindoline compound as shown in the following formula I and application of the halogen-substituted isoindoline compound. The compound provided by the invention has obviously more excellent anti-tumor activity, and can be prepared into an oral dosage form which is more convenient, safer and more economical for administration. Therefore, the utilization value is remarkably improved compared with that of the existing compound.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and particularly relates to halogen-substituted isoindoline compounds and applications thereof. Background technique

[0002] Protein mutations, expression imbalances, allosteric and functional abnormalities can cause many diseases. Protein synthesis or degradation is a tightly regulated process in both space and time during cell growth and proliferation. Dysregulation of these processes may lead to uncontrolled cell growth, proliferation, and migration, leading to diseases such as cancer, aging, and viral infections.

[0003] The translation termination factor GSPT1 (eRF3a) is closely related to diseases such as cancer, which mediates stop codon recognition and promotes the release of nascent peptides from ribosomes. In addition to its translation termination function, GSPT1 is involved in several other key cellular processes, such as cell cycle regulation, cytoskeletal organization and apopt...

Claims

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