64 results about "Degenerative arthritis" patented technology

The present invention relates to a medical composite biomaterial. More specifically, the present invention relates to a medical composite biomaterial including collagen and a hyaluronic acid derivative. Also, the present invention relates to a cartilage cell treating agent using the biomaterial and stem cells derived from a mammal umbilical cord. The biomaterial does not cause an immune reaction, has superior durability, and the cartilage cell treating agent comprising the biomaterial and the stem cells enables arthroscopic surgery, thereby reducing pain of the patient and effectively treat of degenerative arthritis and cartilage damage.

The present disclosure is directed to methods and compositions for treating osteoarthritis and preventing osteoarthritis, by administering a compound that modulates one or more components in the complement system. In one embodiment, a compound that inhibits a component in the complement system is administered to prevent, delay the progression of, or treat osteoarthritis. In other embodiments, compounds with specific inhibition of a component in a particular pathway in the complement system, such as the alternative, mannose binding lectin, and/or classical pathway, are administered to a subject having osteoarthritis or at risk of developing osteoarthritis.

The invention discloses a health product for keeping joint health and increasing bone density and a preparation method thereof. The health product comprises the following active components: glucosamine, chondroitin sulfate, a calcium agent, a copper agent, a manganese agent and vitamins, wherein the glucosamine is glucosamine sulfate, hydrochloride, phosphate or the mixture; auxiliary materials comprise an excipient, a disintegrant, a lubricant, an adhesive, a wetting agent and a coating pre-mixing agent. The health product contains vitamin D3 which can be used for supplementing mineral matters, such as calcium and the like for human bodies and promoting absorption and have treating and preventing functions for rheumatoid arthritis, degenerative arthritis and damaged joint motion. A tabletprepared by the method has the advantages of good disintegrating performance, quick dissolution and effect taking, optimal proportion of use amount of raw materials and various auxiliary materials, product stability enhancement and high absorption utilization rate.

The invention discloses foot-bath traditional Chinese medicine composition with functions of relaxing tendons and activating collaterals. The foot-bath traditional Chinese medicine composition is prepared from raw medicine materials in parts by weight as follows: 10-15 parts of whole herb of speranskia tuberculata, 10-19 parts of ramulus cinnamomi, 10-15 parts of ramulus mori, 10-15 parts of herba lycopodii, 10-17 parts of radix clematidis, 10-19 parts of radix angelicae sinensis, 8-15 parts of radix salvia miltiorrhizae, 8-15 parts of semen sinapis albae, 10-17 parts of liquidambar formosana Hance, 8-12 parts of folium artemisiae argyi, 5-10 parts of Sichuan pepper and 3-5 parts of herba asari. The foot-bath traditional Chinese medicine composition has obvious curative effect on degenerative arthritis with symptoms of wind-cold-dampness arthralgia, the total effective rate reaches 87.5%, and the composition has significant difference (P is smaller than 0.05) when compared with a control group; further, the improvement effect on pain, pressing pain, swelling and joint movement degree of a patient is obviously better than that of the control group. Besides, the foot-bath traditional Chinese medicine composition has unique curative effect on neck shoulder pain and lumbocrural pain.

The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene therapy as a new treatment method for degenerative arthritis is demonstrated. After transfection of TGF-β cDNA expression vectors into fibroblasts (NIH 3T3-TGF-β1), the cells were injected into rabbit achilles tendon and knee joints with artificially-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. Partially defected cartilage model was made to simulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates that the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen.

The invention discloses application powder for removing toxicity and dredging collaterals. The application powder is prepared from the following raw materials in parts by weight: 15-20 parts ofkusnezoff monkshood root, 14-18 parts ofmonkshood, 12-16 parts ofrhizoma arisasmatis, 10-15 parts of asarum, 8-12 parts of Chinese blister beetle, 10-15 parts of angelica root, 12-16 parts of frankincense, 14-18 parts ofacronychia leaf, 16-22 parts of myrrh, 5-10 parts of hematoxylon, 7-13 parts of water pepper root, 10-15 parts of turmeric, 5-10 parts of cortex erythrinae, 11-17 parts of artemisia anomala, 10-15 parts ofmadder, 5-10 parts of curcuma zedoary, 10-15 parts of luffa stem, 5-10 parts of angelica pubescens, 12-16 parts of safflower, 14-18 parts of red peony root, 17-23 parts of camphor root, 10-15 parts of lindera aggregata, 5-10 parts of paniculate swallowwort root, and 10-15 parts of radix clematidis. The medicinal materials are compatible and have the effects of relaxing tendons and dredging collaterals, warming channel and expelling cold, strengthening tendons and bones, activating blood circulation to remove stasis, diminishing swelling and relieving pain, removing toxicity and stagnation, and the like, is remarkable in effect, quick in response and short in cycle of healing when used for treating rheumatic arthritis, rheumatoid arthritis, degenerative arthritis, ankylosing spondylitis, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, hyperostosis, femoral head necrosis and other bone diseases, does not have toxic or side effect, prevents relapse, and is safe and reliable.

