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Medicament for treating myocardial infarction

A technology of drugs and active ingredients, applied in the field of drugs for the treatment of myocardial infarction, can solve the problems of long treatment cycle, toxic and side effects, etc., and achieve the effect of fast transdermal absorption, stable drug properties, and delicate paste

Inactive Publication Date: 2008-06-18
TIANJIN ZHONGBAO PHARMACY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the drugs for the treatment of myocardial infarction are oral preparations, and no external preparations have been seen. Oral administration has a long treatment cycle and relatively large toxic and side effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: the medicine for the treatment of myocardial infarction (trade name: myocardial infarction ointment)

[0034] prescription:

[0035] Puhuang 150g Salvia 150g White peony root 150g Melon basket 150g Guizhi 90g Pinellia 90g

[0036] 90g peach kernel, 90g safflower, 90g Wulingzhi, 30g Sanqi, 30g amber

[0037] Preparation:

[0038] A. Extraction process:

[0039] (a) Put 30 mesh coarse powders of salvia miltiorrhiza, white peony root, melon basket, cassia twig, pinellia, peach kernel, safflower, wulingzhi, notoginseng, and amber into a percolation tank with an ultrasonic device, and mix with medicinal materials, etc. Measure the solvent 90% ethanol, stir and cover it to make it wet and expand for 1-4 hours. The dynamic ultrasonic device controls the percolation flow rate to 1-3ml / min. Add solvent at any time until the percolation liquid is colorless and odorless, dry and warm. Limit below 60°C;

[0040] (b) Pack the raw Puhuang medicinal material in a cl...

Embodiment 2

[0045] Embodiment 2: the medicine for the treatment of myocardial infarction (trade name: myocardial infarction cataplasm)

[0046] prescription:

[0047] Puhuang 150g Salvia 150g White peony root 150g Melon basket 150g Guizhi 90g Pinellia 90g

[0048] 90g peach kernel, 90g safflower, 90g Wulingzhi, 30g Sanqi, 30g amber

[0049] Preparation:

[0050] A. Extraction process:

[0051] (a) Put 30 mesh coarse powders of salvia miltiorrhiza, white peony root, melon basket, cassia twig, pinellia, peach kernel, safflower, wulingzhi, notoginseng, and amber into a percolation tank with an ultrasonic device, and mix with medicinal materials, etc. Measure the solvent 90% ethanol, stir and cover it to make it wet and expand for 1-4 hours. The dynamic ultrasonic device controls the percolation flow rate to 1-3ml / min. Add solvent at any time until the percolation liquid is colorless and odorless, dry and warm. Limit below 60°C;

[0052] (b) Pack the raw Puhuang medicinal material in a clo...

Embodiment 3

[0057] Embodiment 3: the stability investigation of the drug patch ointment for the treatment of myocardial infarction

[0058] According to the "Technical Requirements for New Drug Research of Traditional Chinese Medicine" promulgated and implemented by the State Drug Administration, the technical requirements for quality stability research of new traditional Chinese medicines are stipulated. The ointment and cataplasm for treating angina pectoris were made according to the established process, and the properties, moisture retention, content and microbiological inspection items were observed at room temperature. The results show that all the control indicators meet the national ointment quality standards, and the quality is stable after being placed at room temperature for six months.

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PUM

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Abstract

The invention discloses a medicine ointment for treating myocardial infarction. The poultice of the invention is an external-use compound paste preparation which is refined by main 11 drugs as effective ingredients; the drugs contain Pollen Typhae, Radix Paeoniae Alba, Fructus Trichosanthis, Ramulus Cinnamomi, Rhizoma Pinelliae, Semen Persicae, Flos Carthami, Faeces Trogopterori, Radix Notoginseng and Succinum. The invention has evident effect on treating thrombus and myocardial infarction. The paste body of the poultice is fine, soft and smooth, easy to be coated on cloth and uneasy to melt, easy for carrying and using because of small size and good for quick recovery of the focuses. The poultice has stable drug property and has the characteristics of quick percutaneous absorption, good ventilation property and gradual drug releasing. Compared with the oral preparation, the invention has the advantages of no liver-intestines first-filter action, no influence from gastrointestinal degradation and high bioavailability. Compared with injection, the invention has the advantages of convenient use and no pain. Compared with ointment, the invention has the advantages of accurate dose and fixed absorption area. Compared with black plaster and sticking plaster, the invention has the advantages of no sensibility on skin, no pollution to clothes, long effect, percutaneous absorption and convenient carrying and use.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a medicine for treating myocardial infarction. Background technique [0002] Excessive blood lipids and cholesterol are the main factors causing thrombosis and myocardial infarction. The treatment and prevention of thrombosis and myocardial infarction starts with lowering blood lipids and cholesterol. At present, there is a classic Chinese patent medicine, the Ministry of Health standard WS 2 -B-0928-91 records the prescription of Xuefu Zhuyu capsule: [0003] Peach kernel (fried) 200g Angelica 150g Citrus aurantium (bran fried) 100g Chuanxiong 75g Bupleurum 50g [0004] Safflower 150g Achyranthes bidentata 150g Radix Paeoniae Rubra 100g Rehmannia glutinosa 150g Bellflower 75g Licorice 50g [0005] Functions and indications: promoting blood circulation and removing blood stasis, promoting qi and relieving pain. Used for blood stasis internal r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8888A61K9/06A61K9/70A61P9/10A61K35/24
Inventor 李建民郝彬
Owner TIANJIN ZHONGBAO PHARMACY
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