Total-nutrient formula food suitable for patients with nephropathy and preparation method of total-nutrient formula food

Abstract

The invention discloses a total nutrient formula food suitable for patients with nephropathy and a preparation method thereof. The formula food consists of the following components in percentage by mass: 2-3% of calcium caseinate; 12%-20% of solid starch sugar; 2%-4% of soybean oil, high oleic acid sunflower seed oil and medium chain triglyceride; 3%-5% of mineral substances; 3%-5% of vitamin; 3%-5% of a food additive; 2%-3% of fruit and vegetable powder; and the balance purified water. According to the nutritional requirements of kidney disease patients, protein and electrolyte levels are reasonably designed, the flavor of the product is adjusted, disease progression can be obviously delayed and dialysis time can be delayed when chronic kidney disease non-dialysis patients use the product on the basis of reasonable medication, and the product has excellent nutriology characteristics and patient compliance, and has good clinical application prospects. The nutritional requirements of patients can be met, and the disease progress is delayed.

Description

Technical Field

[0001] The invention belongs to the technical field of special medical formula foods, and in particular relates to a complete nutritional formula food suitable for kidney disease patients and a preparation method thereof. Background Art

[0002] Chronic kidney disease is a chronic progressive disease caused by various reasons, characterized by abnormal kidney structure or function. Chronic kidney disease has a long course, many complications, and a complicated diagnosis and treatment process, which seriously endangers the health of Chinese residents.

[0003] Dietary intervention is recognized as one of the effective and important means of preventing and treating chronic kidney disease at home and abroad. Dietary intervention on the basis of rational medication for non-dialysis patients with chronic kidney disease can significantly delay the progression of the disease and postpone the time to enter dialysis. With the formulation and release of the "National Food Safety Standard General Rules for Special Medical Purpose Formulated Foods" (GB 29922), nutritional support and nutritional intervention have become important means of auxiliary treatment of chronic kidney disease. Special medical purpose kidney disease complete nutritional formula foods are nutritional support products specially designed for the physiological characteristics and nutritional needs of kidney disease patients. my country lacks special medical purpose kidney disease complete nutritional formula foods, and the products are heavily dependent on imports.

[0004] my country urgently needs to break through the key technologies of complete nutritional formula foods for special medical purposes for kidney disease, provide more effective solutions for the clinical treatment of kidney disease patients, and promote the development of my country's national health industry. Summary of the invention

[0005] The purpose of the present invention is to provide a complete nutritional formula food suitable for kidney patients, comprising water, protein, fat, carbohydrates, minerals and vitamins, so as to solve the problems of no special food, poor food flavor and poor compliance for adult non-dialysis chronic kidney patients.

[0006] The complete nutritional formula food suitable for kidney patients is composed of the following components in terms of mass percentage: (1) 2% to 3% calcium caseinate; (2) 12% to 20% solid starch sugar; (3) 2% to 4% soybean oil, high oleic sunflower oil, and medium chain triglycerides; (4) 3‰ to 5‰ minerals; (5) 3‰ to 5‰ vitamins; (6) 3% to 5% food additives; (7) 2% to 3% fruit and vegetable powder; (8) the balance purified water; The minerals are sodium citrate, potassium citrate, magnesium chloride, dipotassium hydrogen phosphate, copper sulfate, potassium iodide, ferrous sulfate, manganese sulfate, sodium selenite, and zinc sulfate; the vitamins are retinyl acetate, cholecalciferol, dl-α-tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, niacinamide, D-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, sodium L-ascorbate, D-biotin, and folic acid; and the food additives are one or more of guar gum, carrageenan, microcrystalline cellulose, sodium carboxymethyl cellulose, gellan gum, sodium pyrophosphate, sodium trimerone, sodium hexametaphosphate, sodium alginate, pectin, phospholipids, mono- and di-glycerol fatty acid esters, and polyglycerol fatty acid esters.

[0007] The energy supply ratio of the formula food is protein: carbohydrate: fat = 5-15: 60-70: 20-30.

[0008] The phosphorus-to-protein ratio of the formula food is 5.6.