The invention relates to traditional Chinese medicine combination for treating retrogressive arthritis and preparation method thereof, belonging to pharmaceutical technique field. The traditional Chinese medicine combination is prepared by the following raw materials by weight parts: mastic, myrrh, acanthopanax bark, pubescent angelica root, radix gentianae macrophyllae, tetrandra root, cibot rhizome, variegated coralbean bark, Chinese clematis, parasite scurrula, mulberry twigs, pepper, boston ivy, camphor respectively 1-5 parts, borneol 2-5 parts, nux vomica 3-7 parts, sichuan aconite root, cinnamon, Lingxian, earthworm, pangolin, pawpaw, rhizome respectively 3-5 parts, sesame oil 5-10 parts. The preparation method is as follow: (1) crushing, (2) refining oil, (3) spreading.

The invention relates to a traditional Chinese medicine combination for treating retrogressive arthritis and preparation method thereof, belonging to pharmaceutical technique field. The traditional Chinese medicine combination is prepared by the following raw materials by weight parts: kusnezoff mondshood, suchuan aconite root, cinnamon, Chinese clematis, earthworm, pangolin, boston ivy, camphor respectively 3-5 weight parts, bornel 3-5 weight parts, rosin 10-20 weight parts, oleum sesami 10-15 weight parts. The preparation method of the traditional Chinese medicine combination are as follow: (1) crushing: respectively crushing borneol and camphor and sieving through 80 mesh, for being standby; mixing and crushing the other raw materials except rosin and sieving the mixture through 80 mesh, for being standby; (2) oil refining: decocting oleum sesami to be water-droplet shaped when dribbling, adding rosin while stirring the oleum sesami, then adding the other medicine and finally adding borneol and camphor; (3) spreading out: slowly plunging the plaster into cold water and continuously stirring the mixture; drying the plaster in the shade to remove the water, heating plaster to dissolve on water bath, spreading out the dissolved plaster on cloth.

The subject invention is related to a cell-mediated gene therapy treatment for orthopedic disease using a member belonging to the transforming growth factor-β (TGF-β) superfamily. TGF-β gene therapy as a new treatment method for degenerative arthritis is demonstrated. After transfection of TGF-β cDNA expression vectors into fibroblasts (NIH 3T3-TGF-β1), the cells were injected into rabbit achilles tendon and knee joints with artificially-made cartilage defects. Intratendinous injections were performed to determine the optimal concentration for in vivo expression. Partially defected cartilage model was made to simulate degenerative arthritis of the knee joint. The partial cartilage defect treated with the cell-mediated gene therapy procedure was covered by newly formed hyaline cartilage which indicates that the cells survived and stimulated matrix formation in this area. Completely denuded cartilage areas were covered by fibrous collagen.

The invention relates to a bionic synovial fluid and a preparation method thereof. Carboxymethyl chitosan is taken as the main raw material of the bionic synovial fluid. Carboxymethyl chitosan with different crosslinking degrees and non-crosslinked carboxymethyl chitosan are mixed by a physical method to prepare the bionic synovial fluid. The molecular weight of the carboxymethyl chitosan is in a range of 20-2000 KDa, preferably 100-800 KDa. The degree of acetylation is in a range of 60-99%, preferably 80-95%. The substitution degree of carboxymethyl is in a range of 0.5-2.0. The visco-elasticity and fluidity indexes of the bionic synovial fluid all meet the standards of normal synovial fluid. The bionic synovial fluid can be used as a visco-elasticity supplementing agent, when the synovial fluid is deficient or the visco-elasticity degrades caused by degenerative arthritis or traumatic arthritis; and is capable of effectively slowing down the process of degenerative arthritis or traumatic arthritis and relieving pains. The bionic synovial fluid has a quick effect after intra-articular injection; the curative effect can last for a long term, and the arthritis can be relieved after single injection.

The invention provides novel application of Atractylodes macrocephala essential oil in the field of pharmacy and particularly relates to application of Atractylodes macrocephala essential oil in the preparation of drugs for treating degenerative arthritis. Atractylodes macrocephala essential oil is efficient in improving physiochemical properties of synovial fluid and improving the symptoms of a patient, such as pain and swelling. The Atractylodes macrocephala essential oil is efficient in treating degenerative arthritis, such as slipped disc, foraminal stenosis, meniscal injury, and hyperostosis. The Atractylodes macrocephala essential oil is convenient to prepare and use, is convenient for a patient to use, and has low toxic and side effects.

