9 results about "Artificial salivas" patented technology

The invention discloses a synthetic cannabinoid nucleic acid aptamer and application thereof. The synthetic cannabinoid nucleic acid aptamer is shown as any one of nucleotide sequences SEQ ID NO.1-8. The invention further discloses a synthetic cannabinoid nucleic acid aptamer. According to the invention, a plurality of synthetic cannabinoid structures are taken as positive screening targets, a plurality of non-synthetic cannabinoid structures are taken as negative screening targets, and a plurality of nucleic acid aptamers with high affinity to the plurality of synthetic cannabinoid structures are screened based on a ligands index enrichment system evolution technology; the functional motif combined with the synthesized cannabinoid indazole-3-formamide framework structure is found for the first time. Through verification, the KD value of the aptamer and the inspected synthetic cannabinoid is 0.1-1.3 [mu] M, the detection linear range of ADB-PHETINACA in 50% artificial saliva by a fluorescent dye replacement detection method based on the aptamer is 20-400 ng / mL, the detection limit is 2.1 ng / mL, the sensitivity is high, the detection is rapid, the operation is simple and convenient, and the fluorescent dye replacement detection method can be used for rapid drug screening.

The utility model relates to dental instrument test technical field especially, it relates to a kind of anti-bruxism sleeve endurance test tooling. Including: occlusion controller, configuration is to exert set pressure and carry out set number of occlusion cycle, the occlusion cycle includes loading and unloading operation;Test sink, for containing artificial saliva and immerging to be measured anti-bruxism sleeve;Temperature controller, for the artificial saliva is heated and maintained at set temperature;Tooth model, for fixing the anti-bruxism sleeve, and place in the test sink;Wherein, the occlusion controller includes pressure applying device, for the anti-bruxism sleeve fixed on the tooth model is exerted vertical occlusal force, to simulate human occlusion action.By multiple components cooperation realizes accurate simulation oral environment, occlusion action to test the use effect of anti-bruxism sleeve.

The invention discloses artificial saliva and a preparation method of artificial saliva hydrogel. The artificial saliva is prepared from the following raw materials in parts by mass: 0.5 to 1 g of KCl, 0.2 to 0.4 g of K2HPO4, 0.2 to 0.8 g of NaCl, 0.2 to 0.4 g of KH2P O4, 10.04 to 20.8 g of CaCl2, 1.5 to 3 g of Nacaboxymethlecellulose, 60 to 120 mg of brown moss alcohol, 495 to 1000 ml of natural coconut juice and 5 to 10 ml of herba sarcandrae extract. By selecting the glabrous sarcandra herb extract, anti-inflammatory and anti-tumor treatment is realized, so that the traditional Chinese medicine composition has a remarkable effect on dry mouth caused by radiotherapy; through the form of a gel bead preparation, the beverage is more portable and unique in taste. The gel beads serve as one of oral local administration preparations, and after the gel beads are exploded, drugs can target small glands which are located below oral mucosa and secrete saliva, and the rapid drug effect is achieved. Direct local administration to the oral mucosa may provide rapid drug action, activate small salivary glands within the buccal mucosa, while avoiding systemic drug exposure and off-target effect.

The invention provides an artificial saliva spray. The artificial saliva spray is prepared from the following components in percentage by mass: 0.001 to 0.003 percent of hydrogenated castor oil, 0.02 to 0.07 percent of xanthan gum, 0.01 to 0.03 percent of cyclodextrin, 0.01 to 0.02 percent of calcium chloride, 0.01 to 0.05 percent of dipotassium phosphate, 0.1 to 0.15 percent of potassium chloride, 0.05 to 0.1 percent of sodium chloride, 0.004 to 0.006 percent of magnesium chloride and the balance of water. The artificial saliva suitable for the spray is provided, the dosage is accurate, the good oral cavity adhesion capacity is achieved, and the effect maintaining time is long.

The invention belongs to the technical field of orthodontic medical instruments, and particularly relates to a miniature tubular anterior tooth orthodontic bracket and an orthodontic method thereof.The bracket body is of a hollow circular tubular structure, the tooth attaching end is of a continuous smooth cylindrical surface design and is in linear contact fit with the tooth surface, and the protruding height after adhesion is smaller than or equal to 2 mm; the roughness Ra of the inner wall of the internal force application channel is 0.15-0.25 mu m; the main body is formed by integral compression molding of a medical composite material containing bismuth oxide; the technical prejudice that bonding is unstable and non-metallic materials cannot be developed due to line contact is broken through, and the excellent performance that the X-ray development definition is greatly improved, the shear bonding strength is 18.5 + / -1.2 MPa, the hardness retention rate is larger than or equal to 90% after artificial saliva soaking for 180 days, and the mucous membrane compression pain occurrence rate is reduced is achieved; the single bracket can independently complete the anterior tooth local deformity correction function without being matched with a full-mouth bracket system, the anterior tooth gap closing period is averagely shortened, and the social concealment, the clinical operation efficiency and the patient comfort are remarkably improved.

