47 results about "Artificial salivas" patented technology

The invention relates to a method for detecting a release situation of nicotine in buccal tobacco products, which is characterized by comprising the steps of simulating the release situation of the nicotine in the buccal tobacco products in the human mouth, instantly quantifying the release quantity and the release speed and then detecting the release speed and the release degree of the nicotine in the buccal tobacco products. The release and the collection of the nicotine are realized through a release and collection device in vitro; by means of the device, the release process of the nicotine in the buccal tobacco products in the human mouth can be simulated and nicotine release solutions can be the instantly collected, wherein the release process is a process that the nicotine is continuously extracted from the buccal tobacco products by utilizing artificial saliva at a constant temperature; and the detection of the nicotine content in the release solution is realized through a high performance liquid chromatography. The method has the advantages: the release speed and the release degree of the nicotine in various buccal tobacco products can be rapidly and accurately detected with good repeatability, high sensitivity and short detection period and is suitable for the rapid analysis of mass samples for different industries and different purposes.

The invention discloses oral care composition for treating xerostomia and an application of the oral care composition in toothpaste. The oral care composition for treating xerostomia contains Chinese herbal medicine extract and bio-enzyme, wherein the Chinese herbal medicine extract is one or more of dendrobium extract, radix polygonati officinalis extract and radix ophiopogonis extract; the bio-enzyme is one or more of lysozyme, lactoperoxidase, amylase, amyloglucosidase and glucose oxidase. The oral care composition has the effect of relieving xerostomia, on one hand, the oral care composition can stimulate salivary secretion, and on the other hand, the oral care composition contains a component similar to protein or enzyme in saliva, thereby being capable of playing the role of artificial saliva, having the sterilization effect and being capable of relieving discomfort caused by xerostomia after use.

The invention relates to a method for measuring lip sticking force of cigarette tipping paper, and belongs to the technical field of analysis and detection. According to the method, bonded tipping paper and artificial mouthpiece leather are clamped between two clamps through artificial saliva, the two clamps do relative motion, and force value changes in the test process are collected through a force value sensor and a displacement sensor. The bonding area of the tipping paper and the artificial mouth skin is divided by the tested maximum stripping force to obtain the lip bonding force of thecigarette tipping paper in unit area. The method can accurately quantify the adhesive force of the cigarette tipping paper to the lips, subjective factor influences and difference characterization caused by traditional artificial sensory evaluation can be avoided, the method is more objective and efficient, has good repeatability, high sensitivity and simple operation, and has advantages in material admission, quality control and product upgrading in the tobacco industry.

The invention relates to a determining method and device of nicotine in oral smokeless tobacco products, and belongs to the technical field of novel tobacco detection. The method comprises the following steps of putting a piece of piled filtration paper into a dissolution pool (5), wetting by artificial saliva, weighing 0.5-2.0g of oral smokeless tobacco products, filling into the dissolution pool (5) which is filled up with the piece of filtration paper, placing a collection bottle (6) below the dissolution pool (5), regulating the height of a support (7), and closing a door of a constant-temperature box (4) for dissolution test; and analyzing a release liquid which is collected in real time quantitatively by a high performance liquid chromatograph. An in-vitro dynamic release device consists of a constant-temperature water bath pot (1), a solvent storage bottle (2), a constant-flow pump (3), the constant temperature box (4), the dissolution pool (5), the collection bottle (6) and the support (7). The method provided by the invention has the advantages that operation is simple, convenient and rapid, and selectivity is good; the device has the advantages of simple structure and time and labor conservation, and is convenient to dismount and clean.

The invention discloses an in-vitro simulation detection method for the bioavailability of nicotine in a tobacco gum base product. The in-vitro simulation detection method for the bioavailability of the nicotine in the tobacco gum base product is characterized by comprising specific steps of: (1) releasing and collecting nicotine in vitro; (2) performing quantitative analysis on the content of the nicotine in collected liquid and residual samples; and (3) drawing an in-vitro nicotine bioavailability curve. The method has the advantages that: the chewing behavior of the mouth of a person can be simulated well by using a self-designed pressure changing type simulation chewing machine; for the rationally prepared artificial saliva and the continuous updating of the artificial salvia in a chewing cavity, nicotine in the tobacco gum base product can be released fully; as nicotine release liquid can be collected in real time for detection and the test result is close to the true condition of the product used by a person, the specific data support can be provided for judging the safety of the tobacco gum base product and performing quality regulation, control and research. The method hasthe advantages of good repeatability, high sensitivity and short detection period, and is suitable for rapid analysis of samples in industries, such as tobacco, food, medicines and the like.

