Chinese medicine microemulsion preparation with enhanced percutaneous permeability and preparation method thereof
A technology of permeability and emulsion preparation, which is applied in the field of high percutaneous permeability traditional Chinese medicine microemulsion preparation and its preparation, and achieves the effects of good tolerance, reduced administration frequency and high percutaneous permeability
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Embodiment 1
[0018] Take 0.3g of ethylhexyl isononanoate, add 0.2g of oleic acid, ultrasonically dissolve until it becomes a transparent liquid, add 0.2g of Tween-80, 0.8g of caprylic / capric macrogol glyceride, and 0.5g of absolute ethanol Ultrasonic dissolution, to a light yellow translucent liquid, to obtain I, take 0.05g of triptolide extract, add I, ultrasonic dissolution. Add 7.95g of water and mix well, that is.
Embodiment 2
[0020] Take 0.32g of ethylhexyl isononanoate, add 0.32g of oleic acid, ultrasonically dissolve until it becomes a transparent liquid, add Tween-800.34g, caprylic / capric macrogol glyceride 1.37g, absolute ethanol 0.85g Ultrasonic dissolution, to a light yellow translucent liquid, to obtain I, get 0.15g of triptolide extract, add I, ultrasonic dissolution. Add 6.65g of water and mix well, that is.
Embodiment 3
[0022] Take 0.4g of ethylhexyl isononanoate, add 0.4g of oleic acid, ultrasonically dissolve until it becomes a transparent liquid, add Tween-800.36g, caprylic / capric macrogol glyceride 1.44g, absolute ethanol 0.6g Ultrasonic dissolution, until light yellow translucent liquid, to obtain I, take tripteride alcohol extract 0.1g, add I, ultrasonic dissolution. Add 6.7g of water and mix well, that is.
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