67results about How to "Fast transdermal absorption" patented technology

The invention relates to the field of medical / cosmetic apparatuses, and in particular relates to mucosa-repairing gel containing human-like collagen, wherein the rapid transdermal absorption of the human-like collagen can be promoted. The mucosa-repairing gel containing human-like collagen can be used for repairing the mucosa in the medical / cosmetic field. The mucosa-repairing gel contains the human-like collagen, Carbomer, glycerol, sodium hyaluronate, polysorbate-80 and water.

The invention relates to the field of medical / cosmetic apparatuses, and in particular relates to scar-repairing silica gel containing human-like collagen, wherein the rapid transdermal absorption of the human-like collagen can be promoted. The scar-repairing silica gel can be used for repairing hyperplastic scars or keloids caused by burns, scalds, trauma, operations and the like in the medical / cosmetic field. The scar-repairing silica gel contains the human-like collagen, silica, cyclopentasiloxane, dimethiconol, water and polydimethylsiloxane.

The invention discloses a medical dressing with the effect of promoting wound healing. The medical dressing is mainly prepared from, by weight, 25-35 parts of polyurethane, 4-8 parts of rhizoma drynariae, 5-9 parts of radix astragali, 6-11 parts of herbs of comnon thunia, 6-9 parts of herba asari, 10-14 parts of liquorice roots, 8-12 parts of Chinese elder herbs, 7-11 parts of polygonum cuspidatum, 5-9 parts of herba centellae, 6-9 parts of ligusticum wallichii, 10-12 parts of fineleaf schizonepeta herbs, 9-13 parts of polyvinyl alcohol and 6-10 parts of starch acetate. The medical dressing has the advantages that polyurethane is mixed with traditional Chinese herbal medicine, the medical dressing is reasonable in formula, accurate in compatibility and free of irritation to a wound and has the effects of promoting epithelium ingrowth and accelerating wound healing.

The invention provides a progesterone ethosome. Progesterone is encapsulated in an ethosome. The progesterone ethosome comprises the following components in percentage by weight: 0.1 to 1 percent of progesterone, 1 to 8 percent of lipid materials, 0 to 0.6 percent of cholesterol, 20 to 50 percent of short-chain alcohols, 0 to 3 percent of nonionic surfactant and the balance of water. The preparation method comprises the following steps of: mixing and dissolving the progesterone, the lipid materials, the cholesterol and the short-chain alcohols to prepare an alcohol phase; with stirring, adding the alcohol phase into a nonionic surfactant-containing aqueous phase to prepare primary emulsion under the condition of stirring; homogenizing the primary emulsion under a high pressure to obtain asuspension; stirring the ethosome suspension for 15 to 30 minutes to perform emulsification for the second time; and curing the suspension by cooling the suspension at 0 to 4 DEG C to obtain the progesterone ethosome. Because the high-pressure homogenization method is adopted to prepare the progesterone ethosome, the progesterone ethosome is low in stimulation to skin and high in transdermal delivery ability, and metal ion pollution which is easy to cause by the probe ultrasound method of the traditional homogenization method is avoided. Therefore, the progesterone ethosome is suitable for industrial production. The progesterone ethosome can be prepared into a transdermal drug delivery system, a mucosal drug delivery system, and topical dosage forms, such as a paster, a gel and the like. The progesterone ethosome is mainly applied to hormone replacement therapy, secondary amenorrhea, functional aplastic bleeding, premenstrual syndrome and the like clinically.

Disclosed is a Chinese medicinal gelling agent which comprises, 7.5-12.5 wt% of mentha-camphor, 5.5-8.5 wt% of curcuma longa pieces, 5.5-8.5 wt% of dahurian angelica root pieces, 2.5-4.4 wt% of pollen pieces, 2.5-4.4 wt% of red peony root pieces, 2-4 wt% of nitrogen ketone, 1.5-3 wt% of Carbomer, 0.3-0.5 wt% of polysorbate, 0.1-0.3 wt% of triethanolamine and balancing water. The invention also discloses the preparing process.

