Composition for treating xerostomia and oral diseases

A dry mouth and composition technology, which is applied in the field of medicine, can solve the problems that there are no similar drugs, and achieve the effects of fast transdermal absorption, convenient use, and comfortable skin

Active Publication Date: 2016-08-10
北京启慧生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Dry Mouth Gel is a drug developed for the symptom of dry mouth. It belongs to the category of medical devices in the United States. At present, there is no similar drug on the market in China.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0023] Embodiment 1-3, the preparation of the composition for the treatment of xerostomia

[0024] The composition formulations of Examples 1-3 are shown in Table 1.

[0025] Table 1 The formulation of the composition for treating xerostomia

[0026] Element

Features

Example 1

Example 2

Example 3

Diglycerin

moisturizer

—

60g

—

Sorbitol

moisturizer

60g

—

—

Propylene Glycol

moisturizer

—

—

60g

water

solvent

37g

36.1g

36.5g

Sodium carboxymethyl cellulose

thickener

—

3g

2g

gelatin

thickener

2g

—

1g

carrageenan

thickener

0.7g

0.5g

—

potassium citrate

PH regulator

0.2g

—

—

Sodium citrate

PH regulator

—

0.3g

0.3g

lemon zest

flavoring agent

—

0.05g

—

strawberry flavor

flavoring agent

0.05g

—

0.1g

Ethyl p-hydroxybenzoate

preservative ...

Embodiment 4-9

[0032] Embodiment 4-9, the preparation of the composition for treating xerostomia and oral ulcer, angular cheilitis, gingivitis etc.

[0033] The composition formulation of the treatment xerostomia and oral ulcer, angular cheilitis, gingivitis etc. of embodiment 4-9 is as shown in table 2~7:

[0034] Table 2 The composition formulation for the treatment of xerostomia and oral ulcer

[0035] Element

Features

Example 4

Propylene Glycol

moisturizer

60g

water

solvent

35g

Benzocaine

active ingredient

2g

Sodium carboxymethyl cellulose

thickener

2g

carrageenan

thickener

0.7g

Sodium citrate

pH regulator

0.2g

peach essence

flavoring agent

0.05g

Ethyl p-hydroxybenzoate

preservative

0.05g

gross weight

100g

[0036] Table 3 The composition formulation for the treatment of xerostomia and oral ulcer

[0037] Element

Features

Ex...

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PUM

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Abstract

The invention discloses a composition for treating xerostomia and oral diseases. The composition for treating xerostomia and oral diseases comprises the following ingredients: a humectant, a solvent, a thickener, a pH regulator, an essence and a preservative. The composition for treating xerostomia and oral diseases can further comprise one or more active ingredients beside the ingredients; and the pharmaceutical composition containing the active ingredients has the function of treating xerostomia and oral diseases. Various xerostomia symptoms can be greatly relieved; meanwhile, the oral diseases of gingivitis, angular cheilitis, oral ulcer, rampant caries and the like caused by the xerostomia symptoms can be treated; multiple choices are provided in flavor, so that the requirements of different people can be met; and therefore, the composition has a wide application market in the future.

Description

technical field [0001] The invention provides a composition for treating xerostomia and oral diseases, belonging to the field of medicine. Background technique [0002] Sjogren's syndrome (Sjögren's Syndrome (SS), also known as Sjögren's syndrome, is a systemic autoimmune disease characterized by focal lymphocyte infiltration of exocrine glands, involving multiple organs and systems, and is also the most representative autoimmune disease of salivary glands. disease. Clinically, it is divided into two types: primary Sjogren's syndrome (primary SS, pSS) and secondary Sjögren's syndrome (secondary SS, sSS). Epidemiological surveys show that SS occurs more frequently in women, accounting for about 90% of all cases, and the age of onset is concentrated in 30-60 years old. % to 4%, is one of the most common connective tissue diseases. Clinically, pSS is characterized by dry mouth and eyes, accompanied by the production of serum autoantibodies. In severe cases, not only mouth ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K47/10A61K47/32A61K47/36A61K47/38A61K31/245A61K31/155A61K31/573A61K31/525A61K36/195A61K36/704A61K36/315A61K33/06A61K31/045A61K31/4164A61K31/7048A61K31/192A61P1/02
CPCA61K31/045A61K31/155A61K31/192A61K31/245A61K31/4164A61K31/525A61K31/573A61K31/7048A61K33/06A61K36/195A61K36/315A61K36/704A61K45/06A61K47/10A61K47/32A61K47/36A61K47/38A61K47/42A61K2300/00
Inventor 刘素云冯朴纯狄忠黄巧萍
Owner 北京启慧生物医药有限公司
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