Aerosol with efficacies of diminishing inflammation and easing pain and preparation method of aerosol

An anti-inflammatory, analgesic, aerosol technology, applied in the field of medicine, can solve problems such as gastrointestinal adverse reactions, liver first-pass effect, difficulty in swallowing, etc., to avoid gastrointestinal stimulation and liver first-pass effect, transdermal absorption Good, high local concentration effect

Inactive Publication Date: 2017-04-19
广东同德药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But these different dosage forms also exist various deficiencies when bringing into play its effect.
For example, oral non-steroidal analgesic anti-inflammatory drugs cause adverse reactions in the gastrointestinal tract, liver first-pass effect, and there are also problems with bad smell and difficulty in swallowing

Method used

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  • Aerosol with efficacies of diminishing inflammation and easing pain and preparation method of aerosol
  • Aerosol with efficacies of diminishing inflammation and easing pain and preparation method of aerosol
  • Aerosol with efficacies of diminishing inflammation and easing pain and preparation method of aerosol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] An anti-inflammatory and analgesic aerosol, the aerosol is composed of a gas phase and a liquid phase, the gas phase is a propellant, and the liquid phase is composed of the following raw materials in parts by mass:

[0036]

[0037] Wherein, the mass ratio of the gas phase and the liquid phase is 1:6, and the propellant is isobutane.

[0038] The preparation method of the above-mentioned anti-inflammatory and analgesic aerosol comprises the following steps:

[0039] S1: Crush diclofenac sodium into fine powder, add it into ethanol, stir and mix well, and set aside;

[0040] S2: Mix laurocapram, propylene glycol, ethanol and polyethylene glycol evenly, and set aside;

[0041] S3: Mix the mixed solution obtained from S1 and S2 evenly, and stir at high speed until the mixed solution is a micron-sized microemulsion solution;

[0042] S4: Inject the micron-sized microemulsion solution obtained in S3 into the filling container, seal it, inject propellant, and press the ...

Embodiment 2

[0045] An anti-inflammatory and analgesic aerosol, the aerosol is composed of a gas phase and a liquid phase, the gas phase is a propellant, and the liquid phase is composed of the following raw materials in parts by mass:

[0046]

[0047] Wherein, the mass ratio of the gas phase and the liquid phase is 1:5, and the propellant is isobutane.

[0048] The preparation method of the above-mentioned anti-inflammatory and analgesic aerosol comprises the following steps:

[0049] S1: Crush diclofenac sodium into fine powder, add it into ethanol, stir and mix well, and set aside;

[0050] S2: Mix laurocapram, propylene glycol, ethanol and polyethylene glycol evenly, and set aside;

[0051] S3: Mix the mixed solution obtained from S1 and S2 evenly, and stir at high speed until the mixed solution is a micron-sized microemulsion solution;

[0052] S4: Inject the micron-sized microemulsion solution obtained in S3 into the filling container, seal it, inject propellant, and press the ...

Embodiment 3

[0055] An anti-inflammatory and analgesic aerosol, the aerosol is composed of a gas phase and a liquid phase, the gas phase is a propellant, and the liquid phase is composed of the following raw materials in parts by mass:

[0056]

[0057] Wherein, the mass ratio of the gas phase and the liquid phase is 1:4, and the propellant is isobutane.

[0058] The preparation method of the above-mentioned anti-inflammatory and analgesic aerosol comprises the following steps:

[0059] S1: Crush diclofenac sodium into fine powder, add it into ethanol, stir and mix well, and set aside;

[0060] S2: Mix laurocapram, propylene glycol, ethanol and polyethylene glycol evenly, and set aside;

[0061] S3: Mix the mixed solution obtained from S1 and S2 evenly, and stir at high speed until the mixed solution is a micron-sized microemulsion solution;

[0062] S4: Inject the micron-sized microemulsion solution obtained in S3 into the filling container, seal it, inject propellant, and press the ...

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Abstract

The invention relates to an aerosol with the efficacies of diminishing inflammation and easing pain and a preparation method of the aerosol. The aerosol is composed of a gas phase and a liquid phase, wherein the gas phase is a propellant; the liquid phase is prepared from the following raw materials in parts by weight: 10-20 parts of diclofenac sodium, 5-10 parts of laurocapram, 20-50 parts of propylene glycol, 30-40 parts of alcohol, and 10-20 parts of polyethylene glycol; the weight ratio of the gas phase to the liquid phase is 1: (2-6); the propellant is one or more of dimethylmethane and butane mixture, iso-butane, tetrafluoroethane, heptafluoropropane and dimethyl ether. The aerosol with the efficacies of diminishing inflammation and easing pain provided by the invention has the efficacies of diminishing inflammation and relieving swelling, resolving heat and easing pain, and the like; the test of many clinical research institutions proves that the aerosol provided by the invention has very good treatment effects for sport injuries or the acute attack of acute arthritis such as gout and degenerative arthritis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to an anti-inflammatory and analgesic aerosol and a preparation method thereof. Background technique [0002] Diclofenac sodium is a new type of non-steroidal anti-inflammatory analgesic, which has good antipyretic and analgesic effects. Pain and fever of various causes. [0003] Diclofenac sodium anti-inflammatory and analgesic drugs have the advantages of good curative effect, small side effects, and no accumulation in long-term use among similar drugs. At present, there are many dosage forms of diclofenac sodium on the market, and they have better therapeutic effects. For example, diclofenac sodium oral tablet has better anti-inflammatory and analgesic effects, and diclofenac sodium gel has anti-inflammatory, anti-rheumatic, pain-relieving and antipyretic effects. effect. But these different dosage forms also have various weak points when bringing into play its effect. For example, or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K47/22A61K31/196A61P29/00
CPCA61K9/12A61K9/0014A61K31/196A61K47/22
Inventor 夏敏林文辉廖小丹肖海文程秋慧黄洁瑕
Owner 广东同德药业有限公司
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