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Isoconeazole nitrate liposome nanoparticles creams and preparation method of the same

A technology of isoconazole nitrate lipid and isoconazole nitrate, which is applied in the field of medicine, can solve the problems of reducing the therapeutic effect of isoconazole nitrate, large particle size of isoconazole nitrate, and short maintenance time, so as to improve skin permeability Effect, good drug stability, low equipment requirements

Inactive Publication Date: 2017-04-26
深圳澳美制药技术开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to overcome the above-mentioned prior art defect, provide a kind of isoconazole nitrate lipid nanoparticle emulsifiable paste and preparation method thereof, aim to solve the existing isoconazole nitrate emulsifiable paste due to the larger particle size of isoconazole nitrate , the uniformity is poor, resulting in less active ingredients that can penetrate the stratum corneum of the skin to reach the lesion, the therapeutic concentration achieved is low, and the maintenance time is short, thus greatly reducing the lack of therapeutic effect of isoconazole nitrate

Method used

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  • Isoconeazole nitrate liposome nanoparticles creams and preparation method of the same
  • Isoconeazole nitrate liposome nanoparticles creams and preparation method of the same

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preparation example Construction

[0040] Correspondingly, based on the above-mentioned isoconazole nitrate lipid nanoparticle cream, the embodiment of the present invention also provides a preparation method of the above-mentioned isoconazole nitrate lipid nanoparticle cream. In one embodiment, the preparation method includes the following steps:

[0041] Step S01. Prepare the raw and auxiliary materials of each component according to the prescription:

[0042] Weigh each raw and auxiliary material according to the components and prescription quantities contained in the isoconazole nitrate lipid nanoparticle cream of the embodiment of the present invention described above;

[0043] Step S02. Prepare isoconazole nitrate solid lipid nanoparticle suspension by melting-homogenization method:

[0044] Adding the isoconazole nitrate and the lipid material in the prescribed amount into water containing a surfactant at 60-90°C after hot-melt treatment, and performing preliminary emulsification treatment to form colos...

Embodiment 1

[0068] The present embodiment provides a kind of isoconazole nitrate lipid nanoparticle emulsifiable cream, it comprises the prescription component as shown in following table 1:

[0069] Table 1

[0070] Component Dosage / g Isoconazole Nitrate 10 Soy Lecithin 60 White Vaseline 90 liquid paraffin 90 Polycetorol Emulsifying Wax 120 glycerin 50 Phenoxyethanol 8 Tween 60 30 Sodium dihydrogen phosphate dihydrate 3.5 Disodium hydrogen phosphate dodecahydrate 1.04 Disodium edetate 0.7 purified water 536.76 total 1000

[0071] Its preparation method is as follows:

[0072] S11. Preparation of isoconazole nitrate solid lipid nanoparticle suspension by melting-homogenization method:

[0073] Under the protection of nitrogen, weigh the prescribed amount of isoconazole nitrate and soybean lecithin and heat them until they are melted and mixed evenly. The molten mixture of azole and soybean lecit...

Embodiment 2

[0081] The present embodiment provides a kind of isoconazole nitrate lipid nanoparticle emulsifiable cream, it comprises the prescription component as shown in following table 2:

[0082] Table 2

[0083] Component Dosage / g Isoconazole Nitrate 10 Hydrogenated Soy Lecithin 70 White Vaseline 80 liquid paraffin 100 stearyl alcohol 120 glycerin 50 Phenoxyethanol 8 Poloxamer 30 Sodium dihydrogen phosphate dihydrate 3.5 Disodium hydrogen phosphate dodecahydrate 1.04 Disodium edetate 0.7 purified water 526.76 total 1000

[0084] Its preparation method is as follows:

[0085] S21. Prepare isoconazole nitrate solid lipid nanoparticle suspension by melting-homogenization method:

[0086] Under the protection of nitrogen, weigh the prescribed amount of isoconazole nitrate and hydrogenated soybean lecithin and heat them until they are melted and mixed evenly. The molten mixture of isoconazole an...

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Abstract

The invention discloses isoconeazole nitrate liposome nanoparticles creams and a preparation method of the same. The isoconeazole nitrate liposome nanoparticles creams and the preparation method of the same comprise 0.5 - 3 wt% of the isoconazole nitrate, 1 - 10 wt% of lipid materials, 20 - 50 wt% of oil phase composition, 3 - 15 wt% of humectants, 0.5 - 2 wt% of antioxidants, 1 - 5 wt% of emulsifiers, 0.5 - 2 wt% of preservatives, 0.2 - 1 wt% of buffer salt, 40-70 wt% of water. The isoconeazole nitrate liposome nanoparticles creams and the preparation method of the same comprise weighing raw materials of various component according to prescription dosages, preparing isoconeazole nitrate liposome nanoparticles suspension by utilizing melt-homogenization, preparing oil phase, preparing water phase, and preparing the isoconeazole nitrate liposome nanoparticles creams. The isoconeazole nitrate liposome nanoparticles creams and the preparation method of the same have the advantages of high physical stability, high drug stability, good antifungal efficacy and long acting time of drugs.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an isoconazole nitrate lipid nanoparticle cream and a preparation method thereof. Background technique [0002] Skin fungal infection is the abbreviation of a large class of infectious diseases such as skin, mucous membranes, hair and nails caused by fungi. This disease belongs to common disease and frequently-occurring disease, and the crowd prevalence rate can be as high as more than 20% in hot and humid areas. Research shows that the overall dermatology drug market ranks ninth in the global drug market, with a market size of US$11 billion. In my country, the incidence rate of skin diseases is very high. According to relevant statistics, the national total prevalence rate is 1.23%, that is, about 16 million people suffer from various degrees of skin diseases. [0003] There are many kinds of pathogenic bacteria that cause skin fungal infections. According to the different ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4174A61K47/24A61K47/28A61P31/10
CPCA61K9/06A61K9/0014A61K31/4174A61K47/24A61K47/28
Inventor 林旭升张潮林刘华吴涛汤明辉李海华张志燕
Owner 深圳澳美制药技术开发有限公司
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