20 results about "Artificial salivas" patented technology

The utility model belongs to the technical field of dental prosthesis design, and particularly discloses a hollow base liquid storage type removable denture which comprises a base and artificial teeth arranged on the base, the base is a hollow base with a liquid storage cavity, the hollow base is provided with a plurality of overflow discharge channels communicated with the liquid storage cavity, and the diameter of the outlet end of each overflow discharge channel is 0.3-1mm; a plurality of tissue surface adsorption structures are arranged on the tissue surface part of the base plate. The removable denture disclosed by the utility model can automatically and slowly release artificial saliva, so that the dry feeling of an oral cavity is reduced; due to the design of the tissue surface adsorption structure on the tissue surface, the contact area between the base plate and the oral cavity tissue is increased, so that the adsorption force is improved.

The invention discloses a synthetic cannabinoid nucleic acid aptamer and application thereof. The synthetic cannabinoid nucleic acid aptamer is shown as any one of nucleotide sequences SEQ ID NO.1-8. The invention further discloses a synthetic cannabinoid nucleic acid aptamer. According to the invention, a plurality of synthetic cannabinoid structures are taken as positive screening targets, a plurality of non-synthetic cannabinoid structures are taken as negative screening targets, and a plurality of nucleic acid aptamers with high affinity to the plurality of synthetic cannabinoid structures are screened based on a ligands index enrichment system evolution technology; the functional motif combined with the synthesized cannabinoid indazole-3-formamide framework structure is found for the first time. Through verification, the KD value of the aptamer and the inspected synthetic cannabinoid is 0.1-1.3 [mu] M, the detection linear range of ADB-PHETINACA in 50% artificial saliva by a fluorescent dye replacement detection method based on the aptamer is 20-400 ng / mL, the detection limit is 2.1 ng / mL, the sensitivity is high, the detection is rapid, the operation is simple and convenient, and the fluorescent dye replacement detection method can be used for rapid drug screening.

The utility model relates to dental instrument test technical field especially, it relates to a kind of anti-bruxism sleeve endurance test tooling. Including: occlusion controller, configuration is to exert set pressure and carry out set number of occlusion cycle, the occlusion cycle includes loading and unloading operation;Test sink, for containing artificial saliva and immerging to be measured anti-bruxism sleeve;Temperature controller, for the artificial saliva is heated and maintained at set temperature;Tooth model, for fixing the anti-bruxism sleeve, and place in the test sink;Wherein, the occlusion controller includes pressure applying device, for the anti-bruxism sleeve fixed on the tooth model is exerted vertical occlusal force, to simulate human occlusion action.By multiple components cooperation realizes accurate simulation oral environment, occlusion action to test the use effect of anti-bruxism sleeve.

The invention discloses artificial saliva and a preparation method of artificial saliva hydrogel. The artificial saliva is prepared from the following raw materials in parts by mass: 0.5 to 1 g of KCl, 0.2 to 0.4 g of K2HPO4, 0.2 to 0.8 g of NaCl, 0.2 to 0.4 g of KH2P O4, 10.04 to 20.8 g of CaCl2, 1.5 to 3 g of Nacaboxymethlecellulose, 60 to 120 mg of brown moss alcohol, 495 to 1000 ml of natural coconut juice and 5 to 10 ml of herba sarcandrae extract. By selecting the glabrous sarcandra herb extract, anti-inflammatory and anti-tumor treatment is realized, so that the traditional Chinese medicine composition has a remarkable effect on dry mouth caused by radiotherapy; through the form of a gel bead preparation, the beverage is more portable and unique in taste. The gel beads serve as one of oral local administration preparations, and after the gel beads are exploded, drugs can target small glands which are located below oral mucosa and secrete saliva, and the rapid drug effect is achieved. Direct local administration to the oral mucosa may provide rapid drug action, activate small salivary glands within the buccal mucosa, while avoiding systemic drug exposure and off-target effect.

