81 results about "Physiological actions" patented technology

The invention provides a preparation method and application technique of Chinese herbal medicine preservative for vegetables, especially a preserving method of stalk vegetables such as wormwood at normal-temperature condition, comprising a concrete composition of Chinese herbal medicine preservative and application method. The Chinese herbal medicine preservative comprises a Chinese herbal medicine extracting solution, a film-forming agent and a solvent. The growth of the microbe on the surface of the stalk vegetables such as wormwood is inhibited using the sterilization and antiseptic action of the Chinese herbal medicine extracting solution, at the same time a layer of film is formed on the surface of the vegetable using the film-forming agent and the vegetables respiration and other physiological action are reduced, therefore the shelf life can be prolonged and the storage period of stalk vegetables such as wormwood can be prolonged to above two times than the prior technique.

The invention provides a small peptide additive for porcine feed and a preparation method thereof; the small peptide additive for porcine feed is characterized in that the additive is prepared by mixing base materials, saccharomyces cerevisiae liquid, lactobacillus acidophilus liquid, bacillus subtilis liquid and water according to a weight ratio of 100:3-4:3-4:5-7:35-4, and performing solid fermentation; the base materials comprise 50-70 wt% of soybean meal, 4-5 wt% of rapeseed meal, 10-15 wt% of fish meal, 5-8 wt% of vinasse, 2-5 wt% of corn starch, 1-3 wt% of wheat bran, 1-3 wt% of molasses, 1-3 wt% of yellow mealworm, and 0.5-1 wt% of sodium carbonate. The small peptide additive for porcine feed of the invention can increase the synthesis speed of protein for pig body, promote food ingestion of pigs, increase appetite, improve immunity, promote the absorption of mineral elements by pig body, regulate various physiological actions of the body, reduce stress, and improve the nutritional status of pig body.

The invention provides a phellinus igniarius juice health-care food and a preparation method thereof. The preparation method comprises the following steps of firstly, preparing a liquid fermentation medium; secondly, performing liquid fermentation on a phellinus igniarius strain; thirdly, collecting fermentation liquor obtained by fermenting phellinus igniarius liquid, and performing clarification or homogenization treatment on the fermentation liquor; fourthly, performing sterilizing, filling or spray drying treatment on the clarified or homogenized fermentation liquor. According to the phellinus igniarius juice health-care food and the preparation method thereof provided by the invention, juice is utilized to directly serve as a carbon source for fermenting phellinus igniarius, and nutritional ingredients and health-care ingredients obtained by fermenting the phellinus igniarius directly infiltrate into the juice to prepare the healthy food with the function of enhancing the physiological actions such as immunity and the like. The phellinus igniarius juice health-care food and the preparation method thereof have the advantages of simple technical operation, safety, reliability and suitability for industrialized large-scale production.

The invention relates to a fluorescence probe, and particularly relates to a cyanin-based organic compound and an application thereof. A structural formula of the cyanin-based organic compound is as shown in the formula I in the specification. According to the compound serving as a cysteine fluorescent probe, the corresponding fluorescence intensity obviously changes under the existence of cysteine, the compound can be applied to cysteine detection, the interference of an external detection condition can be greatly reduced, and the detection accuracy is improved. According to the compound serving as the cysteine fluorescent probe, ultraviolet absorption obviously changes under the existence of cysteine, and the compound serving as the cysteine fluorescent probe can be simultaneously used for detection by using an ultraviolet spectrophotometer and naked eyes. The compound can be applied to detection of cysteine levels inside and outside a cell as the fluorescent probe, and the compound has important biomedical significance on intensive study of dynamics mechanism of the processes of cysteine generation, transportation and accumulation inside a living body, particularly study of physiological action of cysteine in mitochondria.

The invention relates to functional edible oil containing lycoypene. According to the invention, plant edible oil contains lycoypene and vitamin E. The invention is characterized in that 100g of the plant edible oil contains 12-200mg of lycoypene and 2-20mg of vitamin E, the lycoypene and the plant edible oil form a uniform and clear mixture, and precipitation capacity of the lycoypene is not more than 5 percent after the functional edible oil stands still for 120-168 hours. The function edible oil does not contain chemical antioxidants and has natural oxidation resistance. On the basis of research on the property and function of lycoypene, a proper amount of lycoypene is added to plant edible oil and can be ingested by people through cooking, the physiological action of lycoypene can be fully played, and the functional edible oil has health-care and treatment effects.

