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Pleiotropic fullerene-vitamins-water-soluble macromolecular ternary complex and preparation method thereof

A technology of vitamin complex and ternary complex, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, carbon active ingredients, etc., can solve the problems of limited preparation methods, no technical reports, etc. Eliminates complicated processes, improves solubility, and effects of excellent oxidation resistance

Active Publication Date: 2013-06-26
XIAMEN FUNANO NEW MATERIAL TECH COMPANY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, due to the limitation of preparation methods, there is no technical report in this area

Method used

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  • Pleiotropic fullerene-vitamins-water-soluble macromolecular ternary complex and preparation method thereof
  • Pleiotropic fullerene-vitamins-water-soluble macromolecular ternary complex and preparation method thereof
  • Pleiotropic fullerene-vitamins-water-soluble macromolecular ternary complex and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: 3g polyvinylpyrrolidone (PVP), 136mg vitamin C, 34 mg C 60 After mixing evenly, put it in a ball mill, add zirconia balls or agate balls therein and carry out ball milling and mixing for 20 hours. Then the mixture was dissolved in 200 ml of water, and fully stirred for 4 hours, and then the evenly stirred mixed solution was filtered, and the transparent yellow-brown filtrate of the gained was the water-soluble fullerene / vitamin complex, and the incompletely complexed fullerene could dry recovery. Dried C 60 Weighing about 9mg, it can be calculated that C in the complex 60 The mass percentage is about 0.8%. After removing the solvent in the obtained water-soluble fullerene solution, place it in the freezer of the refrigerator until the sample is fully frozen, and then transfer it to a freeze dryer for low-pressure drying for 2 hours to obtain PVP-C 60 -Vitamin C complex powder, weighing about 3.1g.

[0037] Use the obtained PVP-C 60 -Vitamin C complex po...

Embodiment 2

[0039] Example 2 : 3g polyvinylpyrrolidone (PVP), 250mg vitamin B 2 , 34 mg C 60 After mixing evenly, put it in a ball mill, add zirconia balls or agate balls therein for ball milling and mixing for 24 hours. Then the mixture was dissolved in 250 ml of water, and fully stirred for 4 hours, and then the evenly stirred mixed solution was filtered, and the transparent yellowish-brown filtrate of the gained was the water-soluble fullerene / vitamin complex, and the incomplete fullerene could be dry recovery. Dried C 60 Weighing about 7.8mg, it can be calculated that C in the complex 60 The mass percentage is about 0.82%. After removing the solvent in the obtained water-soluble fullerene solution, place it in the freezer of the refrigerator until the sample is fully frozen, and then transfer it to a freeze dryer for low-pressure drying for 2 hours to obtain PVP-C 60 -Vitamin B2 complex powder, weighing about 3.2g.

[0040] Use the obtained PVP-C 60 - Vitamin B 2 Composite p...

Embodiment 3

[0041] Example 3 : Prepare 4 parts of 3g polyvinylpyrrolidone (PVP) with 34 mg C 60 Add 70, 140, 210, and 250 mg of vitamin C to the mixture, mix it evenly, place it in a ball mill, add zirconia balls or agate balls therein and carry out ball milling and mixing for 24 hours. Subsequently, each mixture was dissolved in 250 ml of water, and fully stirred for 4 hours, and then the uniformly stirred mixed solution was filtered, and the transparent yellowish-brown filtrate obtained was the water-soluble fullerene / vitamin complex, and the incompletely complexed fullerene Dry recycling is possible. In the complex obtained after drying, C 60 The mass percentages are 0.78%, 0.78%, 0.81%, and 0.81%, respectively. After removing the solvent in the obtained water-soluble fullerene solution, place it in the freezer of the refrigerator until the sample is fully frozen, then transfer it to a lyophilizer for low-pressure drying for 2 hours, and obtain a series of PVP-C 60 -Vitamin C comp...

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Abstract

The invention discloses a preparation method of a pleiotropic fullerene-vitamins-water-soluble macromolecular ternary complex. The preparation method comprises the following steps of: forcibly mixing fullerene powder, vitamins and water-soluble molecules; then adequately stirring the mixed material in water; and filtering to obtain a transparent filtrate and evaporating to obtain a water-soluble fullerene / vitamine complex. Based on an antioxidant and antibacterial fullerene-water-soluble macromolecular system already invented, vitamins with antioxidation and anti-cancer activity are further introduced to the fullerene-water-soluble macromolecular system so as to obtain a multifunctional water-soluble complex system with antioxidation, antibacterial property and anti-cancer characteristic. The complex has wide application prospect in the fields of cosmetic, biomedicine and the like.

Description

technical field [0001] The invention discloses a fullerene-vitamin-water-soluble polymer ternary compound and a preparation method thereof, belongs to the technical field of water-soluble fullerene ternary compound according to the International Patent Classification (IPC), and particularly relates to A multifunctional water-soluble fullerene ternary complex with physiological activities such as oxidative activity, antibacterial and anticancer properties. Background technique [0002] Fullerenes were discovered in 1985 by Kroto et al. in the study of laser sputtering graphite in a high vacuum environment. However, the research on its real properties and characterization began in 1990 when Krastchmer invented the synthesis of fullerenes by graphite electrode arc discharge method in a low-pressure helium environment to obtain gram-level C 60 After the product. The unique molecular structure and properties of fullerene make it important in the fields of materials, chemistry, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44A61K47/30A61K47/32A61K9/14A61K8/72A61K8/67A61K8/81A61K8/19A61K8/02A61P39/06A61P35/00A61P31/04A61Q19/08A61J3/02A61K31/197A61K31/375A61K31/4188A61K31/4415A61K31/51A61K31/525A61K31/714A61K31/455A61K31/385
Inventor 朱常锋王春儒蒋礼
Owner XIAMEN FUNANO NEW MATERIAL TECH COMPANY
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