45results about How to "Maintain chemical stability" patented technology

A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form comprising a statin compound and at least one liquid fill phase comprising Omega-3 fatty acids. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. The solid phase, liquid phase or coatings may further comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, or therapeutic substances, functional excipients or combinations thereof.

The invention discloses a preparation method for a high flux solvent-resisting organic/inorganic hybridized compound film doped with aminated graphene quantum dot, a prepared compound film and an application of the film. The preparation method for the compound film comprises the steps of interfacial polymerization reaction, chemical crosslinking and solvent activation. According to the invention, the aminated graphene quantum dot is added into an interfacial polymerization monomer solution, so that the separating property and solvent resistance of the film are obviously promoted; the film-making time is shortened in the manner of increasing the cross-linking and solvent activating time; a large quantity of amino groups are loaded on the surface of the aminated quantum dot and can react with an organic phase monomer so as to form a firm covalent bond, so that the performance of the film is promoted while the stability of the quantum dot in the film is obviously promoted. According to the invention, the preparation process is simple and the film has wide application prospect in the fields of organic solution system separation and organic solvent-containing water treatment.

A multi phase soft gelatin dosage form comprising at least one preformed solid dosage form and at least one liquid fill phase. The multi phase soft gelatin dosage forms of the present invention are especially useful to combine at least one solid dosage form and at least one liquid phase for single ingestion. Method and apparatus for manufacturing the multiphase soft gelatin dosage forms are also described. The solid phase, liquid phase or coatings may comprise active pharmaceutical ingredients, nutraceuticals, nutritional supplements, therapeutic substances, functional excipients or combinations thereof.

The invention discloses a composite ultrafiltration membrane and a preparation method thereof. The composite ultrafiltration membrane comprises the following raw materials in portion by weight: 6 to 9 portions of polyether sulfone and 1.4 to 2.2 portions of cellulose powder. The composite ultrafiltration membrane material has good hydrophilicity and overcomes the defects of poor hydrophilicity and weak pollution resistance of a polyether sulfone ultrafiltration membrane material, because cellulose molecular chains are provided with a plurality of hydroxyl groups. The composite membrane material has strong pollution resistance, high water flux, good retention characteristic and high strength, prolongs the service life of the ultrafiltration membrane, and saves the production cost.

The invention discloses an ultra-thin composite film with graphene quantum dots as an intermediate layer and a preparation method of the composite film. The preparation steps of the ultra-thin composite film with the graphene quantum dots as the intermediate layer comprises a graphene quantum dot intermediate layer addition step, an interfacial polymerization reaction step, a chemical crosslinkingstep, and a solvent activating step. The separation performance of the film is significantly improved by adding the graphene quantum dot intermediate layer, the graphene quantum dots have a large amount of hydroxyl groups and carboxyl groups, the hydrophilicity of a base film can be increased, the pore size is reduced, the interfacial polymerization reaction is facilitated, and therefore the separation performance of the film is effectively improved. The preparation process is simple, and the composite film has a good application prospect in the field of organic solution system separation.

The invention relates to the field of biological medicine, and particularly provides an injection preparation of an anti-PD-L1 monoclonal antibody, which comprises the anti-PD-L1 monoclonal antibody with the protein content of 10-60 mg/ml; a buffer agent having a concentration of 10-60 mM; a stabilizer with the concentration of 100 to 150 mM; an osmotic pressure regulator with the concentration of10-100 mM; and 0.005%-0.05% (w/v) of a surfactant; wherein a pH value of the injection preparation is 5.8 to 6.3. The anti-PD-L1 monoclonal antibody disclosed by the invention has relatively high affinity and good biological activity; meanwhile, different auxiliary materials are selected according to the characteristics of the anti-PD-L1 monoclonal antibody, so that the safety and effectiveness of the monoclonal antibody in the preservation process can be guaranteed, and the physical stability, chemical stability and biological stability of the anti-PD-L1 monoclonal antibody can be maintained.