The invention discloses a building method of a two-level fitting quantitative structure-activity relationship (QSAR) model for forecasting compound activity. The building method includes following procedures: 1 a plurality of compounds with the same frames are utilized as a training set, and the train set compounds are divided into substituent groups and are coincided; 2 a linear regression method is utilized to calculate local physiological action produced by each substituent group, and a preceding-stage fitting model is built; 3 according to the local physiological action which is obtained in calculating mode in the procedure 2, a neural network method is utilized to calculate the whole biological activity, and a backward-stage fitting model is built; and 4 the preceding-stage fitting model and the backward-stage fitting model are combined to form the front-and-back two-stage QSAR model. According to the building method, the linear regression method and the neural network method are combined to build the model, the neural network method has good fitting performance, and compared with a traditional linear model, the built model can accurately forecast the biological activity of the compounds.

The present invention provides a recombinant glandular related virus capable of expressing human kallikrein, its preparation method and application, and medicine composition containing said recombinant glandular related virus. Said recombinant glandular related virus can drive the human kallikrein gene to make long-period expression in human body, and possesses good physiological and pathologic physiological action for effectively reducing blood pressure, improving renal function and preventing apoplexy, and can be used for clinical curing the above-mentioned diseases.

The invention provides an enhanced type fluorescent probe for detecting hydrogen sulfide. The fluorescent probe is an NRS fluorescent probe, the structural general formula of the NRS fluorescent probe is shown as (I), the preparation method comprises the following steps: adding nile red, 2,4-dinitrofluorobenzene and potassium carbonate into dimethylformamide, heating to 70-80DEG C, performing reflux reaction for 3 hours, extracting the reaction liquor by dichloromethane and collecting an organic phase, drying the organic phase with anhydrous magnesium sulfate, and purifying through silica column chromatography to obtain a target product. The probe has a mitochondrial location function, can perform real-time and on-site online detection to mitochondria, and can help us to further master the physiological function of the hydrogen sulfide and promote the understanding of physiological action of H2S, and provide a visible detection tool for research and development of novel cardiovascular drugs.

The invention relates to biochemical treatment technology for unneutralized furfural wastewater. The furfural wastewater enters into an emergency reservoir first; partial furfural wastewater produced during production of furfural each day enters into a regulating reservoir, and the other part of the furfural wastewater enters into the emergency reservoir; the furfural wastewater in the emergency reservoir is extracted and pumped into the regulating reservoir by a temperature adjusting pump, and the temperature of the furfural wastewater in the regulating reservoir is adjusted to be between 35 and 40 DEG C; the furfural wastewater is lifted by a sewage pump into an anaerobic sequencing-batch reactor, and is fully mixed with anaerobe; a large part of organic pollutant is decomposed into methane and water under the physiological action of the anaerobe; when the pH of a solution in the anaerobic sequencing-batch reactor is raised to be between 7.0 and 7.2, operation of a circulating pump and a pulse feeder is stopped for entering into a precipitation stage; after precipitation, the water flows into an intermediate reservoir through a siphonic decanting drainer; and the wastewater in the intermediate reservoir is lifted by an intake pump of a sequencing-batch activated sludge process, enters into a reservoir of the sequencing-batch activated sludge process according to operation rules of the sequencing-batch activated sludge process, is purified, enters into a clean water reservoir, is subjected to strong oxidation treatment of ozone, and is released after reaching the standard.