The invention provides an artificial saliva spray. The artificial saliva spray is prepared from the following components in percentage by mass: 0.001 to 0.003 percent of hydrogenated castor oil, 0.02 to 0.07 percent of xanthan gum, 0.01 to 0.03 percent of cyclodextrin, 0.01 to 0.02 percent of calcium chloride, 0.01 to 0.05 percent of dipotassium phosphate, 0.1 to 0.15 percent of potassium chloride, 0.05 to 0.1 percent of sodium chloride, 0.004 to 0.006 percent of magnesium chloride and the balance of water. The artificial saliva suitable for the spray is provided, the dosage is accurate, the good oral cavity adhesion capacity is achieved, and the effect maintaining time is long.

The invention belongs to the technical field of orthodontic medical instruments, and particularly relates to a miniature tubular anterior tooth orthodontic bracket and an orthodontic method thereof.The bracket body is of a hollow circular tubular structure, the tooth attaching end is of a continuous smooth cylindrical surface design and is in linear contact fit with the tooth surface, and the protruding height after adhesion is smaller than or equal to 2 mm; the roughness Ra of the inner wall of the internal force application channel is 0.15-0.25 mu m; the main body is formed by integral compression molding of a medical composite material containing bismuth oxide; the technical prejudice that bonding is unstable and non-metallic materials cannot be developed due to line contact is broken through, and the excellent performance that the X-ray development definition is greatly improved, the shear bonding strength is 18.5 + / -1.2 MPa, the hardness retention rate is larger than or equal to 90% after artificial saliva soaking for 180 days, and the mucous membrane compression pain occurrence rate is reduced is achieved; the single bracket can independently complete the anterior tooth local deformity correction function without being matched with a full-mouth bracket system, the anterior tooth gap closing period is averagely shortened, and the social concealment, the clinical operation efficiency and the patient comfort are remarkably improved.

The invention belongs to the technical field of cigarette tipping paper taste substance analysis, and particularly relates to a bionic simulation collection device and an analysis method for the dynamic migration quantity of taste substances in taste tipping paper. The bionic simulation collection device comprises a simulation lip, a simulation oral cavity, a smoke collector and a smoke suction machine which are sequentially communicated from upstream to downstream. The analysis method comprises the following steps: S1, connecting an artificial lip and a simulated oral cavity with a smoking machine, and infiltrating with artificial saliva; s2, the taste tipping paper of the cigarette is fixed to an artificial lip, the surface of the artificial lip is attached to the surface of a filter tip, and in the smoking interval process, the cigarette is inserted and pulled out; s3, after smoking is finished, the artificial lip cleaning fluid and the simulated oral cavity cleaning fluid are collected, and the migration amount of the taste substances is detected. The method is closer to the actual cigarette smoking process, and powerful technical support can be provided for cigarette product research and development, smoke physiological feeling, smoking, health and other basic research.

A dentifrice composition includes, based on 100 wt% of the dentifrice composition, from 0.1 wt% to 30 wt% of a bioactive glass composition, from 1 wt% to 40 wt% of at least one amino acid, and from 0.1 wt% to 30 wt% of an abrasive. The dentifrice composition can be fluorine-free. The dentifrice composition can produce hydroxyapatite by 24 hours in an Artificial Saliva Test. The bioactive glass composition can include, based on 100 wt% of the bioactive glass composition, from 15 wt% to 45 wt% SiO2, from 8 wt% to 30 wt% P2O5, from 32 wt% to 60 wt% CaO, and from 1 wt% to 15 wt% ZrO2.

