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Application of medicinal carbon in preparation of medicaments for curing hyperphosphatemia

A technology of hyperphosphatemia and medicinal charcoal, which is applied in the direction of drug combination, carbon active ingredients, metabolic diseases, etc., and can solve the problems of reducing blood phosphorus in dialysis patients

Inactive Publication Date: 2010-12-08
河北长天药业有限公司
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  • Abstract
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Problems solved by technology

[0005] At present, there is no clinical research data in domestic and foreign literature searches showing that oral medicinal charcoal absorbs phosphorus in the gastrointestinal tract to reduce blood phosphorus in dialysis patients

Method used

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  • Application of medicinal carbon in preparation of medicaments for curing hyperphosphatemia
  • Application of medicinal carbon in preparation of medicaments for curing hyperphosphatemia
  • Application of medicinal carbon in preparation of medicaments for curing hyperphosphatemia

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Embodiment Construction

[0016] Hyperphosphatemia is the central link in the pathophysiology of chronic kidney disease (CKD) mineral and bone disorder (chronickidney disease-mineral and bone disorder (CKD-MBD), and it is also the cause of cardiovascular morbidity and death in CKD patients. independent risk factor. Treatment of hyperphosphatemia mainly includes controlling dietary phosphorus intake, using phosphorus binders to reduce dietary phosphorus absorption, and dialysis to remove phosphorus. Dialysis patients require a high-protein diet in order to prevent malnutrition, and it is difficult to control phosphorus intake. At the same time, there is little residual renal function and the removal of phosphorus by conventional dialysis is limited, so that the incidence of hyperphosphatemia in dialysis patients is higher. Therefore, most dialysis patients need to use phosphorus binders to reduce intestinal absorption of phosphorus. Aluminum salts have not been used routinely in the past 20 years becau...

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Abstract

The invention relates to novel medicinal application of medical carbon, in particular to the application of the medicinal carbon in the preparation of medicaments for curing hyperphosphatemia. In the invention, clinical tests prove that the medicinal carbon, when taken orally, can reduce the serium inorganic phosphorus level and the product of calcium and phosphorus of patients who have received hemodialysis and peritoneal dialysis but do not have the hyperphosphatemia controlled after receiving the treatment by the calcium-containing phosphate binder, and provides a voltage detection (VD) therapy opportunity for patients with secondary hyperparathyroidism which cannot be treated by the VD therapy because of over-high product of calcium and phosphorus. The medical carbon is favorable for reducing and preventing angiocardiopathy development death, caused by chronic kidney disease-mineral and bone disorder (CKD-MBD), of the dialysis patients. Thus, the medicinal carbon can be used as novel medicaments for curing the hyperphosphatemia of patients with dialysis.

Description

technical field [0001] The invention relates to a new medical application of medicinal charcoal, in particular to the application of medicinal charcoal in the preparation of medicines for treating hyperphosphatemia. Background technique [0002] The medicinal properties of medicinal charcoal are adsorption drugs. There are many small pores inside the medicinal charcoal itself, which has a rich micropore structure and a huge surface area of ​​about 1000-3000m 2 / g, according to the van der Hoff principle, it has a strong adsorption effect, and the undissociated alkaloid salts and small water-soluble compounds in the gastrointestinal tract are most likely to be adsorbed, thereby preventing alkaloid poisons from being absorbed by the gastrointestinal tract . Dosage for oral or gavage administration: 50-100g (1-2g / kg) for adults, mixed with 300-400ml of water to form a suspension, orally or poured into the stomach from a gastric tube after gastric lavage, and the dose for child...

Claims

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Application Information

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IPC IPC(8): A61K33/44A61P3/00
Inventor 不公告发明人
Owner 河北长天药业有限公司
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