The invention discloses a biomimetic fluid-based medical equipment phthalate migration test method, which is characterized by comprising the following steps: (1) taking artificial saliva as a leaching solution; the method comprises the following steps: soaking a to-be-detected medical equipment pipeline sample in a glassware according to the ratio of the sum of the internal area and the external area (cm < 2 >) to the volume (mL) of a leaching solution of 2: 1, and standing for 24 hours at the constant temperature of 37 + / -1 DEG C; (2) transferring a proper amount of the extract liquid into a test tube, then adding n-hexane, fully oscillating for 10 minutes, then centrifuging, sucking an upper-layer n-hexane solution by using a glass dropper, and extracting by using a solid-phase extraction column to obtain an extracting solution; repeating the extraction step twice; (3) mixing the three extracting solutions, evaporating the mixed extracting solutions in a vacuum rotary evaporator until the mixed extracting solutions are nearly dry, and then adding n-hexane to dissolve the mixed extracting solutions to obtain a detection solution; and analyzing the detection liquid by using a gas chromatograph-mass spectrometer, and testing the migration volume of the phthalate.

The present application relates to the technical field of oral products, and specifically discloses a manganese tungstate nanoparticle / hydrogen peroxide composition for tooth whitening and a preparation method thereof. The preparation method comprises the following steps: preparing manganese tungstate nanoparticles, dispersing tungsten hexacarbonyl and a surfactant in a first organic solvent, adding an oleic acid / oleylamine ligand pair under first reaction conditions, then stirring and reacting under second reaction conditions, cooling, centrifuging, washing, and drying to obtain the manganese tungstate nanoparticles. The manganese tungstate nanoparticles / polyethylene glycol composite material is prepared by dispersing the manganese tungstate nanoparticles and a polyethylene glycol derivative in a second organic solvent, uniformly stirring, and nitrogen drying. The manganese tungstate nanoparticle / polyethylene glycol composite material is dissolved in artificial saliva, hydrogen peroxide solution is added and mixed to obtain the manganese tungstate nanoparticle / hydrogen peroxide composition for tooth whitening.

The invention discloses a method for efficiently producing volatile fatty acid by anaerobic fermentation of white spirit vinasse based on rumen microorganisms, which comprises the following steps: S1, substrate pretreatment: selecting white spirit vinasse as a fermentation substrate, and sequentially drying and crushing the fermentation substrate to obtain a pretreated substrate; s2, construction of an inoculation system: taking fresh rumen fluid as an inoculation source, mixing the fresh rumen fluid with an artificial saliva culture medium and a pretreatment substrate, adjusting the concentration of the substrate to 2-5% (w / v), and constructing a fermentation system; s3, anaerobic fermentation: placing the fermentation system in an anaerobic environment, culturing at 37-40 DEG C for 3-7 days, and maintaining the pH value of the fermentation system at 5.5-6.0 in the culture process. According to the method, efficient hydrolysis and conversion of the Baijiu vinasse are achieved, and the total yield of volatile fatty acid is remarkably increased.

The utility model belongs to the technical field of analysis and detection equipment discloses a kind of cigarette tipping paper stick lip property testing device, including datum plate, smearing mechanism and measuring assembly. When the stick lip property of cigarette tipping paper surface that smears artificial saliva is measured, first, cigarette tipping paper is placed on datum plane, then artificial saliva is smeared on cigarette tipping paper surface by smearing mechanism, and then measuring piece is released from the top end of sliding slot without initial speed, so that measuring piece moves from the top end of sliding slot to cigarette tipping paper along sliding slot under the action of gravity, and the distance of measuring piece moving on cigarette tipping paper is read by scale line. When the stick lip property of cigarette tipping paper surface that does not smear artificial saliva is measured, artificial saliva does not need to be smeared on cigarette tipping paper surface by smearing mechanism. Smearing artificial saliva on cigarette tipping paper surface by smearing mechanism can accurately control the smearing amount of artificial saliva, make smearing more uniform, reduce measurement error, and improve the accuracy of measurement result.