[0009] The preparation method of the complete nutritional formula food suitable for kidney patients is as follows: (1) Water phase feeding: Disperse the water phase materials in purified water, dissolve them fully and mix them evenly; (2) Oil phase feeding: Mix the oil phase materials thoroughly and evenly; (3) Pasteurization: After the water phase and the oil phase are mixed, they are heated to 75°C for pasteurization; (4) High-pressure homogenization: After pasteurization, the liquid is homogenized at a pressure of 25 MPa; (5) Filling: Fill the prepared liquid into the packaging container; (6) Sterilization: Place the filled product in a sterilizer for high-temperature sterilization at a temperature of 121°C and an F0 value of 8 to 15 to obtain the finished product.

[0010] The nutritional content of the complete nutritional formula food for kidney patients prepared above is as follows: protein 2.5g / 100mL, fat 2.8g / 100mL, carbohydrate 16g / 100mL, vitamin A 30μg RE / 100mL, vitamin D 1.1μg / 100mL, vitamin E 1mg α-TE / 100mL, vitamin K1 5.5μg / 100mL, vitamin B1 0.1mg / 100mL, vitamin B2 0.1mg / 100mL, vitamin B6 0.1mg / 100mL, vitamin B12 0.16μg / 100mL, niacin 1mg / 100mL, folic acid 28μg / 100mL, pantothenic acid 0.5mg / 100mL, vitamin C7mg / 100mL, biotin 3μg / 100mL, sodium 26mg / 100mL, potassium 26mg / 100mL, copper 55μg / 100mL, magnesium 5mg / 100mL, iron 1.2mg / 100mL, zinc 0.8mg / 100mL, manganese 250μg / 100mL, calcium 70mg / 100mL, phosphorus 14mg / 100mL, iodine 9μg / 100mL, chlorine 140mg / 100mL, selenium 4μg / 100mL.

[0011] The above-prepared complete nutritional formula food suitable for kidney patients is a liquid preparation. Fruit and vegetable powders such as apple and pineapple are added to adjust the flavor of the product.

[0012] The present invention reasonably designs the protein and electrolyte levels and adjusts the product flavor according to the nutritional needs of kidney disease patients. Non-dialysis patients with chronic kidney disease can significantly delay the progression of the disease and postpone the time to enter dialysis by using this product on the basis of reasonable medication. It has excellent nutritional characteristics and patient compliance, can meet the nutritional needs of patients, and delay the progression of the disease.

[0013] The complete nutritional formula food suitable for kidney patients prepared by the present invention has a simple preparation method, easily controllable process conditions, and can ensure the quality, performance and function of the prepared food to be stable. DETAILED DESCRIPTION

[0014] Several preferred embodiments of the present invention are described below, but are not intended to limit the present invention. Example 1

[0015] Product formula: (1) 2g calcium caseinate; (2) 20g solid starch sugar; (3) soybean oil, high oleic sunflower oil, 2g medium chain triglycerides; (4) minerals (sodium citrate, potassium citrate, magnesium chloride, dipotassium hydrogen phosphate, copper sulfate, potassium iodide, ferrous sulfate, manganese sulfate, sodium selenite, zinc sulfate) 0.4g; (5) vitamins (retinyl acetate, cholecalciferol, dl-α-tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, nicotinic acid) (6) Food additives (one or more of guar gum, carrageenan, microcrystalline cellulose, sodium carboxymethyl cellulose, gellan gum, sodium pyrophosphate, sodium trimerone, sodium hexametaphosphate, sodium alginate, pectin, phospholipids, mono- and di-glycerol fatty acid esters, and polyglycerol fatty acid esters) 0.4 g; (7) Fruit and vegetable powder 0.25 g; (8) Make up to 100 mL.

