Triamcinolone acetonide nasal spray with thixotropy and preparation method thereof

A nasal spray and thixotropic technology, applied in the field of pharmaceutical preparations, can solve problems such as uneven drug mixing and poor drug uniformity, and achieve the effects of increasing viscosity, improving stability, and stable performance

Active Publication Date: 2016-11-09
LIAONING UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing triamcinolone acetonide aqueous suspension nasal spray has no thixotropy, white particles precipitate after standing, an

Method used

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  • Triamcinolone acetonide nasal spray with thixotropy and preparation method thereof
  • Triamcinolone acetonide nasal spray with thixotropy and preparation method thereof
  • Triamcinolone acetonide nasal spray with thixotropy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) The formula is as follows

[0026]

[0027] (2) The preparation method is as follows

[0028] 1) Triamcinolone acetonide micronization: Put the triamcinolone acetonide raw material into a jet mill for micronization; particle size: after triamcinolone acetonide micronization, the content of particles with a particle size of less than 15μm is greater than 90%, and the maximum particle size must not exceed 50μm, ready to use after the fineness is qualified.

[0029] 2) Dissolve the prescription amount of compound suspending agent (by weight ratio, microcrystalline cellulose: sodium carboxymethyl cellulose = 89:11) in deionized water (about 60% of the total deionized water), and use High-speed homogenizer, at 12kr / min, high-speed shearing and stirring for 10 minutes, to obtain A;

[0030] 3) Dissolve the prescription amount of Tween-80 in deionized water (approximately 10% of the total deionized water), a part of which is used to disperse the prescription amount of triamcinolo...

Embodiment 2

[0036] (1) The formula is as follows

[0037]

[0038] (2) Preparation method: same as in Example 1.

Embodiment 3

[0040] (1) The formula is as follows

[0041]

[0042] (2) Preparation method: same as in Example 1.

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PUM

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Abstract

The invention relates to a triamcinolone acetonide nasal spray with thixotropy and a preparation method thereof. The triamcinolone acetonide nasal spray is prepared from, by weight, 0.01%-0.1% of triamcinolone acetonide, 0.5%-2.0% of a compound suspending aid, 0.005%-0.01% of a wetting agent, 4%-6% of an osmotic pressure regulator, 0.010%-0.025% of a preservative, 0.001%-0.05% of a complexing agent, a pH regulating agent enabling the system pH to be kept at 4.5 to 5.5 and deionized water. According to the triamcinolone acetonide nasal spray with the thixotropy and the preparation method thereof, the technological process is simple, convenient to operate and reliable, the prepared nasal spray has the thixotropy, the uniformity of the drugs in the suspension preparation is good, and the nasal spray has the good spreadability when the nasal spray is used and is used for treating allergic rhinitis.

Description

Technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a triamcinolone acetonide nasal spray with thixotropy and a preparation method thereof. Background technique [0002] Thixotropy refers to a kind of rheology in which the viscosity or shear force of some systems changes with time under agitation or other mechanical action. Under the action of external shear force, the viscosity of the system decreases with time, and gradually recovers after being stationary. The thixotropic fluid forms a network structure inside the fluid due to the physical agglomeration or electrostatic attraction of the internal molecules. Under the action of external force, the microscopic network structure changes with the shear time, and the macroscopically shows shear thinning Or shear thickening phenomenon. [0003] Triamcinolone acetonide (CAS: 76-25-5) is a potent topical glucocorticoid, the drug of choice for the treatment of seasonal, perennial and allergic ...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K31/58A61K47/38A61K47/18A61K47/14A61K47/26A61P11/02A61P37/08
Inventor 陈烨任翠莹李文军王洋
Owner LIAONING UNIVERSITY
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