Chinese medicine microemulsion preparation with enhanced percutaneous permeability and preparation method thereof

A technology of permeability and emulsion preparation, which is applied in the field of high percutaneous permeability traditional Chinese medicine microemulsion preparation and its preparation, and achieves the effects of good tolerance, reduced administration frequency and high percutaneous permeability

Inactive Publication Date: 2009-10-28
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of microemulsion as a transdermal drug delivery carrier has great potential and broad prospects, but in the field of traditional Chinese medicine, there are few studies at home and abroad, and there is no product of microemulsion external preparation of traditional Chinese medicine. Promising and meaningful work

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Take 0.3g of ethylhexyl isononanoate, add 0.2g of oleic acid, ultrasonically dissolve until it becomes a transparent liquid, add 0.2g of Tween-80, 0.8g of caprylic / capric macrogol glyceride, and 0.5g of absolute ethanol Ultrasonic dissolution, to a light yellow translucent liquid, to obtain I, take 0.05g of triptolide extract, add I, ultrasonic dissolution. Add 7.95g of water and mix well, that is.

Embodiment 2

[0020] Take 0.32g of ethylhexyl isononanoate, add 0.32g of oleic acid, ultrasonically dissolve until it becomes a transparent liquid, add Tween-800.34g, caprylic / capric macrogol glyceride 1.37g, absolute ethanol 0.85g Ultrasonic dissolution, to a light yellow translucent liquid, to obtain I, get 0.15g of triptolide extract, add I, ultrasonic dissolution. Add 6.65g of water and mix well, that is.

Embodiment 3

[0022] Take 0.4g of ethylhexyl isononanoate, add 0.4g of oleic acid, ultrasonically dissolve until it becomes a transparent liquid, add Tween-800.36g, caprylic / capric macrogol glyceride 1.44g, absolute ethanol 0.6g Ultrasonic dissolution, until light yellow translucent liquid, to obtain I, take tripteride alcohol extract 0.1g, add I, ultrasonic dissolution. Add 6.7g of water and mix well, that is.

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PUM

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Abstract

The invention provides a Chinese medicine microemulsion preparation with enhanced percutaneous permeability and preparation method thereof, which is characterized in that: the preparation contains the following raw materials in weight ratio: tripterygium alcohol extract 0.1-1.5, mixed oil phase 1-10, mixed surfactant 10-30, cosurfactant 0.1-10 and double distilled water 60-85. The preparation provided by the invention has the advantages of: good percutaneous permeability and good inclusiveness, which cause the Chinese medicine complicated components easy to be molded; thereby avoiding stimulation of oral preparation to gastrointestinal tract and first-pass effect, generating lasting and constant blood concentration, reducing administration frequency, reducing pharmaceutical toxic and side effects. Body surface administration can directly reach focus for resolving patient complaint more quickly, because the medicine can be used conveniently, and is easy to control, paint and clean; the tripterygium microemulsion preparation provided by the invention has a percutaneous permeation rate which is 6.15 times of that of tripterygium ointment with identical drug loading, and conforms to zero level release equation, and reflects high-efficient and constant-speed release characteristics.

Description

technical field [0001] The invention relates to a traditional Chinese medicine microemulsion preparation, in particular to a traditional Chinese medicine microemulsion preparation with high transdermal permeability and a preparation method thereof. Background technique [0002] Microemulsion is composed of oil, surfactant, co-surfactant and hydrophilic phase. It has the characteristics of transparent appearance, thermodynamic stability, isotropy, and the droplet size of the dispersed phase is less than 100nm. As a new type of drug delivery system, microemulsion has the advantages of good stability, strong solubility, low viscosity, simple preparation, easy industrialization, and sterilization by filtration. It has been widely used in the field of pharmacy for the past 20 years. Research on multiple routes of administration such as skin, oral, injection, and mucosal administration. Microemulsions are more and more widely used in transdermal drug delivery systems. Compared wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61K9/107A61P29/00A61P37/06A61P35/00A61K47/14A61K47/34A61K47/10A61K47/26
Inventor 朱卫丰陈丽华管咏梅张霄潇乐西薇刘红宁赵益杨明
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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