The invention provides a nanofiltration membrane for selectively separating trace organic substances and calcium-magnesium ions. The nanofiltration membrane comprises a porous support layer and a filter skin layer, a first solution and a second solution are subjected to interfacial polymerization reaction and heating treatment in sequence to form the filter skin layer, the first solution is a water solution containing polyamine monomers and acid organic matter monomers, and the second solution is formed by dissolving acyl chloride monomers in an organic solvent; in the first solution, the total mass concentration of the polyamine monomers and the acid organic matter monomers is 0.4-1%, and the acid organic matter monomers account for 35-65%; in the second solution, the mass concentration of the acyl chloride monomers is 0.1-0.2%. The invention further provides a preparation method of the nanofiltration membrane for selectively separating the trace organic substances and the calcium-magnesium ions. The nanofiltration membrane has high rejection rate for the trace organic substances but low rejection rate for the calcium-magnesium ions, and chemical stability and health of nanofiltration water are maintained while the trace organic substances are effectively removed.

The invention provides a copper (II) ion surface imprinted polymer supported by polystyrene. The copper (II) ion surface imprinted polymer is prepared by using an unsaturated quaternary ammonium cation modified salicylaldoxime copper (II) complex as a functional monomer and polyene propyl ammonium salt as a cross-linking agent through copolymerization of framework monomers on the acryloyl polystyrene surface; the imprinted polymer is used as a solid phase imprinted two-position extracting agent of copper (II) and is used for selective enrichment and separation of copper (II) ions in each watersystem; the characteristic and the function of simultaneously extracting counterbalancing anions are realized. An effective method is provided for removing copper (II) ions in various water systems and realizing the auxiliary detection, separation and enrichment of copper (II) ions in various water systems; the copper (II) ion surface imprinted polymer can show the foam, diaphragm plate, filamentor particle forms.

The invention relates to the field of therapeutic antibodies, in particular relates to an anti-programmed cell death-ligand 1 (PD-L1) antibody preparation. The preparation comprises an anti-PD-L1 antibody, a buffer solution and sodium chloride, and added sugar and/or sugar alcohols are absent. The anti-PD-L1 antibody preparation of the invention can maintain antibody stability after long-term storage. In addition, the invention further relates to a use of the anti-PD-L1 antibody preparation in preparing drugs used for the prevention and/or treatment and/or adjuvant treatment and/or diagnosis of tumors or anemia

The invention discloses a substituted di(amino mercapto) benzene hydrochloride and process for preparation, which is prepared by using compounds containing benzeneamine and carbonyl as starting raw material through three-step reactions. It can be used for preparing novel benzopyrene polymers together with dicarboxylic acids through polycondensation, the dissolving property of these polymers can be increased, and fine properties of high thermal stability and chemical stability can be achieved.

The invention relates to a preparation method for forming magnetite nanoparticles in a cellulose acetate membrane. The preparation method comprises: preparing a cellulose acetate membrane; adding 8-hydroxyquinoline, and casting the solution on a glass plate base material through a casting knife; washing the prepared membrane, and soaking in water; drying the film; violently mixing a polyvinyl alcohol polymer, and dissolving in water to obtain a uniform solution; adding ferric chloride, and dropwisely adding sodium hydroxide into the mixed solution; carrying out ultrasonic treatment on the solution through an ultrasonic instrument oscillator, and breaking the material aggregate; and immersing the cellulose acetate membrane into the nanometer composite material solution, discharging the excessive solution, and drying to obtain the cellulose acetate membrane. According to the invention, the membrane prepared by adopting the preparation method is improved in ion removal performance, improved in membrane surface hydrophilicity, good in adsorption performance and mechanical integrity, and capable of being repeatedly used.

