Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Triamcinolone acetonide and econazole cream and preparation method thereof

The technology of deeconazole cream and econazole nitrate is applied in the directions of anti-inflammatory agent, antifungal agent, ointment delivery, etc., can solve the problems of drug precipitation, low solubility and the like, achieves fast transdermal absorption and simple preparation process , the effect of high stability

Active Publication Date: 2014-06-18
江苏晨牌邦德药业有限公司
View PDF4 Cites 7 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that the solubility of triamcinolone acetonide and econazole nitrate in water is low. When preparing cream, if the drug cannot be dissolved in the oil phase or the water phase, drug precipitation is prone to occur.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Triamcinolone acetonide and econazole cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Triamcinolone acetonide 15g

[0037] Econazole Nitrate 150g

[0038] Isopropyl myristate 1.6kg

[0039] Lauric acid polyethylene glycol glyceride 3.3kg

[0040] Polyethylene glycol 400 2.0kg

[0041] 5% hydroxypropyl cellulose aqueous solution 7.8kg

[0042] Preparation Process:

[0043] (1) Prescription amount: Weigh triamcinolone acetonide and econazole nitrate and dissolve them in isopropyl myristate, then add lauric acid polyethylene glycol glyceride and polyethylene glycol 400 and mix well as the oil phase;

[0044] (2) Add this oil phase to the 5% hydroxypropyl cellulose aqueous solution and stir evenly to obtain a cream.

Embodiment 2

[0046] Triamcinolone acetonide 15g

[0047] Econazole Nitrate 150g

[0048] Isopropyl myristate 4.9kg

[0049] Polyethylene glycol glyceryl laurate 5.0kg

[0050] Polyethylene glycol 400 1.0kg

[0051] 15% hydroxypropyl cellulose aqueous solution 3.9kg

[0052] Preparation Process:

[0053] (1) Prescription amount: Weigh triamcinolone acetonide and econazole nitrate and dissolve them in isopropyl myristate, then add lauric acid polyethylene glycol glyceride and polyethylene glycol 400 and mix well as the oil phase;

[0054] (2) Add this oil phase to the 5% hydroxypropyl cellulose aqueous solution and stir evenly to obtain a cream.

Embodiment 3

[0056] Triamcinolone acetonide 15g

[0057] Econazole Nitrate 150g

[0058] Isopropyl myristate 3.3kg

[0059] Polyethylene glycol glyceryl laurate 4.9kg

[0060] Polyethylene glycol 400 2.0kg

[0061] 10% hydroxypropyl cellulose aqueous solution 4.5kg

[0062] Preparation Process:

[0063] (1) Prescription amount: Weigh triamcinolone acetonide and econazole nitrate and dissolve them in isopropyl myristate, then add lauric acid polyethylene glycol glyceride and polyethylene glycol 400 and mix well as the oil phase;

[0064] (2) Add this oil phase to the 5% hydroxypropyl cellulose aqueous solution and stir evenly to obtain a cream.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses triamcinolone acetonide and econazole cream and a preparation method thereof. The cream is prepared by uniformly mixing a water phase and an oil phase, wherein the water phase is a hydroxy propyl cellulose water solution and the oil phase is prepared by virtue of the following steps: dissolving triamcinolone acetonide and econazole in isopropyl myristate, then adding dodecylicpolyethylene glycol glyceride laurate and polyethylene glycol 400 and uniformly stirring. Compared with the prior art, the medicament disclosed by the invention exists in the cream in a nanometer form, and is high in stability, rapid in transdermal absorption, simple in preparation process, free of use of complicated emulsion preparation equipment and suitable for the requirements of large-scale production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a triamcinolone acetonide-econazole compound preparation for external use, in particular to a triamcinolone acetonide-econazole cream and a preparation method thereof. Background technique [0002] Dermatomycosis is the abbreviation of a large class of skin diseases caused by fungi that infect the skin, mucous membranes and adnexa. This disease belongs to common disease, frequently-occurring disease, and the crowd prevalence rate can be as high as more than 20% in hot and humid areas. There are many kinds of pathogenic bacteria that cause skin fungal infections. For heterosexual antigens, the body often produces more obvious allergic reactions to pathogenic fungi that invade the skin. Clinically, it can be manifested as eczema dermatitis-like appearance, itching, ringworm rash, and severe secondary bacterial infection. [0003] Triamcinolone acet...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61K9/06A61P31/10A61P29/00A61P17/04A61P37/08A61K31/4174
Inventor 张德芳
Owner 江苏晨牌邦德药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com