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Composition of effective parts of ground beetle small peptides for treating cardiovascular diseases

A technology of effective parts and ground beetles, which is applied in cardiovascular system diseases, metabolic diseases, drug combinations, etc., can solve the problems of few signs of virus infiltration, long incubation period of cardiovascular diseases, and unclear material basis of drug effects, etc. Bleeding and coagulation time, chemical composition is simple and clear, and the effect of improving microcirculation

Inactive Publication Date: 2016-02-24
山东禹泽药康产业技术研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 2008-2009 "China Cardiovascular Disease Report" pointed out that on average, two out of 10 adults suffer from cardiovascular disease, and one person dies from cardiovascular disease every 10 seconds. During this period, there are often few signs of virus sneaking in, so it is difficult to get enough attention from people before the onset of the disease.
Most of the traditional Chinese medicines currently used are active parts or compound preparations, which contain more chemical components and more complex effects. Therefore, some pharmacological action mechanisms and clinical treatment ranges need further research in order to better guide the use of such traditional Chinese medicines. Clinical medication
[0005] Traditional Chinese medicine exerts medicinal effects through multiple channels, multi-targets, and integrated regulation mechanisms, which has systemic characteristics. However, traditional Chinese medicines have complex chemical components, and the material basis of medicinal effects is not clear, making it difficult to control quality

Method used

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  • Composition of effective parts of ground beetle small peptides for treating cardiovascular diseases

Examples

Experimental program
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Effect test

Embodiment 1

[0065] Prescription: Wood Beetle Peptide 200g, Panax notoginseng Saponins 100g, Salvia Total Phenolic Acids 160g, Uncaria Total Alkaloids 60g

[0066] Preparation method: Preparation of the small peptide of the soil beetle: take the soil beetle, crush it properly, add 10 times the amount of water to homogenate for 10 minutes, heat and boil for 15 minutes, let it cool to room temperature, use hydrochloric acid to adjust the pH to 1.5-2.0, and then add 1% of the substrate pepsin at 40°C for 1 hour, then use sodium hydroxide solution to adjust the pH to 7.5-8.0, add trypsin with 1% substrate, and digest at 40°C for 3 hours. Continue to heat up and boil for 15 minutes, let cool, centrifuge, collect the supernatant, conduct ultrafiltration with a hollow fiber membrane with a molecular weight cut-off of 3kD, collect the permeate, and conduct nanofiltration with a ceramic membrane with a molecular weight cut-off of 150D to 300D. Filter, collect the non-permeated liquid, concentrate u...

Embodiment 2

[0072] Prescription: Wood Beetle Peptide 100g, Panax notoginseng Saponins 50g, Salvia Total Phenolic Acids 80g, Uncaria Total Alkaloids 30g

[0073] Preparation method: Preparation of the small peptide of the soil beetle: take the soil beetle, crush it properly, add 10 times the amount of water to homogenate for 10 minutes, heat and boil for 15 minutes, let it cool to room temperature, use hydrochloric acid to adjust the pH to 1.5-2.0, and then add 1% of the substrate pepsin at 40°C for 1 hour, then use sodium hydroxide solution to adjust the pH to 7.5-8.0, add trypsin with 1% substrate, and digest at 40°C for 3 hours. Continue to heat up and boil for 15 minutes, let cool, centrifuge, collect the supernatant, conduct ultrafiltration with a hollow fiber membrane with a molecular weight cut-off of 3kD, collect the permeate, and conduct nanofiltration with a ceramic membrane with a molecular weight cut-off of 150D to 300D. Filter, collect the non-permeated liquid, concentrate und...

Embodiment 3

[0079] Prescription: Wood Beetle Small Peptide 120g, Panax notoginseng Saponins 30g, Salvia Total Phenolic Acids 80g, Uncaria Total Alkaloids 40g

[0080] Preparation method: Preparation of the small peptide of the soil beetle: take the soil beetle, crush it properly, add 10 times the amount of water to homogenate for 10 minutes, heat and boil for 15 minutes, let it cool to room temperature, use hydrochloric acid to adjust the pH to 1.5-2.0, and then add 1% of the substrate pepsin at 40°C for 1 hour, then use sodium hydroxide solution to adjust the pH to 7.5-8.0, add trypsin with 1% substrate, and digest at 40°C for 3 hours. Continue to heat up and boil for 15 minutes, let cool, centrifuge, collect the supernatant, conduct ultrafiltration with a hollow fiber membrane with a molecular weight cut-off of 3kD, collect the permeate, and conduct nanofiltration with a ceramic membrane with a molecular weight cut-off of 150D to 300D. Filter, collect the non-permeated liquid, concentra...

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Abstract

The invention discloses a composition of effective parts of ground beetle small peptides for treating cardiovascular diseases and belongs to the field of traditional Chinese medicine. The composition is characterized by being prepared into a corresponding dosage form by extracting effective parts from ground beetle, pseudo-ginseng, radix salviae miltiorrhizae and ramulus uncariae cum uncis and adding pharmaceutical adjuncts according to a specific ratio and conventional methods. The composition as a pure traditional Chinese medicine preparation is capable of treating hypertension, hyperviscosity, coronary disease and angina pectoris effectively and is low in raw material cost and exact in treatment effect, thereby being promising in application prospect.

Description

technical field [0001] The invention relates to a composition of effective parts of traditional Chinese medicine for treating cardiovascular diseases and a preparation method thereof, in particular to a composition of effective parts of Chinese medicine extracted from wood beetle, Panax notoginseng, Salvia miltiorrhiza and Uncaria uncaria, and a preparation method thereof, belonging to The field of traditional Chinese medicine. Background technique [0002] Cardiovascular disease, also known as circulatory system disease, is a series of diseases involving the circulatory system. It is a major disease that threatens human health worldwide, and has become the leading cause of death for Chinese adults. One of health problems. Cardiovascular diseases can be subdivided into acute and chronic, and are generally related to arteriosclerosis. The basic symptoms are palpitations, dyspnea, cyanosis, dizziness, and syncope. Common diseases include coronary heart disease, hypertension, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P9/00A61P9/10A61P9/12A61P3/06A61K35/64
Inventor 凌中鑫柏道鸣
Owner 山东禹泽药康产业技术研究院有限公司
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