The present invention discloses an orthodontic archwire friction corrosion testing device and testing method. The device includes: an electrochemical corrosion testing assembly for placing an archwire and containing artificial saliva, immersing the archwire in the artificial saliva, and performing electrochemical testing on the archwire in the artificial saliva to output a corresponding corrosion test signal; a friction and wear testing assembly, corresponding to the electrochemical corrosion testing assembly, for fixing brackets and performing friction testing on the brackets and archwire to output a corresponding friction test signal; and a data acquisition and calculation assembly, wherein the acquisition end of the data acquisition and calculation assembly is connected to the output end of the friction and wear testing assembly and the output end of the electrochemical corrosion testing assembly, respectively, and the data acquisition and calculation assembly is used to collect friction test signals and corrosion test signals and calculate the friction parameters and corrosion parameters of the archwire. The present invention aims to enable the testing device to complete simultaneous testing of the friction, wear and corrosion properties of the archwire in an artificial saliva environment.

The invention discloses a biomimetic fluid-based medical equipment phthalate migration test method, which is characterized by comprising the following steps: (1) taking artificial saliva as a leaching solution; the method comprises the following steps: soaking a to-be-detected medical equipment pipeline sample in a glassware according to the ratio of the sum of the internal area and the external area (cm < 2 >) to the volume (mL) of a leaching solution of 2: 1, and standing for 24 hours at the constant temperature of 37 + / -1 DEG C; (2) transferring a proper amount of the extract liquid into a test tube, then adding n-hexane, fully oscillating for 10 minutes, then centrifuging, sucking an upper-layer n-hexane solution by using a glass dropper, and extracting by using a solid-phase extraction column to obtain an extracting solution; repeating the extraction step twice; (3) mixing the three extracting solutions, evaporating the mixed extracting solutions in a vacuum rotary evaporator until the mixed extracting solutions are nearly dry, and then adding n-hexane to dissolve the mixed extracting solutions to obtain a detection solution; and analyzing the detection liquid by using a gas chromatograph-mass spectrometer, and testing the migration volume of the phthalate.

The invention belongs to the field of new medical materials, and discloses a method for repairing a subfissure tooth sample and a device for repairing subfissure teeth in an oral cavity, the method comprises the following steps: placing the subfissure tooth sample in an ALD reaction chamber, and vacuumizing; introducing a gaseous titanium precursor titanium tetraisopropylate, carrying out single-layer reaction on the subfissure tooth sample to form a Ti-O bond, and completing a first deposition half cycle; introducing inert gas to purge the reaction chamber; introducing an oxygen source to form a TiO2 film, and completing a second deposition half cycle; repeating the first deposition half cycle and the second deposition half cycle for multiple times until the TiO2 film grows on the subfissure tooth sample; and soaking the subfissure tooth sample subjected to ALD treatment in artificial saliva, and inducing remineralization by using a TiO2 film to form a mineralizer. According to the device and the method disclosed by the invention, the precise repair of the subfissure tooth or the in-vitro subfissure tooth sample can be realized, and the occurrence risk of pulpitis, apicitis and other bacterial infectious diseases in the oral cavity can also be reduced.

The invention provides a dental caries biofilm model construction method and application thereof, and belongs to the technical field of model preparation. The invention relates to a dental caries biomembrane model construction method, which comprises: pre-culturing a matrix in artificial saliva to obtain a matrix with an acquired membrane formed on the surface; the method comprises the following steps: carrying out in-vitro cariogenic culture on a tooth surface microorganism sample of a healthy crowd in a cariogenic culture solution to obtain a culture environment containing cariogenic microorganisms; and placing the matrix with the acquired membrane formed on the surface in a culture environment containing cariogenic microorganisms for cariogenic culture, and regularly replacing fresh cariogenic culture solution during the period to obtain a matrix loaded with a cariogenic biological membrane, namely the caries biological membrane model. The dental caries biofilm model provided by the invention can simulate complex ecological and pathogenic mechanisms of a biofilm on the surface of a real tooth, and is suitable for efficacy evaluation of anti-dental caries drugs and oral care products.