The invention relates to artificial saliva, which comprises a plurality of inorganic salt, HPMC, a preservative, a flavoring agent and other components. The artificial saliva has the following advantages that: (1) the artificial saliva can rapidly improve symptoms of a patient suffering from xerostomia, and can maintain the function in a longer period; (2) the artificial saliva has good stability; and (3) the artificial saliva has a good mouthfeel when in use.

Artificial salivary gland devices and assemblies are provided. The present disclosure provides artificial salivary pump / gland devices and assemblies, and related methods of use. One embodiment utilizes the interstitial / marrow fluid reservoir within the underlying mandibular or maxillary bone as a source for replacement saliva. The salivary pump / assembly, which is implantable in the mandibular or maxillary bone as a dental implant and driven by incidental tooth contact and masticatory forces, harvests interstitial / marrow fluid and treats it via semi-permeable membrane technology and soluble particles as a continuously available saliva replacement. Masticatory forces and tooth contact power the pump to both harvest interstitial / marrow fluid and drive flow through a bed of ion-exchange resins and / or soluble particles to adjust fluid chemistry providing a continuously available saliva-like solution. Exemplary devices and assemblies can also be utilized to introduce beneficial bacteria into the oral cavity and / or be utilized as a delivery system for drugs / therapeutic agents.

The invention discloses a spray for treating radioactive xerostomia and a preparation method thereof. The spray is prepared by adding a plurality of plant extracts based on the conventional artificial saliva and has a cool sweet taste and a plurality of effects, such as diminish inflammation, antibiosis, tooth cleaning, whistle wetting and the like. Compared with the conventional artificial saliva, the spray of the invention has the advantages that: because menthol, momordica glycosides V and stevioside A are added in the formula of the spray, the product has the cool sweet taste and patients enjoy in mouthfeel, and by fully meeting the requirements of the patients with diabetes, obesity and the like, disadvantageous consequences probably caused by a sweetener contained in the product are avoided; because a Chinese globeflower extract, a liquorice root water extract, a wild chrysanthemum water extract and a perilla water extract are added in the spray, the product has the cool sweet taste and also the plurality of effects, such as diminish inflammation, antibiosis, tooth cleaning, whistle wetting and the like, and contributes to the maintenance of oral hygiene and the prevention of oral infection; and because the using times is a few, the spray contributes to the effective remission of thirst.

The invention belongs to the technical field of a dental biological medical material and particularly relates to a tooth desensitizer containing phosphosilicate glass as well as a preparation method and application thereof. After the phosphosilicate glass is contacted with a phosphate buffer solution, artificial saliva or simulated body fluid, phosophate ions as well as calcium, strontium, magnesium, zinc, potassium or sodium ions can be released rapidly, a SiO2-enriched silica gel layer is formed on the surface of a material, Ca<2+> and PO4<3-> form a CaO-P2O5 amorphous layer on the SiO2 silica gel layer and the CaO-P2O5 amorphous layer is crystallized to be transformed into hydroxyapatite (HA), so that a dentinal tubule is rapidly closed and hemodia is treated. After the phosphosilicateglass and composite resin are compounded, the phosphosilicate glass is rapidly photocured through photo-initiated polymerization curing to cover the surface of a tooth, so that the dentinal tubule canbe closed rapidly and the hemodia is treated. The tooth desensitizer can block the dentinal tubule rapidly and effectively and induce a dentin layer to be rapidly repaired.

Artificial salivary gland devices and assemblies are provided. The present disclosure provides artificial salivary pump / gland devices and assemblies, and related methods of use. One embodiment utilizes the interstitial / marrow fluid reservoir within the underlying mandibular or maxillary bone as a source for replacement saliva. The salivary pump / assembly, which is implantable in the mandibular or maxillary bone as a dental implant and driven by incidental tooth contact and masticatory forces, harvests interstitial / marrow fluid and treats it via semi-permeable membrane technology and soluble particles as a continuously available saliva replacement. Masticatory forces and tooth contact power the pump to both harvest interstitial / marrow fluid and drive flow through a bed of ion-exchange resins and / or soluble particles to adjust fluid chemistry providing a continuously available saliva-like solution. Exemplary devices and assemblies can also be utilized to introduce beneficial bacteria into the oral cavity and / or be utilized as a delivery system for drugs / therapeutic agents.