The invention belongs to the field of medicines, and concretely relates to a medicine prescription for degenerative arthritis and osteoporosis and a tablet preparation method thereof. The medicine prescription for degenerative arthritis and osteoporosis comprises the following compositions: chondroitin sulfate, glucosamine sulfate, calcium carbonate, calcium hydrogenphosphate, vitamin C, vitamin D3 and casein phosphopeptide. The beneficial effects comprise that the prescription is capable of scientifically solving casein phosphopeptides of the old, and is free of side effect in the usage process, is suitable for long-term usage and stable in curative effect. Also, the table preparation method for the prescription possesses the advantages of high production efficiency, low production cost, stable product quality and the like.

The present invention relates to a polymeric micelle including a kartogenin derivative, a hyaluronic acid hydrogel including the same, a method for producing the same, and a use thereof, and the polymeric micelle and the hyaluronic acid derivative hydrogel including the polymeric micelle slowly release kartogenin, and thus may be usefully used for the purpose of preventing or treating various cartilage disorder-related diseases such as degenerative arthritis because an effect of regenerating chondrocytes while protecting chondrocytes is excellent.

Disclosed is a composition for promoting a production of hyaluronic acid containing at least one of kaempferol and quercetin. Kaempferol and quercetin of the invention increase an expression of a hyaluronic acid synthase (HAS) gene existing in a skin cell line of human epidermis, thereby promoting a production of hyaluronic acid in the human cell. Accordingly, the composition containing at least one of kaempferol and quercetin according to the invention can be usefully used as a cosmetic composition for increasing skin elasticity and preventing skin dryness or aging, or a pharmaceutical composition for treating or preventing a degenerative arthritis.

The invention provides a traditional Chinese medicine preparation with effects of eliminating swelling and reliving pain and activating blood and removing stasis. The traditional Chinese medicine preparation comprises the following traditional Chinese medicine preparation formulae: 12g of notopterygium roots, 12g of radix angelicae tuhuo, 10g of carthamus tinctorius, 15g of akebiaquinata, 10g of lycopodium clavatum, 15g of rhizoma corydalis, 10g of radix angelicae, 6g of asarum, 10g of rhizoma sparganii and 10g of curcuma zedoary. A making method comprises the following steps: preparing materials; cleaning, and crushing; making medicine bags; soaking with cold water; carrying out primary decoction; carrying out secondary decoction; mixing decoctions; smashing medicine dregs; mixing, and boiling; molding the traditional Chinese medicine preparation. The traditional Chinese medicine preparation with effects of eliminating swelling and reliving pain and activating blood and removing stasis, which is provided by the invention, has the effects of eliminating swelling and reliving pain and activating blood and removing stasis for swelling pain and hydrarthrosis caused by orthopedic diseases such as acute gouty arthritis, acute sprain, scapulohumeral periarthritis degenerative arthritis, tenosynovitis and synovitis.

The invention discloses novel hyaluronic acid flowing gel and a preparation method and application thereof. The preparation method comprises the following steps of preparing acidic frozen and unfrozenhyaluronic acid gel; preparing neutral frozen and unfrozen hyaluronic acid gel; and performing freeze drying and breaking treatment on the neutral frozen and unfrozen hyaluronic acid gel and preparing the hyaluronic acid flowing gel. The prepared hyaluronic acid flowing gel is physical gel, is free from a cross-linking agent, cannot cause chemical substance residues, and cannot cause potential cytotoxicity. The novel hyaluronic acid flowing gel has the advantages of being favorable in biocompatibility, high in degradability resistance, injectable and the like, and can be applied to degenerative arthritis treatment, postoperative anti-adhesion, wound healing, cosmetology stuffing and the like.

The invention provides a health care product for enhancing bone density and improving immunity and a preparation method of the health care product. The health care product has the functions of enhancing bone density, repairing cartilage tissues and improving immunity. Mainly based on tonifying the liver and kidney and assisting the functions of dispelling wind and eliminating dampness and promoting blood circulation to remove blood stasis, the product further improves the adverse environment of damaged regions of rheumatoid bone diseases, so that treatment on both symptoms and root causes is realized. The health care product has the functions of treating cervical spondylosis, lumbar spondylosis, degenerative arthritis, rheumatic arthritis or rheumatoid arthritis and the like. By adopting decoction pieces corn cervi pantotrichum, achyranthes bidentata, prepared rehmannia roots, roots of kudzu vines, herba epimedii and the like which are combined, the product hits the pathogenesis of deficiency of the kidney, insufficiency of the spleen and blood stasis of osteoporosis and that of deficiency of kidney storing congenital vital essence and spleen governing water valley of immunocompromised people, the full formula has the functions of tonifying liver and kidney, tonifying spleen, enriching blood, promoting blood circulation to remove blood stasis, strengthening tendons and bones and strengthening body resistance and eliminating evil, achieves the health care functions of enhancing the bone density and improving the immunity, and has remarkable effects on various bone diseases.

