Hydrobromic acid lappaconitine solid lipid nano particle and preparation method thereof

Abstract

The invention provides a hydrobromic acid lappaconitine solid lipid nano particle and a preparation method thereof. The hydrobromic acid lappaconitine solid lipid nano particle is prepared from the following components, by weight percent: 0.1-1% of hydrobromic acid lappaconitine, 1-8% of lipid material, 0-5% of phospholipid, 0.5-10% of emulsifying agent and the balance water. The preparation method comprises the following steps: mixing the emulsifying agent and the water fully and evenly and preparing a water phase; mixing the hydrobromic acid lappaconitine, the lipid material and the phospholipid fully, melting and preparing an oil phase; heating the water phase and the oil phase respectively to 65-85 DEG C, adding the water phase into the oil phase under a stirring condition and preparing primary emulsion; emulsifying the primary emulsion at high pressure evenly and obtaining suspensoid liquid; and putting the suspensoid liquid under a condition of 0-4 DEG C, cooling, solidifying andpreparing the hydrobromic acid lappaconitine solid lipid nano particle. The invention adopts a high-pressure even emulsification method to prepare the hydrobromic acid lappaconitine solid lipid nanoparticle, does not need to use an organic solvent and is suitable for large industrialized production.

Description

technical field [0001] The invention relates to a kind of homogenin hydrobromide solid lipid nanoparticles and a preparation method thereof, belonging to the technical field of pharmacy. Background technique [0002] Lappaconite Hydrobromide, C 32 h 44 N 2 o 8 ·HBr·H 2 O) is the alkali hydrobromide of Rabaaconitum, an active ingredient extracted from the root of the ranunculaceae plant Aconitum aconitum. . Mainly by blocking the voltage-dependent sodium ion channel, inhibiting nerve conduction, inhibiting the reuptake of norepinephrine by the presynaptic membrane, increasing the norepinephrine between the synapses, thereby inhibiting the afferent fiber substance P released to exert an analgesic effect. Its analgesic strength is 7 times that of aminopyrine, and its analgesic effect is equivalent to that of peperidine, but it lasts for a long time. It is an excellent non-addictive analgesic, has no teratogenic mutagenic effect, and will not cause Accumulation of poison...

AI Technical Summary

Problems solved by technology

In the prior art, the preparation of solid lipid nanoparticles requires the use of organic solvents, which can easily cause residual organic solvents, resulting in certain toxicity

In addition, the drug loading of solid lipid nanoparticles is low. So far, the drug loading of solid lipid nanoparticles is generally only 1% to 5%. The low drug loading limits the wide application of solid lipid nanoparticles.

And also do not see the report that there is homogenine hydrobromide solid lipid nanoparticle in the prior art

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