The invention belongs to the technical field of tobacco detection, and particularly relates to a device and a method for measuring the migration volume of an antibacterial agent in antibacterial tipping paper. The measuring device comprises an artificial lip, a simulated lip membrane, a flue gas collector and a smoking machine which are sequentially communicated from upstream to downstream. The determination method comprises the following steps: infiltrating the artificial lip and the simulated lip membrane with artificial saliva; the antibacterial tipping paper of the cigarette is fixed on the artificial lip through the cigarette holder, the simulated lip film is pressed close to the antibacterial tipping paper on the surface of a filter tip through up-down closing of the artificial lip, and the cigarette is inserted and pulled out in the smoking interval process; after smoking is finished, the migration antibacterial agent on the artificial lips and the simulated lip membrane is collected, and the migration amount of the antibacterial agent is detected. According to the method, contact and migration bionic simulation of the antibacterial tipping paper is carried out through the device, the method is consistent with the actual smoking process of cigarettes, and an effective evaluation tool and a technical method can be provided for fundamental researches such as research and development of cigarette products and safety evaluation of the cigarette tipping paper.

The present application relates to the technical field of oral products, and specifically discloses a manganese tungstate nanoparticle / hydrogen peroxide composition for tooth whitening and a preparation method thereof. The preparation method comprises the following steps: preparing manganese tungstate nanoparticles, dispersing tungsten hexacarbonyl and a surfactant in a first organic solvent, adding an oleic acid / oleylamine ligand pair under first reaction conditions, then stirring and reacting under second reaction conditions, cooling, centrifuging, washing, and drying to obtain the manganese tungstate nanoparticles. The manganese tungstate nanoparticles / polyethylene glycol composite material is prepared by dispersing the manganese tungstate nanoparticles and a polyethylene glycol derivative in a second organic solvent, uniformly stirring, and nitrogen drying. The manganese tungstate nanoparticle / polyethylene glycol composite material is dissolved in artificial saliva, hydrogen peroxide solution is added and mixed to obtain the manganese tungstate nanoparticle / hydrogen peroxide composition for tooth whitening.

The invention discloses a method for efficiently producing volatile fatty acid by anaerobic fermentation of white spirit vinasse based on rumen microorganisms, which comprises the following steps: S1, substrate pretreatment: selecting white spirit vinasse as a fermentation substrate, and sequentially drying and crushing the fermentation substrate to obtain a pretreated substrate; s2, construction of an inoculation system: taking fresh rumen fluid as an inoculation source, mixing the fresh rumen fluid with an artificial saliva culture medium and a pretreatment substrate, adjusting the concentration of the substrate to 2-5% (w / v), and constructing a fermentation system; s3, anaerobic fermentation: placing the fermentation system in an anaerobic environment, culturing at 37-40 DEG C for 3-7 days, and maintaining the pH value of the fermentation system at 5.5-6.0 in the culture process. According to the method, efficient hydrolysis and conversion of the Baijiu vinasse are achieved, and the total yield of volatile fatty acid is remarkably increased.

The invention provides a cigarette smoke oral cavity simulation absorption device and an absorption method. The absorption device comprises an oral cavity simulation device, a cigarette holder, a smoke trapping device, a suction passage, a smoke exhaust passage, a passage switching device and a sphere compression and relaxation device, the oral cavity simulation device comprises an elastic hollow sphere which contains artificial saliva and is provided with an open end; one end of the smoking passage is connected with the cigarette holder, and the other end is connected with the open end; one end of the smoke exhaust passage is connected with the open end, and the other end is connected with the smoke trapping device; the passage switching device is arranged on the suction passage and the smoke exhaust passage and is used for switching a suction state and a smoke exhaust state; the ball body compression and relaxation device is connected with the outer wall of the elastic hollow ball body to periodically compress and relax the elastic hollow ball body, so that physiological actions of the oral cavity of a human body during cigarette smoking can be more vividly simulated, and more accurate experimental data can be obtained; a reliable data basis is provided for quantitatively researching the deposition of the cigarette mainstream smoke in the oral cavity of a human body.