The invention relates to an agkistrodon-containing preparation for gouty arthritis treatment and belongs to the technical field of Chinese herbal medicine preparations. The preparation is prepared from three Chinese herbal medicines including agkistrodon, coix seeds and pseudobulbus cremastrae seu pleiones. The preparation is based on research and treatment principles of traditional Chinese medicine for pathogenesis of gouty arthritis and refers to scientific achievements of modern traditional Chinese medicine theories for Chinese herbal medicine treatment of gouty arthritis, and agkistrodon is adopted to dispel wind and remove obstruction in the meridians and is supplemented with the coix seeds for excreting dampness, removing arthralgia, eliminating toxic materials and removing stasis; the pseudobulbus cremastrae seu pleiones has effects of clearing away heat and toxic materials, reducing phlegm and resolving masses; the three Chinese herbal medicines are compatible, supplement each other, and has functions of dispelling wind, removing obstruction in the meridians, excreting dampness, removing arthralgia, eliminating toxic materials and removing stasis. The prescription is rigorous, accords with traditional Chinese medicine theories and new knowledge of the modern medicine for gouty arthritis and is free of toxic and side effects; the preparation has remarkable curative effects on redness and swelling of joints, heat pain, stiffness, flexion-extension inconvenience due to gouty arthritis as well as inhibition for uric acid formation and further has obvious curative effects on rheumatic fever, rheumatoid arthritis, ankylosing spondylitis and degenerative arthritis.

The invention discloses an externally applied traditional Chinese medicine composition for treating degenerative arthritis. The externally applied traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal raw materials: herba ephedrae, notopterygium incisum, cacumen tamaricis, wampee seeds, mosla scabra, herba achyranthis asperae, rhizoma picrorhizae, melicope pteleifolia, radix ilicis pubescentis, wikstroemia indica, semen zanthoxyli, fructus piperis, herba agastaches, adiantum capillus-veneris, excrementum bombycis, semen lepidii, thallus laminariae, aspongopus, herba lycopi, flos impatientis, radix glycyrrhizae, mylabris preparata and gryllotalpa africana preparata. The externally applied traditional Chinese medicine composition is significant in curative effect during the treatment of degenerative arthritis, quick in curing and significant in effect, and has an effective rate of 100% and a cure rate of 94%.

The invention discloses an oral liquid medicament for tonifying kidney and strengthening bone and a method for producing the same. The method comprises the following steps: adding water into barbary wolfberry fruit, astragalus, szechwon tangshen root, glossy privet fruit, Himalayan teasel root, fortune's drynaria rhizome, flowery knotweed stem, spina date seed, shinyleaf pricklyash root, Chinese angelica, radix aconite preparata and liquoric root for decoction, merging decoction, filtering the decoction, concentrating the decoction under a reduced pressure into thick paste, cooling the thick paste, adding ethanol for precipitation twice, recycling the ethanol under the reduced pressure, rationally adding distilled water, uniformly stirring the paste for cold storage, filtering the stirred paste, rationally adding gooey and an aseptic for boiling, and filtering, encapsulating and sterilizing the solution. The oral liquid medicament has relatively better healing effect on fracture in convalescence, soft tissue injury, patients in recovery after operations, lumbar and leg pain, bone loss, degenerative arthritis and liver and kidney deficiency type lumbar intervertebral disc protrusion, satisfactory clinical effect, good taste and convenient administration, does not cause cutaneous anaphylaxis and other untoward reactions, and has the characteristics of simple production process, stable product quality and low cost.

The invention discloses an application of FGF-2 derived polypeptide to preparation of medicines for promoting cartilage repairing and/or treating degenerative arthritis. The FGF-2 derived polypeptideis polypeptide as shown in SEQID NO:1 or polypeptide as shown in SEQID NO:2. Peptide PDG6 and KED7 are from FGF-2, cartilage can be notably promoted to regenerate, and the FGF-2 derived polypeptide has favorable treatment effects on degenerative arthritis, besides, is easy to synthetize and low in immunogenicity, and has wide application prospects in treatment of cartilage injury and degenerativearthritis.