The invention relates to a method for measuring a lip sticking force of cigarette tipping paper, and belongs to the technical field of analysis and detection. According to the method, a thermo-mechanical analysis method is adopted, so that a sample is in a temperature environment similar to an oral cavity, tipping paper and artificial mouth skin are effectively bonded by adopting artificial saliva, then a certain mechanical force is applied to the bonded sample by using a drawing die, and the change process of the size or deformation quantity of the sample along with time in a certain direction is measured. The maximum tensile force of a tested displacement mutation point is divided by the bonding area of the tipping paper and the artificial mouth skin to obtain the lip bonding force of the cigarette tipping paper in unit area. The method can accurately quantify the adhesive force of the cigarette tipping paper to the lips, subjective factor influences and difference characterization caused by traditional artificial sensory evaluation can be avoided, the method is more objective and efficient, has good repeatability, high sensitivity and simple operation, and has advantages in material admission, quality control and product upgrading in the tobacco industry.

The invention provides artificial saliva for an oral tobacco research and a preparation method thereof, and belongs to the technical field of artificial saliva preparation. The artificial saliva of the invention is prepared from an aqueous solution comprising the following mass concentration components: NaCl 0.392~0.408g / L, KCl 0.392~0.408g / L, CaCl2.2H2O 0.7791~0.8109g / L, NaH2PO4.2H2O 0.7644~0.7956g / L, Na2S.2H2O 0.0049~0.0051g / L, urea 0.98~1.02g / L, carboxymethylcellulose 2.94~3.06g / L, wherein the artificial saliva has a pH of 7.0. The nicotine detection of the oral tobacco form the artificialsaliva of the invention is similar to the artificial saliva. The artificial saliva has good stability and a certain viscosity. The formula has a small variety of ingredients and is a common compound,and has a low cost.

The sensor array modified by polypyrrole-PVC film comprises: with Pt-electrode as substrate, polymerizing conductive polypyrrole by electrochemical method; then, covering the PVC film modified by 8 smell-sensitive agents to form 8 solid smell sensors and form an array with a 217-type saturated dual-salt bridge calomel electrode, wherein it can use open-loop potential to obtain the electric response of target solution in the sensor interface, and detects data matrix to process the smell feature by PCA and cluster analysis. This invention improves sensor physical stability, and uses artificial saliva for stable interface as the AI application.

The invention discloses a method for measuring a lip sticking force of tipping paper for cigarettes. The method comprises the following steps of testing a degree of a contact angle theta formed by artificial saliva droplets on the surface of the tipping paper for the cigarettes by using a contact angle tester, and establishing a quantitative relation between the angle of the contact angle theta and the lip sticking force of the tipping paper for the cigarettes, so that the lip sticking force of the tipping paper for the cigarettes can be judged. According to the method, the quantitative relation of the consistency between the measurement result of the degree of the contact angle theta formed by the artificial saliva droplets on the surface of the tipping paper for the cigarette and the lipsticking force of the tipping paper for the cigarette is established for the first time, so that the lip sticking degree of the tipping paper is quantified. Compared with the result of artificial smoking assessment, the reproducibility is greatly enhanced.

The invention discloses a method for detecting the influence of a gum-based type tobacco product on the human oral cavity in vitro micronucleus. The method comprises: (1) placing a gum-based type tobacco product to be detected in liquid nitrogen, and freezing; (2) immediately crushing the frozen gum-based type tobacco product by using a crusher; (3) re-freezing; (4) soaking the crushed gum-based type tobacco product by using artificial saliva; (5) carrying out centrifugal separation on the extraction solution; (6) determining the supernatant through an osmotic pressure determining instrument, and adjusting the osmotic pressure to achieve the same osmotic pressure of a cell culture medium; (7) determining the nicotine content in the extraction solution; (8) culturing human oral mucosal epithelial cells as the detection object; (9) adding the extraction solution to the cultured human oral mucosal epithelial cells; and (10) after the incubation, detecting the cell in vitro micronucleus condition by using a high-content imaging instrument.