The invention relates to the field of medical / beauty equipment, in particular to a hydrogel collagen dressing which is especially suitable for oily skin. The collagen dressing of the present invention comprises water, collagen and macromolecular polymers distributed in the water. It can promote rapid transdermal absorption of collagen, so it is more suitable as a medical / cosmetic collagen dressing in the field of medical treatment or medical cosmetology.

The invention discloses triamcinolone acetonide and econazole cream and a preparation method thereof. The cream is prepared by uniformly mixing a water phase and an oil phase, wherein the water phase is a hydroxy propyl cellulose water solution and the oil phase is prepared by virtue of the following steps: dissolving triamcinolone acetonide and econazole in isopropyl myristate, then adding dodecylicpolyethylene glycol glyceride laurate and polyethylene glycol 400 and uniformly stirring. Compared with the prior art, the medicament disclosed by the invention exists in the cream in a nanometer form, and is high in stability, rapid in transdermal absorption, simple in preparation process, free of use of complicated emulsion preparation equipment and suitable for the requirements of large-scale production.

The invention provides a hydrobromic acid lappaconitine solid lipid nano particle and a preparation method thereof. The hydrobromic acid lappaconitine solid lipid nano particle is prepared from the following components, by weight percent: 0.1-1% of hydrobromic acid lappaconitine, 1-8% of lipid material, 0-5% of phospholipid, 0.5-10% of emulsifying agent and the balance water. The preparation method comprises the following steps: mixing the emulsifying agent and the water fully and evenly and preparing a water phase; mixing the hydrobromic acid lappaconitine, the lipid material and the phospholipid fully, melting and preparing an oil phase; heating the water phase and the oil phase respectively to 65-85 DEG C, adding the water phase into the oil phase under a stirring condition and preparing primary emulsion; emulsifying the primary emulsion at high pressure evenly and obtaining suspensoid liquid; and putting the suspensoid liquid under a condition of 0-4 DEG C, cooling, solidifying andpreparing the hydrobromic acid lappaconitine solid lipid nano particle. The invention adopts a high-pressure even emulsification method to prepare the hydrobromic acid lappaconitine solid lipid nanoparticle, does not need to use an organic solvent and is suitable for large industrialized production.

The invention relates to a flurbiprofen cataplasm preparation. The flurbiprofen cataplasm preparation consists of a back lining layer, a medicine depot and a protective layer, and is characterized in that the medicine depot is prepared from the following components in percentage by weight: 0.2% to 0.5% of flurbiprofen as an active ingredient and 5% to 10% of oil phase component; the oil phase component is prepared from caprin and glycerol monolaurate according to a mass ratio of 1:(0.3-0.4); the flurbiprofen is dispersed into the oil phase, and the part using as the water phase component is used for neutralizing with 5% to 10% of sodium polyacrylate as a water phase component, 20% to 40% of moisturizing agent, 0.5% to 1.5% of Carbomer 980, 1.5% to 3% of CMC-Na (sodium carboxymethylcellulose), 0.1% to 0.2% of NMP (N-methyl pyrrolidone), 0.2% to 0.4% of dihydroxyaluminum aminoacetate, 0.1% to 0.3% of EDTA-2Na, 1% to 3% of filling agent, and the balance of water.

The invention provides flurbiprofen cataplasm. The cataplasm is composed of a backing layer, a drug reservoir and a protective layer. The cataplasm is characterized in that the drug reservoir is prepared from the following components in percentage by weight: 0.2%-0.5% of flurbiprofen as an active component, 5%-10% of an oil phase component, 5%-10% of partially neutralized sodium polyacrylate as an aqueous phase component, 15%-20% of glycerol, 0.2%-0.4% of aluminum glycinate, 0.1%-0.3% of sodium calcium edetate, 1%-1.5% of carbomer 934, 1.5%-3% of sodium carboxymethyl cellulose (CMC-Na), 0.05%- 0.1% of a pH adjusting agent and gellan gum, 1%-1.5% of L-glycine, 1%-3% of a filler and the balance of water, wherein the oil phase component is prepared from castor oil and benzyl alcohol, the ratio of castor oil to benzyl alcohol is 1 to (0.08 to 0.12), the aqueous phase component and water form hydrogel, the filler is arranged in the hydrogel dispersedly, and the oil phase component is emulsified and disperses in the hydrogel to form the drug reservoir.

