Composition with effect of preventing and treating complications of dialysis patient, and preparation method and application of composition

A composition and complication technology, applied in the field of biomedicine, can solve the problems of increased preparation process complexity and production costs, hyperkalemia complications, frequent use, etc., to avoid complications or adverse reactions, improve nutritional status, Effects on controlling blood sugar levels

Active Publication Date: 2019-12-06
麦孚营养科技(北京)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] 5. Anemia
But there are following defects: the one, chestnut powder has increased the complexity of preparation technology and production cost; Complications of blood potassium; third, the composition and proportion of nutrients do not meet the requirements of guidelines for kidney disease, making it difficult to comprehensively improve protein energy deficiency, hyperphosphatemia, hyperkalemia, renal hypertension, and postdialysis hypotension in dialysis patients , anemia and other complications
[0017] In summary, the nutritional protein powder disclosed in the prior art for patients with kidney disease and dialysis has many defects: (1) The product mostly uses soybean protein as a raw material, and lacks the high purity, reasonable amino acid composition, high absorption, and high growth rate of whey protein concentrate. (2)

Method used

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  • Composition with effect of preventing and treating complications of dialysis patient, and preparation method and application of composition
  • Composition with effect of preventing and treating complications of dialysis patient, and preparation method and application of composition
  • Composition with effect of preventing and treating complications of dialysis patient, and preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] Example 1 Composition and proportioning research of the composition of the present invention

[0116] Weigh the required amount of raw materials according to Table 1, and mix them uniformly with a mixer to prepare compositions A-R. According to the method described in the present invention, the protein and energy content of the composition A-R is measured, and the blood phosphorus content is detected by the phosphomolybdic acid method, and the blood potassium content is detected by the ion selective electrode method, and the protein energy supply ratio is 10-20%. 7 Group compositions A, B, C, D, J, K, M.

[0117] 140 subjects were selected from patients with kidney disease who underwent hemodialysis three times a week for more than 3 months, and the subjects were aged 32-68 years. 140 patients were randomly divided into 7 groups, 20 cases in each group, there was no significant difference in age, etiology, course of disease, dialysis program, nutritional status, etc. ...

Embodiment 2

[0126] Example 2 Preparation of the composition of the present invention The components and proportions of the compositions 1-3 of the present invention are shown in Table 3.

[0127] Table 3 Components and proportioning ratio of compositions 1-3 of the present invention

[0128] Numbering Whey protein (g) Casein (g) Maltodextrin (g) corn syrup (g) Sunflower oil (g) Composition 1 15 15 15 4 51 Composition 2 23 5 35 6 31 Composition 3 23 5 25 4 43

[0129] Note: The composition of casein (g) used in Table 3 is sodium caseinate: calcium caseinate with a mass ratio of 1:3.5.

[0130] The preparation method of the composition 1-3 of the present invention: take the required amount of whey protein, sodium caseinate, calcium caseinate, maltodextrin, corn syrup and sunflower oil according to Table 3, and mix them evenly with a mixer , that is.

Embodiment 3

[0131] Example 3 Composition of the present invention is used to treat complications of chronic renal failure dialysis patients

[0132] 1. Test patients

[0133] 120 patients with nephropathy who underwent hemodialysis three times a week and had hemodialysis for more than 3 months were selected as test patients. There were 23 cases of episodic glomerulonephritis, 5 cases of hypertensive benign arteriolar nephrosclerosis, 4 cases of aristolochic acid nephropathy and 2 cases of unknown etiology. Among the 120 tested patients, 76% were mildly or moderately malnourished, and 24% were severely malnourished.

[0134] 2. Experimental method

[0135] Each group of patients in the test received treatment guidance, and corresponding symptomatic treatment was given according to the specific conditions of the test patients, including anti-infection, blood sugar control, blood pressure control, and anemia correction. The test patients continued to take the composition of the present ...

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Abstract

The invention provides a composition with the effect of preventing and treating complications of a dialysis patient, and a preparation method and application of the composition. The composition is prepared from the components in parts by mass: 5-33 parts of whey proteins, 1-20 parts of casein or salts of the casein, 1-50 parts of maltodextrin, 1-10 parts of corn syrup and 5-75 parts of sunflower seed oil. The blood potassium level can be controlled to be lower than 5.0 mmol/L, the blood phosphorus level is controlled to be lower than 1.78 mmol/L, the complications such as protein malnutrition,hyperphosphatemia, hyperkalemia and hypertension of the dialysis patient are comprehensively relieved, the dialysis interval time of the dialysis patient is prolonged, and the harm of dialysis to thebody is reduced. In addition, the composition in each unit dose is brewed with 60 mL of water, the liquid intake burden is relieved and is equivalent to the osmotic pressure of the human body, gastrointestinal tolerance is better, and patient compliance is higher.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a composition capable of preventing and treating complications of dialysis patients, a preparation method thereof and an application thereof. Background technique [0002] Dialysis therapy uses hemodialysis and / or peritoneal dialysis to excrete components (such as solutes or water, etc.) in the body fluid of the dialysis patient through a semipermeable membrane. Hemodialysis uses the principle of semi-permeable membranes to expel various harmful metabolites and excess electrolytes from the body through diffusion, purify the patient's blood, correct water, electrolyte and acid-base balance, etc. Peritoneal dialysis uses the peritoneum as a semi-permeable membrane, uses gravity to pour the prepared dialysate into the patient's peritoneal cavity through the catheter, and then constantly replaces the peritoneal dialysate to remove metabolites and toxic substances in the body an...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61P3/12A61P7/06A61P7/08A61P9/02A61P9/12A61K36/28A61K31/718
CPCA61K31/718A61K36/28A61K38/1709A61P3/12A61P7/06A61P7/08A61P9/02A61P9/12A61K2300/00
Inventor 郭伟
Owner 麦孚营养科技(北京)有限公司
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