The invention relates to a method for measuring an apparent sweetening agent of sweet tipping paper, which comprises the following steps of cutting tipping paper with a set area, paving and fixing the tipping paper; dropwise adding artificial saliva to the rough surface of the glass fiber filter disc, standing, clamping the front surface of the glass fiber by using tweezers after the artificial saliva is uniformly dispersed on the glass fiber, enabling the rough surface to be in contact with the front surface of the tipping paper, wiping back and forth along the length direction of the tipping paper, and putting the wiped glass fiber filter disc into a conical flask with a plug; and adding the extract liquor into a conical flask with a plug, carrying out ultrasonic extraction, standing, taking supernate, filtering a membrane, and carrying out chromatographic analysis and determination. According to the measuring method of the technical scheme, the transfer amount of the sweetening agent on the surface of the tipping paper can be accurately detected, technical support is provided for directly knowing transfer of the sweetening agent on the surface of the tipping paper, and detection support is provided for controlling the transfer amount of the sweetening agent on the surface of the tipping paper.

The invention relates to a method for detecting lip sticking force of cigarette tipping paper, and belongs to the technical field of analysis and detection. According to the method, through repeated smoking assessment and sample comparison, it is found that the lip sticking performance of the cigarette tipping paper is closely related to the processing technology, a certain waterproof material isadded into the printing coating surface, and lip sticking of the tipping paper can be effectively avoided. Therefore, the lip adhesion can be objectively characterized through the water absorption / waterproof performance of the printing surface. The method comprises the following steps: coating the artificial saliva on the printing surface of a cigarette tipping paper sample according to the specified dosage, absorbing a certain amount of artificial saliva within the specified time, respectively weighing the mass of the cigarette tipping paper before and after surface permeation, and calculating the mass growth percentage of the cigarette tipping paper to obtain the lip adhesion grade of the cigarette tipping paper. The method disclosed by the invention is rapid, simple, convenient and goodin repeatability, can avoid subjective factor influence and difference characterization caused by traditional artificial sensory evaluation, greatly saves the detection cost, and has the advantages in material admission, quality control and product upgrading in the tobacco industry.

The present invention relates to formulations containing phosphoprotein, designed for use as oral lubricant or as artificial saliva, methods of using the formulations and processes for the preparation of the formulations.

The invention discloses a method for measuring lip sticking force of tipping paper for cigarettes. The method comprises the following steps: under the condition of artificial saliva infiltration, enabling the tipping paper for cigarettes to be tightly attached to sample glass fiber paper, testing the color difference value of the sample glass fiber paper and blank glass fiber paper after a periodof time under the condition of load bearing, obtaining the staining fastness level of the sample glass fiber paper, then establishing the quantitative relation between the staining fastness level andthe lip sticking force of the tipping paper for the cigarettes, and then judging the lip sticking force of the tipping paper for the cigarettes. Compared with the result of artificial smoking assessment, the determination method provided by the invention has the advantage that the reproducibility is greatly enhanced.

The invention relates to a device and a method for testing lip adhesion of tipping paper for cigarettes, and belongs to the technical field of analysis and detection. The testing device comprises a stainless steel body and a balance; the bottom surface of the stainless steel body is horizontal, and a through groove is formed in the stainless steel body as an artificial saliva groove; and the axialdirection of the through groove is perpendicular to the horizontal plane. The method comprises the following steps: horizontally placing the stainless steel body on the printing surface of tipping paper, adding a certain amount of artificial saliva, pulling the stainless steel body at a constant speed to enable the longitudinal surface of the tipping paper to be in full contact with and permeatethe adrtificial saliva, respectively weighing the mass before and after the surface of the tipping paper is permeated, calculating the mass growth percentage of the cigarette tipping paper, and then measuring the lip sticking force grade. The device can eliminate errors caused by manual operation, and is good in repeatability and high in precision. The method is rapid, simple and convenient, can avoid subjective factor influence and difference characterization caused by traditional artificial sensory evaluation, greatly saves the detection cost, and has the advantages in material admission, quality control and product upgrading in the tobacco industry.

