A kind of oral care composition for treating xerostomia and its application

Abstract

The invention discloses an oral care composition for treating xerostomia and the application of the oral care composition. The oral care composition consists of the following components in parts by weight: 0.1-1.5 parts of an olive extract, 0.1-1 part of lactoferrin microspheres and 0.1-5 parts of zinc oxide microspheres. The oral care composition can stimulate saliva secretion, relieve xerostomia, treat gingivitis and alleviate halitosis, can also achieve the effect of artificial saliva, realizes the effect of sterilizing the mouth, facilitates oral health of patients with xerostomia, and can be used for preparing oral care products for treating xerostomia and complication thereof.

Description

technical field

[0001] The invention relates to the technical field of oral medicine and health care, in particular to a treatment technology for xerostomia, in particular to an oral care composition for treating xerostomia and its application. Background technique

[0002] The production and secretion of saliva is critical to oral health and oral function. Due to the role of oral secretions in the colonization area of ​​oral microorganisms, the demineralization ability of teeth is increased, the remineralization ability is reduced, the retention of dentures is reduced, the mucosa is dehydrated and atrophied, and the clearance rate of substances in the oral cavity (including microorganisms and food residues) is reduced. Many complications of xerostomia occur due to the decrease of the effect of antibodies and enzymes in the oral environment, and the decrease of the lubricating effect on oral tissue. Common complications of xerostomia include: dental caries, candidiasis, muc...

Examples

Embodiment 1

[0055] Example 1 Toothpaste

[0056] The toothpaste of the present embodiment, its formula is made up of each component of following parts by weight:

[0057]

[0058]

[0059] The above-mentioned olive extract adopts a commercially available olive extract with an oleuropein content of 10% to 20%.

[0060] The formula of above-mentioned lactoferrin microsphere is made up of each component of following parts by weight:

[0061]

[0062] The above-mentioned core is a commercially available sucrose ball core.

[0063] The above-mentioned PLGA is a polylactic acid-glycolic acid copolymer with a molecular weight of 10,000-100,000.

[0064] The above-mentioned binder is commercially available microcrystalline cellulose.

[0065] The preparation method of above-mentioned lactoferrin microspheres specifically comprises the following steps:

[0066] step 1

[0067] Weigh the amount of deionized water in the recipe, add the binder under stirring conditions and continue sti...

Embodiment 2

[0091] Example 2 Toothpaste

[0092] The toothpaste of the present embodiment, its formula is made up of each component of following parts by weight:

[0093]

Embodiment 1

[0096] Comparative example 1 toothpaste

[0097] The toothpaste of the present embodiment, its formula is made up of each component of following parts by weight:

[0098]

[0099]

[0100] The formula and preparation method of the olive extract and lactoferrin microspheres in this example are the same as in Example 1.

[0101] The preparation method of the toothpaste of this embodiment is the same as that of Example 1 except that zinc oxide microspheres do not need to be added.

technical field

[0001] The invention relates to the technical field of oral medicine and health care, in particular to a treatment technology for xerostomia, in particular to an oral care composition for treating xerostomia and its application. Background technique

[0002] The production and secretion of saliva is critical to oral health and oral function. Due to the role of oral secretions in the colonization area of ​​oral microorganisms, the demineralization ability of teeth is increased, the remineralization ability is reduced, the retention of dentures is reduced, the mucosa is dehydrated and atrophied, and the clearance rate of substances in the oral cavity (including microorganisms and food residues) is reduced. Many complications of xerostomia occur due to the decrease of the effect of antibodies and enzymes in the oral environment, and the decrease of the lubricating effect on oral tissue. Common complications of xerostomia include: dental caries, candidiasis, muc...

Examples

Embodiment 1

[0055] Example 1 Toothpaste

[0056] The toothpaste of the present embodiment, its formula is made up of each component of following parts by weight:

[0057]

[0058]

[0059] The above-mentioned olive extract adopts a commercially available olive extract with an oleuropein content of 10% to 20%.

[0060] The formula of above-mentioned lactoferrin microsphere is made up of each component of following parts by weight:

[0061]

[0062] The above-mentioned core is a commercially available sucrose ball core.

[0063] The above-mentioned PLGA is a polylactic acid-glycolic acid copolymer with a molecular weight of 10,000-100,000.

[0064] The above-mentioned binder is commercially available microcrystalline cellulose.

[0065] The preparation method of above-mentioned lactoferrin microspheres specifically comprises the following steps:

[0066] step 1

[0067] Weigh the amount of deionized water in the recipe, add the binder under stirring conditions and continue sti...

Embodiment 2

[0091] Example 2 Toothpaste

[0092] The toothpaste of the present embodiment, its formula is made up of each component of following parts by weight:

[0093]

Embodiment 1

[0096] Comparative example 1 toothpaste

[0097] The toothpaste of the present embodiment, its formula is made up of each component of following parts by weight:

[0098]

[0099]

[0100] The formula and preparation method of the olive extract and lactoferrin microspheres in this example are the same as in Example 1.

[0101] The preparation method of the toothpaste of this embodiment is the same as that of Example 1 except that zinc oxide microspheres do not need to be added.

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