Bionic synovial fluid and preparation method thereof
A bionic joint and synovial fluid technology, applied in the field of bionic joint synovial fluid and its preparation, to achieve the effects of slowing down the process, good compatibility, and relieving pain
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Embodiment 1
[0026] BDDE was selected as the cross-linking agent, and the cross-linking degrees were 2%, 5%, 10%, and 20% respectively. ), the mass concentration of carboxymethyl chitosan in the cross-linked gel was 30 mg / mL, and the pH value was 7.2. Prepare non-crosslinked carboxymethyl chitosan solution with a mass concentration of 20 mg / mL and a pH value of 7.2. Among them, non-cross-linked carboxymethyl chitosan, 2% cross-linked carboxymethyl chitosan, 5% cross-linked carboxymethyl chitosan, 10% cross-linked carboxymethyl chitosan, 20% cross-linked carboxymethyl chitosan The proportions of methyl chitosan are: 40%, 20%, 20%, 15%, 5%. After mixing the cross-linked carboxymethyl chitosan gel and the non-cross-linked carboxymethyl chitosan solution, the T 65 digital ULTRA-TURRAX® Package disperser from IKA Company was used to disperse for 30 min under the condition of 500 r / min , repeat the dispersion 5 times. After pulverization, the gel was taken out, kept at 121°C for 15 minutes for ...
Embodiment 2
[0028] Glutaraldehyde was used as the cross-linking agent, and the cross-linking degrees were 2%, 8%, and 15%, respectively. , the mass concentration of carboxymethyl chitosan in the cross-linked gel was 35 mg / mL, and the pH value was 7.2. Prepare non-crosslinked carboxymethyl chitosan solution with a mass concentration of 25 mg / mL and a pH value of 7.2. Among them, the proportions of non-cross-linked carboxymethyl chitosan, 2% cross-linked carboxymethyl chitosan, 8% cross-linked carboxymethyl chitosan, and 15% cross-linked carboxymethyl chitosan are respectively: 50 %, 30%, 18%, 2%. After mixing the cross-linked carboxymethyl chitosan gel with the non-cross-linked carboxymethyl chitosan solution, the T 65 digital ULTRA-TURRAX® Package disperser from IKA Company was used to disperse for 35 min under the condition of 800 r / min. Repeat the dispersal 8 times. After the pulverization was completed, the gel was taken out, kept at 115°C for 30 minutes for high temperature and hig...
Embodiment 3
[0030] Epichlorohydrin was selected as the cross-linking agent, and the cross-linking degrees were 2%, 5%, 8%, 12%, 15% and other five cross-linked carboxymethyl chitosan gels (molecular weight 200 KDa, deacetylation degree 90%, substitution degree 1.2), the mass concentration of carboxymethyl chitosan in the cross-linked gel was 30 mg / mL, and the pH value was 7.2. Prepare non-crosslinked carboxymethyl chitosan solution with a mass concentration of 20 mg / mL and a pH value of 7.2. Among them, non-cross-linked carboxymethyl chitosan, 2% cross-linked carboxymethyl chitosan, 5% cross-linked carboxymethyl chitosan, 8% cross-linked carboxymethyl chitosan, 12% cross-linked carboxymethyl chitosan The proportions of methyl chitosan and 15% cross-linked carboxymethyl chitosan are: 40%, 20%, 15%, 10%, 10%, and 5%, respectively. After mixing the cross-linked carboxymethyl chitosan gel and the non-cross-linked carboxymethyl chitosan solution, the T 65digital ULTRA-TURRAX® Package disperse...
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