Nasal mucosa repair human-like collagen gel

A technology similar to human collagen and nasal mucosa, applied in medical science, bandages, etc., can solve problems such as the transdermal absorption rate of collagen that has not been paid attention to, and achieve the effects of accelerating transdermal absorption rate, promoting repair, and stimulating mucosal cell regeneration

Active Publication Date: 2017-03-29
SHAANXI GIANT BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But unfortunately, relevant researches pay more attention to the transdermal absorption rate of collagen, but not the transdermal absorption rate of collagen

Method used

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  • Nasal mucosa repair human-like collagen gel
  • Nasal mucosa repair human-like collagen gel
  • Nasal mucosa repair human-like collagen gel

Examples

Experimental program
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preparation example Construction

[0035] There is no special limitation on the preparation method of the human-like collagen gel of the present invention, and its preparation method may include:

[0036] Step A: Prepare Phase A, which consists of 0.5-1% by weight of carbomer, 5-15% by weight of glycerin, 0.005-0.02% by weight of sodium hyaluronate, and 0.1-0.5% by weight of allantoin and the remaining water composition;

[0037] Step B: preparing phase B, which is an aqueous sodium hydroxide solution composed of 0.09 to 0.1% by weight of sodium hydroxide and 1 to 3% by weight of water;

[0038] Step C: preparing phase C, which is a mixture of 0.1-0.5% by weight of ethylparaben and 25-5% by weight of glycerin;

[0039] Step D: preparing phase D, which is composed of 0.01-0.05% by weight of menthol and 0.4-0.6% by weight of polysorbate 80;

[0040] Step E: preparing phase E, the phase E is human-like collagen solution, which contains human-like collagen so that the content of human-like collagen in the human-l...

Embodiment 1

[0052] Embodiment 1. Preparation of human-like collagen nasal mucosa repair gel of the present invention

[0053] Ingredients: Carbomer 0.6%, Glycerin 25%, Allantoin 0.2%, Sodium Hyaluronate 0.01%, Sodium Hydroxide 0.096%, Ethylparaben 0.2%, Polysorbate 80 0.5%, Menthol 0.02% , human-like collagen 0.5%, the balance of water.

[0054] Process operation:

[0055] ① adding carbomer, sodium hyaluronate, glycerin (10% by weight), and allantoin to water and stirring to disperse evenly, as phase A; dissolving sodium hydroxide in water to make aqueous sodium hydroxide solution, as phase B; Mix ethylparaben with glycerin and heat and stir until completely dissolved, as phase C; mix menthol and polysorbate 80 and heat until completely dissolved, as phase D; prepare human-like collagen solution as phase E.

[0056] ②Add phase B to phase A, stir well, add phase C and phase E, stir well, keep warm at 82°C for 90 minutes, cool to 30°C after heat preservation, add phase D, stir well and c...

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Abstract

The invention relates to nasal mucosa repair human-like collagen gel. The nasal mucosa repair human-like collagen gel comprises, by weight, 0.1-1% of human-like collagen, 0.5-1% of carbomer, 20-30% of glycerinum, 0.1-0.5% of allantoin, 0.005-0.02% of sodium hyaluronate, 0.09-0.1% of sodium hydroxide, 0.1-0.5% of ethylparaben, 0.01-0.05% of menthol, 0.4-0.6% of polysorbate 80, and the balance water. The human-like collagen gel can remarkably accelerate transdermal absorption of the human-like collagen when being applied to the skin of a nasal cavity with damaged mucosas, and therefore, by adoption of the human-like collagen gel, better nourishing can be provided, mucosa cell regeneration is stimulated, and damaged nasal cavity mucosa repair is promoted.

Description

technical field [0001] The invention relates to a human-like collagen dressing, in particular to a gel containing human-like collagen which is particularly suitable for nasal mucosa repair, and belongs to the field of health care / medical equipment. Background technique [0002] Human-like collagen was invented by Professor Fan Daidi of Northwest University in China (see Chinese Patent Application Publication CN1371919A), so it is also called Fan's Human-like Collagen or Fan's Human-like Collagen (FHLC). Human-like collagen is a highly biocompatible recombinant collagen that is currently widely used in medical or cosmetic fields. [0003] On the other hand, when collagen dressings are used to moisten and protect the mucous membranes of the nasal cavity, anorectum, and gynecology, the use of collagen dressings often needs to be done indoors (such as the otolaryngology, anorectal, and gynecology departments of hospitals, etc.) , as a product user hopes to be able to complete t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
Inventor 范代娣马晓轩严建亚王淑英常海燕王小军杨婵媛
Owner SHAANXI GIANT BIOTECHNOLOGY CO LTD
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