The present invention discloses a compound gel preparation-compound tretinoin gel preparation for curing acnes. It is made up by using carbomer, glycerine, propylene alcohol, Tween, triethanolamine, clindamycin phosphate, tretinoin, EDTA and distilled water as raw material through a certain preparation process. Said invention also provides the concrete steps of its preparation method.

The invention discloses a flurbiprofen cataplasm, which consists of a backing layer, a medicament storage space and a protective layer, wherein the medicament storage space consists of the following components in percentage by weight: 0.2 to 0.5 percent of flurbiprofen serving as an active ingredient, 5 to 10 percent of an oil-phase component, 5 to 10 percent of partial neutralization sodium polyacrylate, 20 to 40 percent of a humectant, 0.5 to 1.5 percent of carbomer 980, 1.5 to 3 percent of CMC-Na (sodium carboxymethyl cellulose), 0.2 to 0.4 percent of dihydroxyaluminium aminoacetate, 0.1 to 0.3 percent of EDTA-2Na (disodium ethylene diamine tetraacetic acid, 0.5 to 0.7 percent of tween 80, 1 to 3 percent of a filler and the balance of water, wherein the oil-phase component is prepared from caprin, oleic acid and peregal A-20 in a mass ratio of 1:(0.2 to 0.3):(0.2 to 0.3), and the partial neutralization sodium polyacrylate, the humectant, the carbomer 980, the CMC-Na, the dihydroxyaluminium aminoacetate, the EDTA-2Na and the tween 80 form a water-phase component.

The invention discloses a biological scalp and hair follicle nourishing and hair growing essence and a preparation method thereof. The essence is added with a human skin stem cell factor nano liposome-exosome complex cultured and prepared by using a human skin stem cell isolation, amplification and culture technique, and supplemented with a Chinese herbal medicinal extract essence to organically combine scalp, hair follicles and hairy roots, so that the growth environment of hair is fundamentally improved, the scalp cell activity and density are improved, hair transformation is promoted, the scalp cell activity and density are improved and the functions of increasing the hair, nourishing the hair and caring the hair are achieved.

The invention relates to drug for curing vitiligo and a preparation method thereof, in particular to Chinese medicine cataplasm for curing vitiligo and a preparation method thereof. The cataplasm is prepared by processing the following materials: tribulus terrestris, gastrodia tuber, black snake, psoralea fruit, safflower, Chinese angelica root, red sage root, prepared tuber of multiflower knotweed, dark plum, astragalus root, dodder, pyrite, gromweel, white mulberry fruit and boneol. The cataplasm is specially used for curing vitiligo, has high drug-loading rate, good air permeability and high moisture retention, is fast in transdermal absorption, and has effective curative effect; the cataplasm can be repeatedly peeled and adhered, drug administration can be terminated at any time, the skin compatibility is good, and the cataplasm has no irritation and irritability; and the Chinese medicine cataplasm has the effects of dispelling wind and eliminating dampness, promoting blood circulation to remove blood stasis and nourishing liver and kidney, has the advantages that the Chinese medicine cataplasm is fast to become effective after treatment, the curative effect is determined, vitiligo is different to recur, and the like, and is used for curing 230 cases totally, and the effective rate reaches more than 94 percent.

The invention relates to an external coating pharmaceutical composition for treating burn and scald and process for preparation, wherein the composition comprises the raw material herbs of sanguisorba root, boneol, and allume by the following weight proportioning through disintegrating and frying, garden burnet root 500 parts, borneol 15-50 parts, allume 10-50 parts. The invention also provides the method of treatment.

The invention discloses a composition for treating xerostomia and oral diseases. The composition for treating xerostomia and oral diseases comprises the following ingredients: a humectant, a solvent, a thickener, a pH regulator, an essence and a preservative. The composition for treating xerostomia and oral diseases can further comprise one or more active ingredients beside the ingredients; and the pharmaceutical composition containing the active ingredients has the function of treating xerostomia and oral diseases. Various xerostomia symptoms can be greatly relieved; meanwhile, the oral diseases of gingivitis, angular cheilitis, oral ulcer, rampant caries and the like caused by the xerostomia symptoms can be treated; multiple choices are provided in flavor, so that the requirements of different people can be met; and therefore, the composition has a wide application market in the future.