This invention belongs to the field of oral health protection and rehabilitation technology, and particularly relates to a multifunctional oral support device and its usage method. The device assists patients in opening their mouths during treatment. An angle sensor allows for real-time acquisition of the patient's mouth opening degree, preventing excessive mouth opening that could cause discomfort or injury, and protecting the temporomandibular joint. A radiation protection component shields some radiation, reducing damage to adjacent organs outside the radiotherapy target area. An atomization component finely atomizes artificial saliva or topical epidermal growth factor and sprays it into the patient's oral cavity and deep oropharynx, alleviating dry mouth and mucosal damage. During rehabilitation training, the first and second sensing components allow for real-time monitoring of the patient's oral condition, enabling timely adjustments to the rehabilitation method.

The invention provides a method and equipment for evaluating the dissolution behavior of active ingredients in an oral product. The method comprises the following steps: placing the oral product in a sample chamber; conveying the artificial saliva into the sample chamber, so that the artificial saliva is in contact with the oral product, and active ingredients of the oral product are dissolved in the artificial saliva to form a dissolution solution; detecting the contents of the active components in the dissolution liquid at different time through liquid chromatography to obtain dissolution data of a plurality of groups of active components; and evaluating the dissolution behavior of the oral product according to the multiple groups of dissolution data and a preset similarity factor calculation formula. The active components in the oral product are detected and separated through liquid chromatography and are not easily interfered by other impurity components in the oral product, and the detection efficiency is high. And the evaluation equipment is assembled by only using conventional experimental apparatuses without using flow cell equipment, so that the operation is simple, and the detection time is shortened. Finally, the evaluation method has good discrimination and reproducibility in the detection process, and can stably distinguish the active ingredient dissolution behaviors of the oral products from different manufacturers.

The utility model belongs to the technical field of analysis and detection equipment discloses a kind of cigarette tipping paper stick lip property testing device, including datum plate, smearing mechanism and measuring assembly. When the stick lip property of cigarette tipping paper surface that smears artificial saliva is measured, first, cigarette tipping paper is placed on datum plane, then artificial saliva is smeared on cigarette tipping paper surface by smearing mechanism, and then measuring piece is released from the top end of sliding slot without initial speed, so that measuring piece moves from the top end of sliding slot to cigarette tipping paper along sliding slot under the action of gravity, and the distance of measuring piece moving on cigarette tipping paper is read by scale line. When the stick lip property of cigarette tipping paper surface that does not smear artificial saliva is measured, artificial saliva does not need to be smeared on cigarette tipping paper surface by smearing mechanism. Smearing artificial saliva on cigarette tipping paper surface by smearing mechanism can accurately control the smearing amount of artificial saliva, make smearing more uniform, reduce measurement error, and improve the accuracy of measurement result.

The present invention provides a tongue training device and a method for using the same. The device includes a front occlusal portion and a rear fixing portion; the front occlusal portion and the rear fixing portion are detachably connected; an elastic telescopic layer is provided in the middle of the rear fixing portion; an elastic telescopic column is provided in the elastic telescopic layer; a tooth socket is also provided at the connection between the front occlusal portion and the rear fixing portion; a conical groove is provided in the middle of the front occlusal portion; the conical groove matches the conical shape of the front end of the elastic telescopic layer. The present invention realizes the functions of combining mouth opening training, tongue function training and stimulating autonomous saliva secretion through a tongue training device, and can encourage patients to perform mouth opening training while performing tongue function exercises, and as the upper and lower jaws and tongue move, the muscles in the oral cavity are driven to move, thereby promoting the device containing the stimulation liquid in the device to automatically secrete artificial saliva, thereby achieving the purpose of bionics, improving the patient's oral environment, and promoting the recovery of treatment complications such as difficulty opening the mouth, speech disorders, dysphagia, and taste disorders. This improves the quality of life of patients.