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Pharmaceutical composition for treating liver diseases and preparation method thereof

A technology of composition and medicine, which is applied in the field of pharmaceutical composition for treating liver diseases and its preparation, can solve the problems of increasing the amount of glycyrrhetinic acid, increasing the concentration of glycyrrhizic acid, and accelerating the elimination of glycyrrhizic acid, etc. low cost effect

Inactive Publication Date: 2011-05-25
WUHAN KANGLE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Xiang Qi, etc. from the Pharmacy Teaching and Research Office of Shenyang Pharmaceutical University also found through research that the relative bioavailability of glycyrrhetinic acid in the Shaoyao Gancao Decoction group to the single licorice group was 15.7. Elevated and accelerated elimination of glycyrrhizic acid, resulting in increased conversion of glycyrrhizic acid to glycyrrhetinic acid

Method used

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  • Pharmaceutical composition for treating liver diseases and preparation method thereof
  • Pharmaceutical composition for treating liver diseases and preparation method thereof
  • Pharmaceutical composition for treating liver diseases and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Example 1 Granule 1 (sugar type)

[0087] Take 28kg of licorice and 37kg of white peony, wash, slice, dry, add 6 times the amount of water to decoct 3 times, 3 hours each time. Filter and combine the extracts. Concentrate to about 80L, add 3 times the volume of ethanol, stir evenly, adjust the ethanol concentration to 65% by volume, let stand for 48h, and filter to obtain the first filtrate; add 3 times the volume of 18% ethanol to the precipitate and stir well. Let stand for 12h, filter, and get the second filtrate. The two filtrates were combined and concentrated under reduced pressure to 13.1 kg of 1.28 (60°C) clear paste.

[0088] Crush the sucrose, pass a 100-mesh sieve, weigh 90kg, place it in a wet granulator, turn on and stir for 2 minutes, add the above-mentioned clear paste while stirring, and stir for 5 minutes to make a uniform soft material. Place the soft material in a swing type On the pelletizer, a 14-mesh nylon screen is used to make wet pellets. The wet...

Embodiment 2

[0094] Example 2 Granules 2 (sugar type)

[0095] Take 28 kg of licorice and 42 kg of white peony, wash, slice, and dry. The first time is 6 times the weight of the medicinal material, and the second time is 4 times the weight of the medicinal material. Both times are decocted for 1.5 hours. Filter and combine the extracts. Concentrate to about 70L, add 3 times the volume of ethanol, stir evenly, adjust the ethanol concentration to 67% by volume, let stand for 48h, and filter to obtain the first filtrate; add 3 times the amount of 18% ethanol for the precipitation, stir well, Let stand for 12h, filter, and get the second filtrate. The two filtrates were combined and concentrated under reduced pressure to 13.6 kg of 1.28 (60°C) clear paste.

[0096] Crush the sucrose, pass through a 100-mesh sieve, weigh 95kg, place it in a wet granulator, turn on and stir for 2 minutes, add the above clear paste while stirring, and stir for 5 minutes to make a uniform soft material. Place the sof...

Embodiment 3

[0100] Example 3 Granules 3 (with sugar type)

[0101] Take 28kg of licorice and 47kg of white peony, wash, slice, dry, add 8 times the amount of water to decoc 2 times, 2h each time. Filter and combine the extracts. Concentrate to about 70L, add 3 times the volume of ethanol, stir evenly, adjust the ethanol concentration to 67% by volume, let stand for 48h, and filter to obtain the first filtrate; add 3 times the amount of 18% ethanol for the precipitation, stir well, Let stand for 12h, filter, and get the second filtrate. The two filtrates were combined and concentrated under reduced pressure to 16.1 kg of 1.28 (60°C) clear cream.

[0102] Crush the sucrose, pass through a 100-mesh sieve, weigh 95kg, place it in a wet granulator, turn on and stir for 2 minutes, add the above clear paste while stirring, and stir for 5 minutes to make a uniform soft material. Place the soft material in a rocking type On the pelletizer, a 14-mesh nylon screen is used to make wet pellets. The wet...

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Abstract

The invention discloses a pharmaceutical composition for treating liver diseases, which is prepared by the following active ingredients according to the mixture ratio by weight: liquoric root: white paeony root is equal to 1: 1.1-1: 1.9. In addition, the invention further discloses a preparation method, a use and a quality detection method of the pharmaceutical composition. Clinical observation proves that the pharmaceutical composition can effectively reduce aminotransferase, stop liver area pain and effectively restore liver functions, so that the pharmaceutical composition can be used for treating acute and chronic viral hepatitis and early cirrhosis, and also has better efficacy for patients with advanced schistosomiasis. The medicament with the formula has no toxicity or side effects and can meet the period treatment demand of the patients with the acute and chronic viral hepatitis.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and more specifically, relates to a pharmaceutical composition for treating liver disease and a preparation method, application and quality control method thereof. The pharmaceutical composition comprises white peony root and licorice. Background technique [0002] According to statistics from the World Health Organization (WHO), there are more than 2 billion hepatitis B virus carriers worldwide. Currently, there are nearly 400 million hepatitis B patients worldwide, which is 10 times the number of people infected with AIDS. Every year, 10 to 30 million people worldwide are infected with hepatitis B virus, and 1 million patients die from hepatitis B and its complications, that is, two patients die from hepatitis B and its complications every minute. Hepatitis B has become the most serious liver infectious disease in the world, and it can cause liver failure, cirrhosis or liver ca...

Claims

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Application Information

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IPC IPC(8): A61K36/71G01N30/36G01N30/90A61P1/16A61K31/704A61K31/7048
CPCY02A50/30
Inventor 钱丽娜张继良江书银
Owner WUHAN KANGLE PHARMA
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