The invention discloses isoconeazole nitrate liposome nanoparticles creams and a preparation method of the same. The isoconeazole nitrate liposome nanoparticles creams and the preparation method of the same comprise 0.5 - 3 wt% of the isoconazole nitrate, 1 - 10 wt% of lipid materials, 20 - 50 wt% of oil phase composition, 3 - 15 wt% of humectants, 0.5 - 2 wt% of antioxidants, 1 - 5 wt% of emulsifiers, 0.5 - 2 wt% of preservatives, 0.2 - 1 wt% of buffer salt, 40-70 wt% of water. The isoconeazole nitrate liposome nanoparticles creams and the preparation method of the same comprise weighing raw materials of various component according to prescription dosages, preparing isoconeazole nitrate liposome nanoparticles suspension by utilizing melt-homogenization, preparing oil phase, preparing water phase, and preparing the isoconeazole nitrate liposome nanoparticles creams. The isoconeazole nitrate liposome nanoparticles creams and the preparation method of the same have the advantages of high physical stability, high drug stability, good antifungal efficacy and long acting time of drugs.

The present invention relates to a Xuefu Zhuyu ointment preparation with the functions of promoting blood circulation removing blood stasis, activating circulation of qi and stopping pain and its preparation method. It is made up by using 11 Chinese medicinal materials of Chinese angelica root, peach kernel, carthamus flower, red peony root, ligusticum root, licorice root and others through a certain preparation process, and can be made into ointment preparation or cataplasma preparation form.

The invention relates to nasal mucosa repair human-like collagen gel. The nasal mucosa repair human-like collagen gel comprises, by weight, 0.1-1% of human-like collagen, 0.5-1% of carbomer, 20-30% of glycerinum, 0.1-0.5% of allantoin, 0.005-0.02% of sodium hyaluronate, 0.09-0.1% of sodium hydroxide, 0.1-0.5% of ethylparaben, 0.01-0.05% of menthol, 0.4-0.6% of polysorbate 80, and the balance water. The human-like collagen gel can remarkably accelerate transdermal absorption of the human-like collagen when being applied to the skin of a nasal cavity with damaged mucosas, and therefore, by adoption of the human-like collagen gel, better nourishing can be provided, mucosa cell regeneration is stimulated, and damaged nasal cavity mucosa repair is promoted.

The invention provides a cosmetic composition. The composition is composed of 3-10 parts of dendrobium officinale extract, 2-5 parts of moutan bark extract and 1-4 parts of rhodiola rosea extract. Thepreparation method of the dendrobium officinale extract comprises the following steps: cleaning dendrobium officinale, drying the dendrobium officinale in the sun, and pulverizing the dendrobium officinale to 100 meshes or below to obtain fine powder; adding the fine powder into an enzyme extracting solution, and carrying out stirring and enzymolysis extraction for 1-3 hours, wherein low-power ultrasonic treatment is conducted in the extraction process; carrying out enzyme deactivation and filtration after extraction is finished; and adding 70-90% ethanol water solution into filtrate, and carrying out precipitating and filtering to obtain filter residues, namely the dendrobium officinale extract. Preparation methods of the moutan bark extract and the rhodiola rosea extract are the same asthe preparation method of the dendrobium officinale extract. The composition has the characteristics of natural raw materials, no side effect on skin, good effect and quicker absorption, and has a wide application prospect.

The invention relates to a loratadine cream and application thereof for preparing a medicine for treating inflammation and pruritus caused by mosquito bite, belonging to the technical field of medicines. The loratadine cream has the characteristics of small irritation on skink, high transdermal adsorption speed, inflammation resistance, strong itching activity, obvious curative effect, no adverse reaction and simple preparation process, is prepared from a small quantity of raw materials, and is suitable for industrial production.