[0016] Step 1, water phase feeding: calcium caseinate, solid starch sugar, minerals (sodium citrate, potassium citrate, magnesium chloride, dipotassium hydrogen phosphate, copper sulfate, potassium iodide, ferrous sulfate, manganese sulfate, sodium selenite, zinc sulfate), vitamins (retinyl acetate, cholecalciferol, dl-α-tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, nicotinamide, D-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, L-sodium ascorbate, D-biotin, folic acid), food additives (guar gum, carrageenan, microcrystalline cellulose, sodium carboxymethyl cellulose, gellan gum, sodium pyrophosphate, sodium trimerionate, sodium hexametaphosphate, sodium alginate, pectin, phospholipids, mono- and di-glycerol fatty acid esters, polyglycerol fatty acid esters, one or more), fruit and vegetable powder, fully dissolved, mixed evenly; Step 2, oil phase feeding: soybean oil, high oleic sunflower oil and medium chain triglycerides are fully mixed; Step 3, pasteurization: after the water phase and the oil phase are mixed, they are heated to 75°C for pasteurization; Step 4, high-pressure homogenization: after pasteurization, the liquid is homogenized at a homogenization pressure of 25 MPa; Step 5: Filling: Fill the prepared liquid into the packaging container; Step 6, sterilization: Place the filled product in a sterilizer for high temperature sterilization at a sterilization temperature of 121°C and an F0 value of 8 to 15 to obtain the finished product. Example 2

[0017] Product formula: (1) 2.5g calcium caseinate; (2) 16g solid starch sugar; (3) soybean oil, high oleic sunflower oil, medium chain triglycerides 2.8g; (4) minerals (sodium citrate, potassium citrate, magnesium chloride, dipotassium hydrogen phosphate, copper sulfate, potassium iodide, ferrous sulfate, manganese sulfate, sodium selenite, zinc sulfate) 0.4g; (5) vitamins (retinyl acetate, cholecalciferol, dl-α-tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, (6) Food additives (one or more of guar gum, carrageenan, microcrystalline cellulose, sodium carboxymethyl cellulose, gellan gum, sodium pyrophosphate, sodium trimerone, sodium hexametaphosphate, sodium alginate, pectin, phospholipids, mono- and di-glycerol fatty acid esters, and polyglycerol fatty acid esters) 0.4 g; (7) Fruit and vegetable powder 0.25 g; (8) Make up to 100 mL.

[0018] Step 1, water phase feeding: calcium caseinate, solid starch sugar, minerals (sodium citrate, potassium citrate, magnesium chloride, dipotassium hydrogen phosphate, copper sulfate, potassium iodide, ferrous sulfate, manganese sulfate, sodium selenite, zinc sulfate), vitamins (retinyl acetate, cholecalciferol, dl-α-tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, nicotinamide, D-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, L-sodium ascorbate, D-biotin, folic acid), food additives (guar gum, carrageenan, microcrystalline cellulose, sodium carboxymethyl cellulose, gellan gum, sodium pyrophosphate, sodium trimerionate, sodium hexametaphosphate, sodium alginate, pectin, phospholipids, mono- and di-glycerol fatty acid esters, polyglycerol fatty acid esters, one or more), fruit and vegetable powder, fully dissolved, mixed evenly; Step 2, oil phase feeding: soybean oil, high oleic sunflower oil and medium chain triglycerides are fully mixed; Step 3, pasteurization: after the water phase and the oil phase are mixed, they are heated to 75°C for pasteurization; Step 4, high-pressure homogenization: after pasteurization, the liquid is homogenized at a homogenization pressure of 25 MPa; Step 5: Filling: Fill the prepared liquid into the packaging container; Step 6, sterilization: Place the filled product in a sterilizer for high temperature sterilization at a sterilization temperature of 121°C and an F0 value of 8 to 15 to obtain the finished product. Example 3

[0019] Product formula: (1) 3g calcium caseinate; (2) 12g solid starch sugar; (3) 4g soybean oil, high oleic sunflower oil, medium chain triglycerides; (4) 0.4g minerals (sodium citrate, potassium citrate, magnesium chloride, dipotassium hydrogen phosphate, copper sulfate, potassium iodide, ferrous sulfate, manganese sulfate, sodium selenite, zinc sulfate); (5) vitamins (retinyl acetate, cholecalciferol, dl-α-tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, nicotinic acid) (6) Food additives (one or more of guar gum, carrageenan, microcrystalline cellulose, sodium carboxymethyl cellulose, gellan gum, sodium pyrophosphate, sodium trimerone, sodium hexametaphosphate, sodium alginate, pectin, phospholipids, mono- and di-glycerol fatty acid esters, and polyglycerol fatty acid esters) 0.4 g; (7) Fruit and vegetable powder 0.25 g; (8) Make up to 100 mL.

