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Triamcinolone acetonide econazole cream

A technology of deconazole cream and econazole nitrate, which is applied in the field of medicine, can solve problems such as insufficient stability, and achieve the effects of easy coating and washing, improved emulsifying ability, and stable quality

Inactive Publication Date: 2008-08-13
刘全胜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] For the existing deficiency of the stability of the current triamcinolone acetonide econazole cream, the purpose of the present invention is to provide a new triamcinolone acetonide econazole cream formula, Add cetyl alcohol or stearyl alcohol to the prescription to solve the shortcoming of poor quality stability of this variety, improve the stability of triamcinolone acetonide econazole cream, and increase the validity period of this variety

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The weight of each component of triamcinolone acetonide econazole cream is shown in Table 1:

[0026] Table 1 The dosage of each component of triamcinolone acetonide econazole cream

[0027] Econazole Nitrate 20.0g

[0028] Triamcinolone Acetonide 2.0g

[0029] Polyoxyethylene-7-stearate 250.0g

[0030] Polyoxyethylene-5-oleate 60.0g

[0031] Benzoic acid 2.0g

[0032] Disodium EDTA 2.0g

[0033] Octadecanol 100.0g

[0034] Butylated hydroxyanisole 0.3g

[0035] Liquid paraffin 200.0g

[0036] Purified water 1370.0g

[0037] (1) Preparation of mixture I: Dissolve disodium ethylenediaminetetraacetic acid and benzoic acid in purified water by weighing the recipe amount, then heat to 80-90°C, keep warm, and use it as the water phase.

[0038] (2) Preparation of mixture II: take stearyl alcohol, polyoxyethylene-7-stearate, polyoxyethylene-5-oleate, liquid paraffin, butylated hydroxyanisole and heat and melt in the recipe amount, as the oil phase.

[0039] (3) Pre...

Embodiment 2

[0046] The weight of each component of triamcinolone acetonide econazole cream is shown in Table 3

[0047] Table 3 Triamcinolone acetonide econazole cream each component weight

[0048] Econazole Nitrate 21.0g

[0049] Triamcinolone Acetonide 2.5g

[0050] Polyoxyethylene-7-stearate 255.0g

[0051] Polyoxyethylene-5-oleate 63.0g

[0052] Potassium sorbate 2.6g

[0053] Sodium sulfite 2.4g

[0054] Cetyl Alcohol 108.0g

[0055] Butylated hydroxyanisole 0.4g

[0056] Liquid paraffin 209.0g

[0057] Purified water 1375.0g

[0058] (1) Preparation of mixture I: Weigh the prescribed amount of sodium sulfite and potassium sorbate and dissolve them in purified water, then heat to 80-90° C., keep warm, and use it as the water phase.

[0059] (2) Preparation of mixture II: take cetyl alcohol, polyoxyethylene-7-stearate, polyoxyethylene-5-oleate, liquid paraffin, butylated hydroxyanisole and heat and melt after weighing the recipe amount, as the oil phase.

[0060] (3) Prepa...

Embodiment 3

[0067] The weight of each component is shown in Table 5

[0068] Table 5 Triamcinolone acetonide econazole cream each component weight

[0069] Econazole Nitrate 19.0g

[0070] Triamcinolone Acetonide 2.2g

[0071] Polyoxyethylene-7-stearate 247.0g

[0072] Polyoxyethylene-5-oleate 62.0g

[0073] Benzoic acid 2.3g

[0074] Sodium sulfite 2.0g

[0075] Cetyl Alcohol 103.0g

[0076] Butylated hydroxyanisole 0.32g

[0077] Liquid paraffin 199.0g

[0078] Purified water 1382.0g

[0079] (1) Preparation of mixture I: Dissolve the prescription amount of sodium sulfite and benzoic acid in purified water, then heat to 80-90° C., keep warm, and use it as the water phase.

[0080] (2) Preparation of mixture II: take cetyl alcohol, polyoxyethylene-7-stearate, polyoxyethylene-5-oleate, liquid paraffin, butylated hydroxyanisole and heat and melt after weighing the recipe amount, as the oil phase.

[0081] (3) Preparation of mixture III: slowly add mixture II to mixture I, stir whi...

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PUM

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Abstract

The invention discloses a triamcinolone acetonide and econazole nitrate cream which contains econazole nitrate and triamcinolone acetonide. The invention is characterized in that the cream also contains octodecyl alcohol or hexadecanol. The triamcinolone acetonide and econazole nitrate cream is more subtle and even, is easy to be daubed and washed on and away from the skin and is harmless to skin, has no odor. No greasiness is to be felt when the cream is daubed on the skin, and the quality is more stable.

Description

technical field [0001] The invention belongs to the field of medicine, and specifically relates to a triamcinolone acetonide mainly used for treating eczema, tinea pedis, tinea corporis, jock itch, tinea versicolor, diaper dermatitis, candida angular cheilitis, and paronychia Econazole cream formulation. Background technique [0002] Skin disease is a common disease in our daily life. At present, the incidence of skin disease is high and there are many types. Because it mostly occurs on the body surface, it not only brings physical harm to the patient; it also affects the appearance and appearance of the patient, bringing pain to the patient. to mental damage. [0003] With the continuous improvement of people's living standards in recent years, the demand for treatment of skin diseases and the demand for drugs for skin diseases is also increasing. The medicine for the treatment of dermatosis is of a great variety at present, mostly is various ointment, emulsifiable paste....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K9/06A61K47/34A61P17/00A61P31/10A61K31/4164
Inventor 刘全胜马明夏兵鲁团伟
Owner 刘全胜
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