The invention discloses a drug for treating angina pectoris, which is a compound paster for external application finely made from six medicinal herbs: astragalus, angelica sinensis, white peony root, ligusticum wallichii, radix rehmanniae and mix-fried licorice as effective components through process of water extracting-alcohol precipitating and has the effect of blood-activating and stasis-dissolving, Qi promoting and pain relieving and obvious angina pectoris curing. The ointment body of the paster is fine and smooth, easy to be coated without melting and small volume to facilitate using and carrying and favorable for quick recovery of lesions and has the advantages of stable medicine properties of the soft paster, quick percutaneous absorption, good ventilation capability and gradual drug delivery. Compared with orally taken formulas, the invention has the advantages of no enterohepatic first-passing function, no affect by gastrointestinal degradation and high degree of biological utilization; compared with injections, the invention has the advantages of convenient using and no pain; compared with pastes, the invention has the advantages of accurate dosage of administration and fixed absorption area; compared with black plasters and adhesive plasters, the invention has the advantages of no skin allergy nor clothes pollution, long acting, percutaneous absorption and convenient carrying and using.

The invention relates to an externally applied medicine for treating closed soft tissue injury and belongs to a Chinese medicine for external use. The externally applied medicine comprises 500 to 566 parts of root of red-rooted salvia, 500 to 566 parts of Chinese angelica, 500 to 566 parts of pangolin, 380 to 420 parts of peach kernel, 500 to 566 parts of safflower, 500 to 566 parts of frankincense, 500 to 566 parts of myrrh, 380 to 420 parts of gardenia, 380 to 420 parts of rhubarb and 380 to 420 parts of silk tree albizzia bark. The invention has the advantages that: the externally applied medicine is quick in transdermal absorption, can quickly eliminate mucosal swelling, has a remarkable analgesic effect and an exact therapeutic effect, does not have toxic or side effect and the like.

The invention discloses a pure natural blood circulation promoting, blood stasis removing and pain stopping hydrogen-rich drug composition as well as a preparation method and application thereof. Thedrug composition is prepared from matrine, beta-sitosterol, nicotinamide, resveratrol, olive oleyl alcohol, cortex eucommiae extract, pinus pinaster bark / bud extract, ginger root oil, fructus silybi extract, apple extract, sodium hyaluronate, walnut oil, trehalose, semen coicis extract and peony root extract and is prepared by dissolving the components with a hydrogen-rich ionized water to acquirethe pure natural blood circulation promoting, blood stasis removing and pain stopping hydrogen-rich drug composition capable of relieving pain in various clinical diseases such as scapulohumeral periarthritis, cervical spondylosis, gingival tumefaction and arthritis. In the pure natural blood circulation promoting, blood stasis removing and pain stopping hydrogen-rich drug composition provided bythe invention, by adopting the hydrogen-rich ionized water as a solvent, the bioavailability of a drug is improved; the pure natural blood circulation promoting, blood stasis removing and pain stopping hydrogen-rich drug composition has efficient effects of stopping pain and resisting inflammation, improves the immunity, resists oxidation, is suitable for any people, does not have the toxic and side effects, is convenient to use and gets a breakthrough progress of relieving the pain of human.

The invention provides traditional Chinese medicine paste for regenerating tissues to heal wound. The traditional Chinese medicine paste is prepared from, by weight, 8-15 parts of calomel, 15-25 parts of frankincense, 18-23 parts of myrrh, 3-7 parts of cutch, 20-30 parts of sanguis draxonis, 80-120 parts of plumbum rubrum, 45-60 parts of cera flava, 25-40 parts of hair, 15-30 parts of periostracum serpentis, 300-650 parts of sesame oil, 0.5-2 parts of musk and 5-15 parts of borneol. Purposes of the traditional Chinese medicine paste can be further achieved through a preparation method of the traditional Chinese medicine paste, the traditional Chinese medicine raw materials including the periostracum serpentis and the hair are fried with the sesame oil, medicinal oil with slag removed is filtered, a product is subjected to high temperature treatment with the plumbum rubrum and the cera flava, black unguent is obtained, the unguent is then mixed with a certain proportion of the calomel, the frankincense, the myrrh, the cutch and the sanguis draxonis, and the paste is obtained. The obtained paste is quick in effect, convenient to use and capable of obviously promoting healing of skin wound, reducing generation of scars and improving healing quality.

