Synthesis of laminine Schiff base mononuclear complex with anticancer activity, and pharmaceutical composition thereof

A technology of lamininic Schiff base and lamininic acid, which is applied in the field of drug synthesis, can solve the problems such as the shortage of money, the inability to meet the diversity of cancers, and the development trend of high incidence.
CN103804399AInactive Publication Date: 2014-05-21QINGDAO UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QINGDAO UNIV
Publication Date
2014-05-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to synthesis of a laminine Schiff base mononuclear complex with anticancer activity, and a pharmaceutical composition thereof. The synthesis method concretely comprises: (1) synthesizing a condensed laminine 2-pyridylaldehyde Schiff base mononuclear complex; (2) synthesizing a laminine phenanthroline copper mononuclear complex; (3) synthesizing a condensed laminine 2-pyridylaldehyde Schiff base phenanthroline copper mononuclear complex; (4) synthesizing a condensed bis-laminine 2-pyridylaldehyde Schiff base copper mononuclear complex; and (5) synthesizing a condensed laminine 2-pyridylaldehyde Schiff base platinum mononuclear complex. By carrying out pharmaceutical analysis research aiming at the compound, the invention provides a synthesis method of the laminine Schiff base mononuclear complex with anticancer activity, and a synthesis method of a pharmaceutical composition thereof, the pharmacological analysis is carried out to prove that the compound has an anticancer active effect, is suitable for use in the anticancer field, and has larger medical and medical values.
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Description

technical field

[0001] The invention relates to the synthesis of a lamininic Schiff base mononuclear complex with anticancer activity and its pharmaceutical composition, belonging to the technical field of pharmaceutical synthesis. Background technique

[0002] Since American chemists first discovered that cis-dichlorodiammine platinum has strong anti-tumor activity in animals in 1969, inorganic metal complexes have become the most attractive for scientific and technological workers in the field of anticancer drugs to find a new class of anticancer drugs. one of the directions. For example, Chinese patent CN1557825A proposes a salicylic acid diamine platinum complex with anticancer activity.

[0003] At present, cisplatin is the first-generation anticancer drug widely used clinically, but it has serious side effects such as water insolubility, nephrotoxicity and nausea and vomiting. The second-generation anticancer drug carboplatin introduces hydrophilic 1,1-cyclobutanedic...

Claims

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