[0020] Step 1, water phase feeding: calcium caseinate, solid starch sugar, minerals (sodium citrate, potassium citrate, magnesium chloride, dipotassium hydrogen phosphate, copper sulfate, potassium iodide, ferrous sulfate, manganese sulfate, sodium selenite, zinc sulfate), vitamins (retinyl acetate, cholecalciferol, dl-α-tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, nicotinamide, D-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, L-sodium ascorbate, D-biotin, folic acid), food additives (guar gum, carrageenan, microcrystalline cellulose, sodium carboxymethyl cellulose, gellan gum, sodium pyrophosphate, sodium trimerionate, sodium hexametaphosphate, sodium alginate, pectin, phospholipids, mono- and di-glycerol fatty acid esters, polyglycerol fatty acid esters, one or more), fruit and vegetable powder, fully dissolved, mixed evenly; Step 2, oil phase feeding: soybean oil, high oleic sunflower oil and medium chain triglycerides are fully mixed; Step 3, pasteurization: after the water phase and the oil phase are mixed, they are heated to 75°C for pasteurization; Step 4, high-pressure homogenization: after pasteurization, the liquid is homogenized at a homogenization pressure of 25 MPa; Step 5: Filling: Fill the prepared liquid into the packaging container; Step 6, sterilization: Place the filled product in a sterilizer for high temperature sterilization at a sterilization temperature of 121°C and an F0 value of 8 to 15 to obtain the finished product.

[0021] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A nutritionally complete formula food suitable for patients with kidney disease, characterized in that: The composition is as follows in terms of mass percentage: (1) calcium caseinate 2%~3%; (2) solid starch sugar 12%~20%; (3) soybean oil, high oleic sunflower oil, medium chain triglycerides 2%~4%; (4) minerals 3‰~5‰; (5) vitamins 3‰~5‰; (6) food additives 3%~5%; (7) fruit and vegetable powder 2%~3%; (8) the balance purified water; The minerals are sodium citrate, potassium citrate, magnesium chloride, dipotassium hydrogen phosphate, copper sulfate, potassium iodide, ferrous sulfate, manganese sulfate, sodium selenite, and zinc sulfate; the vitamins are retinyl acetate, cholecalciferol, dl-α-tocopherol acetate, phytonadione, thiamine hydrochloride, riboflavin, niacinamide, D-calcium pantothenate, pyridoxine hydrochloride, cyanocobalamin, sodium L-ascorbate, D-biotin, and folic acid; and the food additives are one or more of guar gum, carrageenan, microcrystalline cellulose, sodium carboxymethyl cellulose, gellan gum, sodium pyrophosphate, sodium trimerone, sodium hexametaphosphate, sodium alginate, pectin, phospholipids, mono- and di-glycerol fatty acid esters, and polyglycerol fatty acid esters.

2. A nutritionally complete formula food suitable for kidney patients as claimed in claim 1, characterized in that: The energy supply ratio of the formula food is protein: carbohydrate: fat = 5-15: 60-70: 20-30.

3. A nutritionally complete formula food suitable for kidney patients as claimed in claim 1, characterized in that: The phosphorus-to-protein ratio of the formula food is 5.

6.

4. The method for preparing a nutritionally complete formula food suitable for kidney patients according to claim 1, characterized in that: The specific steps of the preparation method are as follows: (1) Water phase feeding: Disperse the water phase materials in purified water, dissolve them fully and mix them evenly; (2) Oil phase feeding: Mix the oil phase materials thoroughly and evenly; (3) Pasteurization: After the water phase and the oil phase are mixed, they are heated to 75°C for pasteurization; (4) High-pressure homogenization: After pasteurization, the liquid is homogenized at a pressure of 25 MPa; (5) Filling: Fill the prepared liquid into the packaging container; (6) Sterilization: Place the filled product in a sterilizer for high-temperature sterilization at a temperature of 121°C and an F0 value of 8 to 15 to obtain the finished product.