The invention discloses a medicine ointment for treating myocardial infarction. The poultice of the invention is an external-use compound paste preparation which is refined by main 11 drugs as effective ingredients; the drugs contain Pollen Typhae, Radix Paeoniae Alba, Fructus Trichosanthis, Ramulus Cinnamomi, Rhizoma Pinelliae, Semen Persicae, Flos Carthami, Faeces Trogopterori, Radix Notoginseng and Succinum. The invention has evident effect on treating thrombus and myocardial infarction. The paste body of the poultice is fine, soft and smooth, easy to be coated on cloth and uneasy to melt, easy for carrying and using because of small size and good for quick recovery of the focuses. The poultice has stable drug property and has the characteristics of quick percutaneous absorption, good ventilation property and gradual drug releasing. Compared with the oral preparation, the invention has the advantages of no liver-intestines first-filter action, no influence from gastrointestinal degradation and high bioavailability. Compared with injection, the invention has the advantages of convenient use and no pain. Compared with ointment, the invention has the advantages of accurate dose and fixed absorption area. Compared with black plaster and sticking plaster, the invention has the advantages of no sensibility on skin, no pollution to clothes, long effect, percutaneous absorption and convenient carrying and use.

The invention discloses piroxicam cataplasm. The piroxicam cataplasm comprises back lining layers, medicine storages and protective layers, and is characterized in that the medicine storages comprise, by weight, 1%-2% of piroxicam, 10%-15% of oil-phase components, 5%-10% of partially neutralized sodium polyacrylate, 15%-20% of glycerol, 1%-1.5% of carbomer 934, 1.5%-2% of hydroxyl propyl methyl celluloses (HPMC), pH (potential of hydrogen) regulators, 0.2%-0.4% of dihydroxyaluminum aminoacetate, 0.1%-0.3% of calcium disodium edetate, 0.2%-0.3% of dimethyl sulfoxide (DMSO), 1%-3% of fillers and the balance water, and the piroxicam is used as an active component; the oil-phase components comprise caprin, Vaseline and lauric acid, a weight ratio of the caprin to the Vaseline to the lauric acid is 1-1.2:0.3-0.4:0.08-0.12, and the piroxicam is dispersed in oil phases; the partially neutralized sodium polyacrylate is used as a water-phase component.

The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to an ointment for promoting blood circulation and removing blood stasis, promoting qi and relieving pain, and a preparation method thereof. Platycodon grandiflorum, Chuanxiong, Bupleurum, and licorice are used as raw materials, treated with water extraction, alcohol extraction, or micronization, and then used as the main drug and mixed with a base to make ointments, plasters, and cataplasms for external use, which are non-irritating to the skin Non-toxic, stable in nature, no hepatic first-pass effect, not affected by gastrointestinal degradation, high bioavailability.

The invention discloses triamcinolone acetonide and econazole cream and a preparation method thereof. The cream is prepared by uniformly mixing a water phase and an oil phase, wherein the water phase is a hydroxy propyl cellulose water solution and the oil phase is prepared by virtue of the following steps: dissolving triamcinolone acetonide and econazole in isopropyl myristate, then adding dodecylicpolyethylene glycol glyceride laurate and polyethylene glycol 400 and uniformly stirring. Compared with the prior art, the medicament disclosed by the invention exists in the cream in a nanometer form, and is high in stability, rapid in transdermal absorption, simple in preparation process, free of use of complicated emulsion preparation equipment and suitable for the requirements of large-scale production.

The invention relates to the field of medical / cosmetic apparatuses, and in particular relates to scar-repairing silica gel containing human-like collagen, wherein the rapid transdermal absorption of the human-like collagen can be promoted. The scar-repairing silica gel can be used for repairing hyperplastic scars or keloids caused by burns, scalds, trauma, operations and the like in the medical / cosmetic field. The scar-repairing silica gel contains the human-like collagen, silica, cyclopentasiloxane, dimethiconol, water and polydimethylsiloxane.