The invention discloses a method for producing and preparing a selenium-enriched chicken feed through yeast fermentation. The method comprises the following steps of performing inoculating with yeaston a culture solution with sodium selenite for domesticizing, screening out selenium-enriched yeast strains, using selenium-enriched peanut shells, stalks and selenium-enriched corn as main raw materials of a fermentation substrate, and performing fermentation production of the selenium-enriched feed. Through the physiological action of the strains, the process of converting inorganic selenium inthe raw materials of the feed into organic selenium is promoted, and absorption of selenium by chicken bodies is facilitated, so that the enrichment of the selenium in the chicken bodies is promoted,the immunity of animals is improved, and the economic benefits are increased; and besides, through aerobic-anaerobic fermentation treatment, the fermentation efficiency is improved, the palatability of the feed is improved, high absorption rate of a selenium yeast feed by the chicken bodies is guaranteed, and daily feed nutrients are supplemented and improved.

The invention discloses a composite anti-aging composition containing a plant extract and application thereof. An effective component of the anti-aging composition is formed by compounding hyalurate,polypeptide and an anti-aging plant extract. The anti-aging composition simultaneously contains the hyalurate, the polypeptide and the anti-aging plant extract in 3 types of molecular weights. The three parties can achieve the effect together under the skin physiological action of hydration, a barrier function, oxidation and inflammation and the like, have coordinated synergism, and are capable ofachieving the good anti-aging effect. In addition, the anti-aging composition is simple in component type, easy to prepare, and easy to be mixed in cosmetics with other components, and has the apparent advantage of being capable being easily added into various types of formulas.

The invention discloses a fusion protein containing glicetin-1 (GLP-1) as well as a preparation method and application. The fusion protein has the amino acid sequence shown in SEQ ID NO.1. According to the invention, an amino acid with known sequence is mutated by a gene engineering method to obtain the nucleotide sequence encoding the fusion protein provided by the invention, then the nucleotide sequence is cloned to an expression carrier, and expression and purification are carried out to obtain the fusion protein. By adopting the fusion protein containing GLP-1, the GLP-1 has better stability and duration in physiological action; furthermore, pharmacodynamic result shows that the fusion protein has significant effect of reducing blood sugar; and in addition, by long-term injection of the fusion protein, the sugar tolerance is significantly improved, the insulin secretion is stimulated, pancreatic island beta cells are protected and the development of the diabetes course is delayed. Therefore, the GLP-1 fusion protein has extraordinary advantages and potential to be applied to clinical treatment.

The invention relates to a spinous process and vertebral plate stabilizer, and belongs to the technical field of an elastomer for vertebral plate dynamic fixation. The spinous process and vertebral plate stabilizer includes a first fixing portion, a second fixing portion, and an elastic device; the first fixing portion is connected to the second fixing portion through the elastic device; a first fixing portion is of a clamp-shaped structure formed by two side wings a and a bottom plate; the second fixing portion is of a clamp-shaped structure formed by two side wings b and an arc bottom plate; and the elastic device consists of a first elastic structure, a second elastic structure and a third elastic structure. The spinous process and vertebral plate stabilizer fully considers the demands of physiological actions of a human body, can achieve maximum matching with the activity in all the directions, is reasonable in structure, is strong in vertical support force, is small in size, is reliable in fixation, and is high in elasticity attenuation resistance ability and can be used for the human body in a long term; rotation centers of a coronal view and a sagittal view of a prosthesis are close to rotation centers of a coronal view and a sagittal view of a spine of the human body after the stabilizer is implanted; and the spinous process and vertebral plate stabilizer is conductive to postoperative recovery of a patient, is easy to operate, and can lower the difficulty and risks of an operation.

The invention discloses a making method of blood replenishing and qi regulating health care nutrient drinks, belonging to the technical field of special purpose drinks. The making method comprises the following steps of: 1, carrying out superfine grinding, carrying out ultrasonic water leaching of effective components, ultra-filtering to respectively obtaining extracting solutions of dangshen, fleece-flower root and Chinese angelica; 2, mixing the following components in parts by weight: 1.9-2.1 parts of dangshen extracting solution, 1.9-2.1 parts of fleece-flower root, 0.9-1.1 parts of Chinese angelica, 0.038-0.040 part of vitamin C, 0.011-0.013 part of iron lactate and 0.009-0.011 part of citric acid; and 3, adding brown sugar and water to be blended to obtain a blending solution, ultra-filtering the blending solution by using an ultra-filtering device, carrying out sterile cold filling by using a sterile cold filing device, and finally, carrying out ultra-high temperature instant sterilization by using an ultra-high temperature instant sterilization device. The blood replenishing and qi regulating health care nutrient drinks have important physiological functions of replenishing blood, regulating qi, promoting secretion of saliva or body fluid, and enhancing organism immunity, are especially suitable for puerperae suffering from weakness, qi deficiency and ischemia, and also has physiological actions of resisting oxidization, eliminating toxicant and nourishing skin, delaying ageing and the like.

