Ointment of diminishing gore and preparing method

A technology of removing blood stasis and ointment, which is applied in the direction of anti-inflammatory agent, ointment delivery, aerosol delivery, etc., and can solve the problems that there is no disclosure of the preparation method of external medicine-ointment

Active Publication Date: 2009-11-18
TIANJIN HONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] There is no disclosure of external medicament-ointment and its preparation method at present

Method used

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  • Ointment of diminishing gore and preparing method
  • Ointment of diminishing gore and preparing method
  • Ointment of diminishing gore and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0183] Embodiment 1: Take 10 times of the prescription amount, decoct with water twice, use 8 times the amount of water for the first time, decoct for 2 hours, use 6 times the amount of water for the second time, decoct for 2 hours, filter, and combine the filtrates , concentrated under reduced pressure to a relative density of 1.25, cooled to room temperature, added ethanol to make the alcohol content 70%, stirred evenly, allowed to stand for 12 hours to precipitate, took the supernatant to recover ethanol, concentrated under reduced pressure to a thick mixture with a relative density of 1.40 The paste was vacuum-dried at 65° C. to obtain 2.7 kg of dry matter, which was pulverized and passed through a 100-mesh sieve to obtain 2.65 kg of powder. Add 3 times the amount of honey, stir evenly to become a paste, then add 20% sesame oil, fully mix into a paste, get 12.5kg, pack in 10g per bag, and get ointment (every 10 grams of ointment is equivalent to crude drug 10.8 g). Or add...

Embodiment 2

[0184] Embodiment 2: get 10 times of prescription quantity, extract 2 times with 80% ethanol, 8 times of quantity for the first time, extract 1 hour, use 5 times of quantity water for the second time, extract 1 hour, filter, collect filtrate, reduce Concentrate under reduced pressure to a relative density of 1.15, cool to room temperature, add 1 times the amount of ethyl acetate to extract twice, stand and separate layers, take the upper layer to recover ethyl acetate, concentrate under reduced pressure to a thick paste with a relative density of 1.40, vacuum Dry at 65°C to obtain 1.35kg of dry product, pulverize and pass through a 100-mesh sieve to obtain 1.32kg of powder. Add 3 times the amount of honey, stir evenly to be a paste, then add 20% sesame oil, fully mix into a paste, get 6.2kg, pack in 10g per bag, and get ointment (every 10 grams of ointment is equivalent to 21.7 crude drugs g). Or add 8 times the amount of pressure-sensitive adhesive butyl acrylate and mix eve...

Embodiment 3

[0185] Embodiment 3: Get 10 times of prescription quantity, superfine pulverize into the superfine powder of particle diameter≤10 microns on superfine pulverizer, obtain 12.6kg. Add 3 times the amount of honey, stir evenly to be a paste, add 20% sesame oil, fully mix into a paste, get 59.3kg, pack in 10g per bag, and get ointment (every 10 grams of ointment is equivalent to crude drug 2.27 g). Or add 8 times the amount of pressure-sensitive adhesive butyl acrylate and mix evenly to obtain 111.1 kg of paste, which is directly coated on a certain size interlining cloth at 120°C to make a black plaster hard plaster (each 10 grams of paste is equivalent to in crude drug 1.22g). Or add 30% laurocapram and 10 times the amount of substrate, the ratio of polyvinyl alcohol PVA, glycerin, and silica gel is 5:2:8, mix well and evenly into a paste, get 135.8kg, and apply it on a certain size On the interlining cloth, the surface of the paste is covered with a protective film made of pol...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to an ointment for promoting blood circulation and removing blood stasis, promoting qi and relieving pain, and a preparation method thereof. Platycodon grandiflorum, Chuanxiong, Bupleurum, and licorice are used as raw materials, treated with water extraction, alcohol extraction, or micronization, and then used as the main drug and mixed with a base to make ointments, plasters, and cataplasms for external use, which are non-irritating to the skin Non-toxic, stable in nature, no hepatic first-pass effect, not affected by gastrointestinal degradation, high bioavailability.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to an ointment for promoting blood circulation and removing blood stasis, promoting qi and relieving pain, and a preparation method thereof. Background technique [0002] Xuefu Zhuyu Capsule is a classic Chinese patent medicine, the Ministry of Health standard WS 2 -B-0928-91 records the prescription: [0003] Peach kernel (stir-fried) 200g Angelica 150g Citrus aurantium (bran stir-fried) 100g Chuanxiong 75g Bupleurum 50g [0004] Safflower 150g Achyranthes bidentata 150g Radix Paeoniae Rubra 100g Rehmannia glutinosa 150g Bellflower 75g Licorice 50g [0005] Functions and indications: promoting blood circulation and removing blood stasis, promoting qi and relieving pain. Used for blood stasis internal resistance, chest pain or headache, internal heat and depression, insomnia and dreaminess, palpitations, irritability and anger. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61K9/06A61P9/10A61P29/00A61P25/04A61P25/20
Inventor 马洪波李凤阁朱晓晶李永仓
Owner TIANJIN HONGRENTANG PHARM CO LTD
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