The invention relates to a method for detecting the lip sticking degree of tipping paper for cigarettes, and belongs to the technical field of analysis and detection. The method comprises the following steps: preparing artificial saliva of which the pH value is 5.5-7.5; transferring 20 [mu]L of artificial saliva, dripping the artificial saliva on a tipping paper printing surface with the area of more than 650mm < 2 >, then performing timing, and performing standing for a period of time; when the stipulated standing time is reached, absorbing excessive liquid on the printing surface of the tipping paper by using absorbent paper, and measuring the infiltration area of the tipping paper infiltrated by the artificial saliva; and judging the lip sticking degree of the tipping paper for the cigarette to be detected according to the artificial saliva infiltration area and the judgment standard. The method disclosed by the invention is rapid, simple, convenient and good in repeatability, can avoid subjective factor influence and difference characterization caused by traditional artificial sensory evaluation, greatly saves the detection cost, and has the advantages in material admission, quality control and product upgrading in the tobacco industry.

The invention discloses a cigarette smoke oral cavity deposition simulation device and method. The device comprises a smoke suction part, a smoke deposition simulation cavity, a smoke capturing part and a suction part which are connected in sequence. The simulation cavity is an interlayer type cylindrical cavity, filter paper coated with artificial saliva is arranged along the inner wall of the cavity, and an interlayer is connected with constant-temperature circulating water; the smoke suction part comprises a three-way valve and a suction pipe, the suction pipe extends into the simulation cavity, the end of the suction pipe is closed, and air holes are evenly distributed in the end of the suction pipe. The device has the characteristics that: 1) the three-way valve is used for controlling the switching between smoking and empty smoking of the cigarette, so that the simulation of smoking, staying and swallowing of smoke in the oral cavity can be realized; 2) the suction pipe port air hole can ensure full diffusion of smoke in the cavity; 3) the cavity volume basically conforms to the oral cavity volume, the filter paper is used for simulating the oral mucosa and adsorbing the smoke in the cavity, the constant-temperature circulating water in the interlayer can simulate the oral cavity temperature; 4) and the trap can realize trapping of swallowing smoke particulate matters after the smoke stays in the oral cavity and is deposited.

The invention relates to a method for rapidly detecting lip sticking of cigarette tipping paper, and belongs to the technical field of analysis and detection. The method comprises the steps of rollingcigarettes by adopting cigarette tipping paper to be detected according to national standards, flatly paving and fixing an artificial mouth skin on a test plate with a certain height, preparing artificial saliva, smearing the artificial saliva on the cigarette tipping paper of a sample to be detected, and immediately sticking the sample to be detected smeared with the artificial saliva onto the artificial mouth skin in a suspending manner; recording the moment when the to-be-detected sample falls off from the artificial mouth skin from the moment when the to-be-detected sample is adhered to the artificial mouth skin; and when the average duration of the plurality of to-be-detected samples from bonding to falling is more than or equal to 3s, determining that the cigarette tipping paper tobe detected has lip sticking force. The method disclosed by the invention is rapid, simple, convenient and good in repeatability, can avoid subjective factor influence and difference characterizationcaused by traditional artificial sensory evaluation, greatly saves the detection cost, and has the advantages in material admission, quality control and product upgrading in the tobacco industry.

The invention relates to the technical field of medical materials, in particular to a high-wear-resistance composite material for preparing porcelain teeth and a preparation method of the high-wear-resistance composite material. The high-wear-resistance composite material is prepared from the following raw materials in parts by weight: 20 to 30 parts of metal oxygen compound, 8 to 15 parts of metal nitride whisker, 18 to 30 parts of titanium dioxide, 10 to 30 parts of silicon dioxide, 30 to 40 parts of zirconium dioxide, 5 to 8 parts of silver preparation, 120 to 160 parts of 80% ethanol and 50 to 70 parts of deionized water. The titanium dioxide modified by the titanate coupling agent is added, so that the corrosive wear of the artificial saliva to the porcelain tooth material can be slowed down to a certain extent, and the life cycle of the porcelain tooth is prolonged; the silane coupling agent modified zirconium dioxide is added, so that the mechanical property of the porcelain tooth material can be enhanced, and the porcelain tooth material can meet the use requirements of people in daily life.

