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Loratadine cream and application thereof

A cream and emulsifier technology, applied in the field of medicine, can solve problems such as contact dermatitis, allergic reaction, inability to improve inflammation, and achieve the effects of less skin irritation, less skin irritation, and improved transdermal absorption performance.

Active Publication Date: 2011-05-11
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] It is mentioned in the article "Jiangsu Safety Production" (2007 Issue 8, page 45) that for some people with sensitive skin, ingredients such as camphor in toilet water can not improve their local inflammation, but will produce allergic reactions, leading to contact dermatitis

Method used

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  • Loratadine cream and application thereof
  • Loratadine cream and application thereof
  • Loratadine cream and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 Cream

[0037]

[0038]

[0039] Preparation process: first heat and dissolve glyceryl monostearate and stearic acid on a water bath, then add white petrolatum and heat to 80°C to form an oil phase; dissolve loratadine in 1,2-propylene glycol and an appropriate amount of water , then add urea, polysorbate-80 (Tween 80), benzalkonium bromide, add water to 1000g, and heat to 80°C to form a water phase; finally, slowly add the oil phase to the water phase while adding Stir until it condenses, and check the finished product.

Embodiment 2-12

[0041] For convenience of description, Table 1 describes Examples 2-12 below.

[0042] Embodiment 2-12 preparation process is the same as embodiment 1.

[0043] The cream of table 1 embodiment 2-12 loratadine

[0044]

[0045]

[0046] Notice:

[0047] 1. "Example 1" in the table means embodiment 1, and others can be deduced by analogy;

[0048] 2. "Less" in the table means an appropriate amount. The minimum amount of loratadine dissolved with 1,2-propanediol or glycerol;

[0049] 3. The unit of the amount of all components is g.

[0050] The second part pharmacodynamic study of loratadine cream

Embodiment 13

[0051] The influence of embodiment 13 different auxiliary materials on loratadine transdermal absorption rate

[0052] 1. Materials

[0053] 1.1 Instruments:

[0054] Shimadzu HPLC (LC-10AT pump, SPD-10A detector, micro sample injector, N-2000 dual-channel chromatography workstation);

[0055] Improved Franz diffusion cell (provided by Shanghai Kaikai Technology Trade Co., Ltd.); constant temperature magnetic stirrer (Tianjin Autosines Instrument Co., Ltd.);

[0056] Electronic balance (American Ohaosi Technology Co., Ltd.).

[0057] 1.2 Drugs: Loratadine, Shandong New Times Pharmaceutical Co., Ltd. (purity 99.5%).

[0058] 1.3 Reagents: Potassium dihydrogen phosphate, dipotassium hydrogen phosphate, sodium hydroxide, double distilled water, methanol (chromatographically pure), glacial acetic acid (chromatographically pure). The above chemical reagents are all domestically produced.

[0059] 1.4 Animals: Wistar rats, body weight (225±20) g.

[0060] 2. Method

[0061] 2...

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PUM

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Abstract

The invention relates to a loratadine cream and application thereof for preparing a medicine for treating inflammation and pruritus caused by mosquito bite, belonging to the technical field of medicines. The loratadine cream has the characteristics of small irritation on skink, high transdermal adsorption speed, inflammation resistance, strong itching activity, obvious curative effect, no adverse reaction and simple preparation process, is prepared from a small quantity of raw materials, and is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a cream of loratadine and its application in the preparation of medicines for treating redness and itching caused by mosquito bites. Background technique [0002] Loratadine was first listed in Belgium in 1988. It is a very effective oral third-generation antihistamine drug that selectively inhibits peripheral H1 receptors and is a powerful antiallergic drug. [0003] Loratadine has been clinically used to treat allergic rhinitis since it was launched. It has a good clinical effect on alleviating allergic inflammation such as sneezing, runny nose, nasal itching, nasal congestion and eye itching and burning. However, long-term high-dose oral administration may cause serious systemic adverse reactions to skin diseases, which is an undesirable way of administration. [0004] The publication number is CN 1634053A discloses liniment, ointment, spray and aerosol of lora...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4545A61P17/00A61P17/04A61P37/08
Inventor 赵志全
Owner LUNAN PHARMA GROUP CORPORATION
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