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Bionic joint synovial fluid and its preparation method

A bionic joint and synovial fluid technology, applied in the field of bionic joint synovial fluid and its preparation, to achieve good compatibility, slow down the process, and relieve pain

Active Publication Date: 2020-09-08
IMEIK TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the current injection of carboxymethyl chitosan to treat arthritis still requires multiple injections to ensure the therapeutic effect. This is because the retention time of carboxymethyl chitosan in the body still cannot meet the efficacy of a single injection. If chitosan has a long-term therapeutic effect in the joints of arthritis, carboxymethyl chitosan must be stabilized to prolong the retention time of carboxymethyl chitosan in the body, and it is also necessary to imitate normal joints. The viscoelasticity and fluidity indexes of synovial fluid, and the bionic joint synovial fluid was prepared

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] BDDE was selected as the cross-linking agent, and the cross-linking degrees were 2%, 5%, 10%, and 20% respectively. ), the mass concentration of carboxymethyl chitosan in the cross-linked gel was 30mg / mL, and the pH value was 7.2. Prepare non-crosslinked carboxymethyl chitosan solution with a mass concentration of 20 mg / mL and a pH value of 7.2. Among them, non-cross-linked carboxymethyl chitosan, 2% cross-linked carboxymethyl chitosan, 5% cross-linked carboxymethyl chitosan, 10% cross-linked carboxymethyl chitosan, 20% cross-linked carboxymethyl chitosan The proportions of methyl chitosan are: 40%, 20%, 20%, 15%, 5%. After mixing the cross-linked carboxymethyl chitosan gel and the non-cross-linked carboxymethyl chitosan solution, the T 65 digital ULTRA-TURRAX® Package disperser from IKA Company was used to disperse for 30 min under the condition of 500 r / min , repeat the dispersion 5 times. After pulverization, the gel was taken out, kept at 121°C for 15 minutes for h...

Embodiment 2

[0028] Glutaraldehyde was used as the cross-linking agent, and the cross-linking degrees were 2%, 8%, and 15%, respectively. , the mass concentration of carboxymethyl chitosan in the cross-linked gel was 35 mg / mL, and the pH value was 7.2. Prepare non-crosslinked carboxymethyl chitosan solution with a mass concentration of 25 mg / mL and a pH value of 7.2. Among them, the proportions of non-cross-linked carboxymethyl chitosan, 2% cross-linked carboxymethyl chitosan, 8% cross-linked carboxymethyl chitosan, and 15% cross-linked carboxymethyl chitosan are respectively: 50 %, 30%, 18%, 2%. After mixing the cross-linked carboxymethyl chitosan gel and the non-cross-linked carboxymethyl chitosan solution, the T 65 digital ULTRA-TURRAX® Package disperser from IKA Company was used to disperse for 35 min under the condition of 800 r / min , repeat the dispersion 8 times. After the pulverization was completed, the gel was taken out, kept at 115°C for 30 minutes for high temperature and hi...

Embodiment 3

[0030] Epichlorohydrin was selected as the cross-linking agent, and the cross-linking degrees were 2%, 5%, 8%, 12%, 15% and other five cross-linked carboxymethyl chitosan gels (molecular weight 200 KDa, deacetylation degree 90%, substitution degree 1.2), the mass concentration of carboxymethyl chitosan in the cross-linked gel was 30 mg / mL, and the pH value was 7.2. Prepare non-crosslinked carboxymethyl chitosan solution with a mass concentration of 20 mg / mL and a pH value of 7.2. Among them, non-cross-linked carboxymethyl chitosan, 2% cross-linked carboxymethyl chitosan, 5% cross-linked carboxymethyl chitosan, 8% cross-linked carboxymethyl chitosan, 12% cross-linked carboxymethyl chitosan The proportions of methyl chitosan and 15% cross-linked carboxymethyl chitosan are: 40%, 20%, 15%, 10%, 10%, and 5%, respectively. After mixing the cross-linked carboxymethyl chitosan gel and the non-cross-linked carboxymethyl chitosan solution, the T 65digital ULTRA-TURRAX® Package disperse...

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PUM

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Abstract

The invention relates to a bionic synovial fluid and a preparation method thereof. Carboxymethyl chitosan is taken as the main raw material of the bionic synovial fluid. Carboxymethyl chitosan with different crosslinking degrees and non-crosslinked carboxymethyl chitosan are mixed by a physical method to prepare the bionic synovial fluid. The molecular weight of the carboxymethyl chitosan is in a range of 20-2000 KDa, preferably 100-800 KDa. The degree of acetylation is in a range of 60-99%, preferably 80-95%. The substitution degree of carboxymethyl is in a range of 0.5-2.0. The visco-elasticity and fluidity indexes of the bionic synovial fluid all meet the standards of normal synovial fluid. The bionic synovial fluid can be used as a visco-elasticity supplementing agent, when the synovial fluid is deficient or the visco-elasticity degrades caused by degenerative arthritis or traumatic arthritis; and is capable of effectively slowing down the process of degenerative arthritis or traumatic arthritis and relieving pains. The bionic synovial fluid has a quick effect after intra-articular injection; the curative effect can last for a long term, and the arthritis can be relieved after single injection.

Description

technical field [0001] The invention relates to a bionic joint synovial fluid and a preparation method thereof. Using this method, bionic joint synovial fluid with viscoelasticity and fluidity index reaching normal joint synovial fluid can be formed, which can be used as a viscoelastic supplement when degenerative or traumatic arthritis causes joint synovial fluid loss or viscoelasticity decrease, It can effectively slow down the progression of degenerative or traumatic arthritic lesions and relieve pain. Background technique [0002] Joint synovial fluid is secreted by the synovial membrane of the joint synovial bursa and tendon sheath. It contains a transparent viscous lubricating fluid similar to mucin. It has a lubricating effect and is a secretion of human organs and tissues. The effect of toxins. The main components of synovial fluid are water and a large number of nutrients, which can not only nourish the joints, stomach, brain, marrow and other tissues and organs, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14A61L31/16
CPCA61L31/042A61L31/14A61L31/145A61L31/148A61L31/16A61L2300/402A61L2300/41A61L2400/06C08L5/08
Inventor 简军李睿智
Owner IMEIK TECH DEV CO LTD
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