The invention provides a composition for promoting tooth mineralization and application thereof, and belongs to the field of daily chemical products. The composition for promoting tooth mineralization is prepared from the following raw materials in parts by weight: 15 to 25 parts of hydrated silica, 2 to 5 parts of calcium sodium phosphate silicate, 0.1 to 0.5 part of titanium dioxide and 0.1 to 0.5 part of lithium magnesium phosphate. After the composition is treated by artificial saliva, mineralization can occur in dentinal tubules, needle-like hydroxyapatite is formed on the surfaces of particles, and uniform support is formed for the dentinal tubules, so that tissue mineralization is achieved, a bone protective film is formed for enamel wrapping, tooth holes are filled, and the problem of tooth sensitivity is quickly solved.

The invention relates to artificial saliva, which comprises a plurality of inorganic salt, HPMC, a preservative, a flavoring agent and other components. The artificial saliva has the following advantages that: (1) the artificial saliva can rapidly improve symptoms of a patient suffering from xerostomia, and can maintain the function in a longer period; (2) the artificial saliva has good stability; and (3) the artificial saliva has a good mouthfeel when in use.

The invention relates to a method for detecting a release situation of nicotine in buccal tobacco products, which is characterized by comprising the steps of simulating the release situation of the nicotine in the buccal tobacco products in the human mouth, instantly quantifying the release quantity and the release speed and then detecting the release speed and the release degree of the nicotine in the buccal tobacco products. The release and the collection of the nicotine are realized through a release and collection device in vitro; by means of the device, the release process of the nicotine in the buccal tobacco products in the human mouth can be simulated and nicotine release solutions can be the instantly collected, wherein the release process is a process that the nicotine is continuously extracted from the buccal tobacco products by utilizing artificial saliva at a constant temperature; and the detection of the nicotine content in the release solution is realized through a highperformance liquid chromatography. The method has the advantages: the release speed and the release degree of the nicotine in various buccal tobacco products can be rapidly and accurately detected with good repeatability, high sensitivity and short detection period and is suitable for the rapid analysis of mass samples for different industries and different purposes.

The invention relates to a method for quickly detecting whether cigarette tipping paper sticks to lips, and belongs to the technical field of analysis and detection. According to the national standard, the cigarette tipping paper to be tested is used to roll cigarettes, the artificial mouth skin is flatly fixed on a test board of a certain height, artificial saliva is prepared, and the artificial saliva is applied to the tipping paper of the cigarette to be tested. , and then immediately paste the sample to be tested coated with artificial saliva on the artificial mouth skin in a suspended manner; counting from the time when the sample to be tested is pasted on the artificial mouth skin, record the moment when the sample to be tested falls from the artificial mouth skin; If the average time between sticking and falling of the sample to be tested is ≥3s, the tipping paper of the cigarette to be tested has lip sticking force. The method of the present invention is fast, simple, and has good repeatability, which can avoid the influence of subjective factors and differential characterization brought about by the traditional artificial sensory evaluation, and greatly saves the detection cost. There are advantages in the product.

The invention discloses a simulated oral cavity device for studying the release law of snus components and its use method, which includes an automatic injection pump, a plurality of syringes, a syringe jacket, a test tube and a constant temperature water bath, and the plurality of syringes are arranged on the automatic injection pump. The artificial saliva is inhaled into the syringe and connected to the syringe jacket through the catheter, the mouth smoke is placed in the syringe jacket, the syringe jacket is placed in the test tube in the constant temperature water bath and there is a gap with the bottom of the test tube; the bottom of the syringe jacket Leave an opening. The device and its use method can simultaneously collect the eluate of different or the same types of snus samples through multiple channels. After connecting multiple syringes to the automatic syringe pump, and then connecting a catheter to each syringe, it can be realized. Multiple snus samples were supplied with artificial saliva accurately, uniformly and quantitatively at the same time, and the eluate of different time periods was collected at any time.

The invention discloses an oral care composition for treating xerostomia and the application of the oral care composition. The oral care composition consists of the following components in parts by weight: 0.1-1.5 parts of an olive extract, 0.1-1 part of lactoferrin microspheres and 0.1-5 parts of zinc oxide microspheres. The oral care composition can stimulate saliva secretion, relieve xerostomia, treat gingivitis and alleviate halitosis, can also achieve the effect of artificial saliva, realizes the effect of sterilizing the mouth, facilitates oral health of patients with xerostomia, and can be used for preparing oral care products for treating xerostomia and complication thereof.