The invention relates to a preparation method of a durable high-strength composite concrete expansive material and belongs to the technical field of expansive agents. The preparation method includes:using raw powder of sepiolite as a raw material, modifying the raw material by acidolysis so that sepiolite fiber tows are stripped from particles of the powder, combining the sepiolite fiber tows with blast furnace slag to form high-specific-surface-area fiber tow aggregate by melt drawing, making a network framework with the aggregate while chemical stability and mechanical strength of the blastfurnace dry slag fibers are maintained. Pores among the composite fibers support water-absorbing gel to fill the material herein; the material can effectively absorb water and be expansively modifiedduring use. Composite magnesia is used herein, early expansion of the composite magnesia provides sufficient expansion, the composite magnesia can react continuously later to expand, concrete structure damage due to stress relaxation caused by excessive early expansion is avoided, contraction of concrete can be compensated, and durability of the expansive material herein can be effectively improved.

The invention provides polystyrene-supported anion-cation double exchange type copper (II) ion surface imprinted polymer which is prepared by performing copolymerization with skeleton monomers on polyenoic allyl ammoniated polystyrene surfaces by taking an unsaturated quaternary ammonium cation-modified sulfated aldoxime copper (II) complex as a functional monomer and polyenoic allyl ammonium saltas a cross-linking agent; the polymer can be used as solid-phase blotting bi-site extractant for copper (II) to perform selective enrichment and separation of copper (II) ions in various aqueous systems; the polymer has the function and characteristic of simultaneously extracting counter-anions and can be used in methods for removing the copper (II) ions in the various aqueous systems and methodsfor detecting, and separating and enriching the copper (II) ions in the various aqueous systems in an auxiliary manner; and the anion-cation double exchange type copper (II) ion imprinted polymer canbe in forms of foam, diaphragm plates, fibrils or particles.

The invention relates to a preparation method of resin beads, which mainly solves the problems that the existing catalytic hydrogenation technology is relatively complicated in process, high in cost,high in solvent extraction cost and difficult in effectively utilizing and treating acid residues obtained by a sulfonation method. The preparation method comprises the following steps: adding styrenemonomers into a solvent in the presence of nitrogen, adding a catalyst and triethylamine, dropwise adding a mixed solution of a sulfonating agent and solvent, separating and purifying a product by utilizing a column chromatography, obtaining sulfuryl-containing styrene monomers, adding the styrene monomers and the sulfuryl-containing styrene monomers into a reaction apparatus, adopting a polyvinyl alcohol aqueous solution as the solvent, introducing nitrogen, adding a cross-linking agent, reacting to obtain solid beads, and filtering to obtain the resin beads. The preparation method of the resin beads has the advantages that the heat stability and chemical stability of the resin beads can be kept, and the adsorption efficiency can be increased; and the reusability of the resin beads can be ensured.

The invention discloses solid dispersoid of amorphous-form Simeprevir or Simeprevir salt acceptable to pharmacy and pharmaceutical auxiliary materials and a preparation method of the solid dispersoid. The solid dispersoid comprises the Simeprevir or Simeprevir salt acceptable to pharmacy and the pharmaceutical auxiliary materials, wherein the weight ratio of the Simeprevir or Simeprevir salt acceptable to pharmacy to the pharmaceutical auxiliary materials is 1: (0.1-100). The Simeprevir or Simeprevir salt acceptable to pharmacy is in the amorphous form. After a background peak of the pharmaceutical auxiliary materials is deducted from an X-ray powder diffraction spectrum of the solid dispersoid, no characteristic peak of crystals of the Simeprevir or Simeprevir salt is generated. The solid dispersoid of the amorphous-form Simeprevir or Simeprevir salt acceptable to pharmacy and the pharmaceutical auxiliary materials is good in stability and dispersibility; the dissolution rate of the Simeprevir or Simeprevir salt is increased; bioavailability of pharmaceutical preparations and pharmaceutical absorption of organisms can be improved more conveniently; and under the accelerated test conditions, good physical stability and chemical stability can be maintained. The preparation method of the amorphous-form solid dispersoid is simple, low in cost, good in reproducibility, easy to implement and suitable for industrial production.

Amorphous valgancyclovir hydrochloride has a median particle size of below 100 μm. A process for the preparation of the compound includes dissolving valgancyclovir hydrochloride in at least one solvent, removing the solvents under moisture controlled conditions, and drying the wet mass.