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Woodlouse small peptide drug for treating ischemic stroke

A technology for ischemic stroke and ground beetle, which is applied in the direction of drug combination, medical raw materials derived from arthropods, and pharmaceutical formulas. The effect of increasing oxygen supply

Inactive Publication Date: 2016-01-13
ANHUI BIOLOGICAL PEPTIDE IND RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For the treatment of ischemic stroke, at present, both Chinese and Western medicine have basic treatment principles, and under the guidance of the principles, with the further understanding of the etiology and pathology of the disease, many effective treatment methods have been applied in clinical practice. There are new treatments coming out, many of which have shown better results in the laboratory or in individual cases. However, a large-sample, prospective, randomized double-blind study through multi-center collaboration has not yet confirmed which drug or method Can get the best curative effect

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  • Woodlouse small peptide drug for treating ischemic stroke

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Prescription: 90g of ground beetle small peptides, 50g of Panax notoginseng saponins, 90g of kudzu root flavonoids, 70g of angelica volatile oil cyclodextrin inclusion compound

[0063] Preparation method: Preparation of the small peptide of the soil beetle: take the soil beetle, crush it properly, add 10 times the amount of water to homogenate for 10 minutes, heat and boil for 15 minutes, let it cool to room temperature, use hydrochloric acid to adjust the pH to 1.5-2.0, and then add 1% of the substrate pepsin at 40°C for 1 hour, then use sodium hydroxide solution to adjust the pH to 7.5-8.0, add trypsin with 1% substrate, and digest at 40°C for 3 hours. Continue to heat up and boil for 15 minutes, let cool, centrifuge, collect the supernatant, carry out ultrafiltration with a hollow fiber membrane with a relative molecular weight cut-off of 3kD, collect the permeate, concentrate under reduced pressure, and dry to obtain the small peptide of ground beetle; The content ...

Embodiment 2

[0069] Prescription: 90g of ground beetle small peptides, 50g of Panax notoginseng saponins, 90g of kudzu root flavonoids, 70g of angelica volatile oil cyclodextrin inclusion compound

[0070]Preparation method: Preparation of the small peptide of the soil beetle: take the soil beetle, crush it properly, add 10 times the amount of water to homogenate for 10 minutes, heat and boil for 15 minutes, let it cool to room temperature, use hydrochloric acid to adjust the pH to 1.5-2.0, and then add 1% of the substrate pepsin at 40°C for 1 hour, then use sodium hydroxide solution to adjust the pH to 7.5-8.0, add trypsin with 1% substrate, and digest at 40°C for 3 hours. Continue to heat up and boil for 15 minutes, let cool, centrifuge, collect the supernatant, carry out ultrafiltration with a hollow fiber membrane with a relative molecular weight cut-off of 3kD, collect the permeate, concentrate under reduced pressure, and dry to obtain the small peptide of ground beetle; The content o...

Embodiment 3

[0076] Prescription: Wood beetle small peptide 60g, panax notoginseng saponins 50g, kudzu root flavonoids 120g, angelica volatile oil cyclodextrin inclusion compound 70g

[0077] Preparation method: Preparation of the small peptide of the soil beetle: take the soil beetle, crush it properly, add 10 times the amount of water to homogenate for 10 minutes, heat and boil for 15 minutes, let it cool to room temperature, use hydrochloric acid to adjust the pH to 1.5-2.0, and then add 1% of the substrate pepsin at 40°C for 1 hour, then use sodium hydroxide solution to adjust the pH to 7.5-8.0, add trypsin with 1% substrate, and digest at 40°C for 3 hours. Continue to heat up and boil for 15 minutes, let cool, centrifuge, collect the supernatant, carry out ultrafiltration with a hollow fiber membrane with a relative molecular weight cut-off of 3kD, collect the permeate, concentrate under reduced pressure, and dry to obtain the small peptide of ground beetle; The content of small pepti...

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Abstract

The invention discloses a pharmaceutical composition for treating angiocardiopathy, and belongs to the field of traditional Chinese medicine. The pharmaceutical composition for treating the angiocardiopathy is characterized in that traditional Chinese medicine effective parts extracted from woodlice, panax notoginseng, salviae miltiorrhizae and uncaria are matched according to a certain proportion, preparation auxiliary materials are added, and corresponding tablets or capsules are prepared through a conventional method. The pharmaceutical composition for treating the angiocardiopathy has a good effect. According to the clinical application of the drug, the drug is good in effect, low in cost, pure in traditional Chinese medicine preparation and controllable in quality and has a better market prospect.

Description

technical field [0001] The invention relates to a composition of effective parts of traditional Chinese medicine with the effect of treating ischemic stroke and a preparation method thereof, in particular to a composition of effective parts of Chinese medicine extracted from wood beetle, Panax notoginseng, Radix Puerariae and Angelica, and a preparation method thereof, belonging to The field of traditional Chinese medicine. Background technique [0002] Ischemic stroke refers to hemiplegia and disturbance of consciousness caused by cerebral infarction and cerebral artery blockage on the basis of cerebral thrombosis or cerebral thrombosis. It is a common and frequently-occurring disease among middle-aged and elderly people worldwide. With the change of people's living conditions and lifestyles, the incidence of stroke has also shown new trends, one of which is that the incidence is on the rise and the age is getting younger (a clinical data report in Switzerland found that yo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/01A61K35/64A61P9/10A61K36/488
Inventor 刘国飞卢宁代龙
Owner ANHUI BIOLOGICAL PEPTIDE IND RES INST
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