The invention belongs to the technical field of biology, and specifically discloses a targeting vector for pig GHR gene knock-out and applications thereof. The targeting vector is a sgRNA expression vector based on a CRISPR/Cas system; wherein the target sequences of sgRNA are arranged on the 10th exon and 3'UTR of a pig GHR gene. The provided targeting vector is applied to targeting knock-out ofpig GHR gene, and the knock-out efficiency can reach 12.7%. After the GHR gene is successfully knocked out, somatic cells can be used to establish a GHR gene knock-out pig model by a somatic cell nuclear transplanting technology, and materials are provided for the research of physiological action and molecular mechanism of GHR gene.

The invention relates to a compound preparation for reducing blood sugar and belongs to the technical field of oral preparation. The product is characterized in that the compound preparation is prepared from the following traditional Chinese medicine materials in weight portion: 5 to 25 portions of polygonatum, 5 to 25 portions of herba lophatheri and 3 to 12 portions of balsam pear. Oral liquid is the preferred preparation form; and the compound preparation can also be prepared into different preparation forms. The product has a refined formula, can effectively reduce blood sugar of diabetic patients without causing hypoglycemia reaction, has prevention function, and is mainly used for diabetic prevention and treatment. A safety test, a pharmacodynamic test, an acute toxicity test and a clinical test prove that the product can improve the activity of insulin and reduce the production of mutant insulin so that the product realizes physiological action with higher efficiency, promotes the ingestion and utilization of glucose by tissues and cells, and balances the energy metabolism of organism, thereby removing the symptoms of the diabetic patients. The product has remarkable effect, stability, safety, no toxicity, no side effect and can be taken for a long time.

A topical liposomal base delivery agent for physiologically enhancing muscle efficiency and relaxation, which combines the physiological effects of guaifenesin, magnesium, and methylsulfonylmethane. The resulting physiological reaction reduces muscle and joint soreness in the host. The present invention is an improvement over existing methods that deliver magnesium to muscle tissue.

Provided are methods for treating a mammal undergoing sepsis, or at risk for sepsis. Also provided are methods of preventing or treating a physiological effect of sepsis in a mammal. Additionally provided are methods of inhibiting an inflammatory response in a mammal. Further provided is the use of an α_2A-adrenergic antagonist for the manufacture of a medicament for preventing or treating a physiologic effect of sepsis in a mammal, and the use of an α_2A-adrenergic antagonist for the treatment of a mammal having sepsis or at risk for sepsis.

The invention discloses chitosan gelatin having physiological response properties and an application of the chitosan gelatin to prevention adhesion in uterine cavity, and belongs to the technical field of pharmaceutics. The chitosan gelatin is prepared through the steps of adding active components having functions of stopping bleeding, resisting bacteria, promoting healing and the like to a non-chemical crosslinking thermo-sensitive bacteria-free water gelatin substrate, wherein under the room-temperature condition, the gelatin being favorable in flowing properties and being in the state of sol is convenient for medication in the uterine cavity, at the physiology temperature of wombs, the gelatin rapidly gelate and is solidified, physical isolation on wound parts after an intrauterine operation is completed, adhesion is avoided, besides, the functions of a biologicalactivity material are exerted, and quick healing of wound parts is promoted. After the wombs are restored, under the physiological action of proliferation and secretion, corrosion and erosion of the gelatin are completed, the gelatin is discharged outside the bodies along with secretion, and human intervention is not needed. The gelatin has the advantages of being simple to apply, capable of predicting effects, free from secondary intervene and the like, and can be used for preventing adhesion after intrauterine operations.