Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pharmaceutical composition for treating hyperuricemia and preparation method and use of pharmaceutical composition

A technology of hyperuricemia and composition, applied in the field of medicine, which can solve the problems of complicated etiology and disease, difficulty in controlling dosage, insufficient medicine, etc.

Pending Publication Date: 2020-07-07
CHENGDU HUAXI NATURAL MEDICINE
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, high levels of uric acid are harmful, and the etiology and disease are complicated. Currently, allopurinol and febuxostat are commonly used as drugs for lowering blood uric acid, but these drugs have obvious side effects, and the dosage is difficult to control, which can induce gout, etc. The clinical choice of drugs is obviously insufficient

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pharmaceutical composition for treating hyperuricemia and preparation method and use of pharmaceutical composition
  • Pharmaceutical composition for treating hyperuricemia and preparation method and use of pharmaceutical composition
  • Pharmaceutical composition for treating hyperuricemia and preparation method and use of pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Embodiment 1: the preparation of the pharmaceutical composition granule for the treatment of hyperuricemia

[0083] Take 700kg of Qinpi and 500kg of Clematis, soak them in water, add 7-12 times the amount of water to decoct 3 times, each decocting time is 40-100 minutes (collect volatile oil during each decoction), and decoct together Liquid, filtered, concentrated to a relative density of 1.08-1.12, spray-dried to make extract powder, sieved, added dextrin and mixed evenly, and then added sweet substitute sugar and mixed evenly. Add 92% ethanol, sieve, dry at 40-60°C, granulate after sieving, spray into volatile oil, seal and moisten for 65-70 minutes, pack separately, and obtain the pharmaceutical composition granules for treating hyperuricemia.

Embodiment 2

[0084] Embodiment 2: the preparation of the pharmaceutical composition oral liquid for the treatment of hyperuricemia

[0085] Take 700kg of Qinpi and 500kg of Clematis, soak them in water, add 7-12 times the amount of water to decoct 3 times, each decocting time is 40-100 minutes (collect volatile oil during each decoction), and decoct together Liquid, filtered, concentrated to a relative density of 1.08-1.12, added ethanol to make the alcohol content reach 70-80%, let it stand for 24 hours, filtered, and the filtrate was decompressed to recover ethanol and then centrifuged; the supernatant was added to the collected volatile oil and polysorbate Ester, cyclamate and sorbic acid are mixed evenly, added with water, filtered, filled and sterilized to obtain a pharmaceutical composition oral liquid for treating hyperuricemia.

experiment example 3-4

[0086] In the following experimental examples 3-4:

[0087] ①Experimental animals

[0088] Kunming mice (KM), 18-22g, male, SPF grade, provided by Chengdu Dashuo Experimental Animal Co., Ltd.

[0089] SD rats, all male, SPF grade, provided by Chengdu Dashuo Experimental Animal Co., Ltd.

[0090] ②Experimental drugs and reagents

[0091] Potassium oxonate (98%), Shanghai Aladdin Biochemical Technology Co., Ltd. or Shanghai McLean Biochemical Technology Co., Ltd., was prepared with normal saline solution to a concentration of 25 mg / ml before use.

[0092] Yeast extract, Beijing Aobo Biotechnology Co., Ltd., was dissolved in hot water to a solution of 750mg / ml before use.

[0093] Allopurinol, Hefei Jiulian Pharmaceutical Co., Ltd. or Hefei Jiulian Pharmaceutical Co., Ltd., dissolved in hot water to a 2mg / ml solution before use.

[0094] Xanthine oxidase (XOD) test kit, Nanjing Jiancheng Institute of Bioengineering, Jiangsu.

[0095] Total protein quantitative test kit (BCA ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a pharmaceutical composition for treating hyperuricemia. The pharmaceutical composition is prepared from the following components in parts by weight: 500-900 parts of cortex fraxini and 400-600 parts of clematis root. The pharmaceutical composition for treating the hyperuricemia can reduce concentration of blood uric acid in human body.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a pharmaceutical composition for treating hyperuricemia, a preparation method and application thereof. Background technique [0002] Uric acid is a dibasic acid whose pK a1 5.4, ​​pK a2 It is 9.8, and it usually exists as anion in the human body. There are two ways to obtain purine in the human body to synthesize uric acid, one is endogenous purine metabolism to generate uric acid, and the endogenous way is liver, intestinal tract and other tissues, such as muscle, kidney and vascular endothelium through the purine base of the nucleus protein Formed after metabolism, 300-400 mg of uric acid is synthesized every day; one type is exogenous purine to generate uric acid, and the exogenous way is mainly to ingest food containing high purine alkali, and then it is formed after catabolism in the body, and the daily metabolism forms about 300 mg Left and right uric acid. The total uric acid p...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/716A61P19/06
CPCA61K36/63A61K36/716A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P19/06A61K2300/00
Inventor 王曙冯莉
Owner CHENGDU HUAXI NATURAL MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com