132results about How to "Improve high blood pressure" patented technology

The present invention relates to novel Pancreatic Polypeptide Family (“PPF”) polypeptides. The PPF polypeptides of the invention generally include at least two PPF motif, have at least 50% sequence identity to PYY (3-36) over its length and will generally retain, at least in part, a biological activity of a PP, PYY or NPY. Preferred PPF polypeptides of the invention are those having a potency in one of the assays described herein (preferably food intake, gastric emptying, pancreatic secretion, or weight reduction assays) which is greater than the potency of PP, NPY, PYY, or PYY(3-36) in that same assay. In one aspect, the PPF polypeptides of the invention include novel PYY analog polypeptides. In another aspect, the PPF polypeptides of the invention include PPF chimeric polypeptides including a fragment of a PP family polypeptide linked to a second PP family polypeptide, wherein each of the first and second fragments includes a PPF motif. Methods of using the PPF polypeptides of the invention, and pharmaceutical compositions including the PPF polypeptides of the invention are also disclosed.

The invention relates to an agent for preventing, improving or treating hypertension, which exhibits a hypotensive effect, inhibits the rise of blood pressure and improves hypertension, and food for preventing or improving hypertension, which does not become a burden in daily intake, has a higher antihypertensive effect and is useful as a diet during treatment for patients of hypertension. The agent for preventing, improving or treating hypertension contains the following components (A) and (B): (A) a compound selected from the group consisting of caffeic acid, chlorogenic acid and ferulic acid, and esters and pharmaceutically acceptable salts thereof; and (B) a component selected from the group consisting of central nervous system stimulating components, food fibers, extracts of perennial evergreen leaves of the genus Camellia, Theaceae, or Eucommia ulmoides Oliver, Eucommiae, organic acids having a molecular weight of 60 to 300 (excluding citric acid) and pharmaceutically acceptable salts thereof, and sugar alcohols.

The invention relates to natural grain-coarse cereal composite nutritional flour and a production method thereof. In recent years, wheat flour eaten by people has single constituent and cannot ensure nutrient balance. Some people try to prepare high-nutrition flour by mixing various coarse cereal flour and wheat, but the prepared flour has low viscosity and cannot improve the appetite of people. High-iron-zinc wheat coarse cereal total nutrient composite flour comprises the following raw materials in part by weight: 60 to 72 parts of high-iron-zinc wheat, 2 to 5 parts of barley, 3 to 5 parts of oats, 5 to 10 parts of buckwheat, 1 to 3 parts of sorghum, 5 to 8 parts of corn, 3 to 4 parts of rice, 1 to 2 parts of millet, 3 to 5 parts of soybean, 1 to 2 parts of peanut, 1 part of yams, 1 part of pea and endotrypsin accounting for 0.5 percent of the weight of the corn, wherein the raw materials are subjected to a certain production process. The composite nutritional flour has the advantages of no chemical additive, reasonable nutrient matching, toughness, better taste and capability of effectively preventing infant apositia and deficiency symptom and remarkably improving cardiovascular and cerebrovascular diseases and hyperlipidemia of middle-aged and elderly people.

The invention discloses a blueberry fish oil capsule, belonging to the field of foods. The blueberry fish oil capsule is health complementary food, each 500mg of products comprises seven ingredients including blueberry extractive, grape seed extractive, marigold extractive, eyebright extractive, soya bean lecithin, wheat-germ oil and fish oil Omega unsaturated fatty acid. The invention is not harmful for the health of human body, and is a health product for the health of eyes.

The invention relates to a nutritional seafood porridge and a processing method thereof, in particular to the processing method of squid which is combined with shrimp meat, scallop, pollution-free vegetables and selected high-quality rice, belonging to the technical field of processing methods of seafood which is combined with vegetables. The nutritional seafood porridge is characterized in that the nutritional seafood porridge comprises the following ingredients of 3 to 5 parts of selected squid chopped meat, 1 to 3 parts of selected fat pork, 1 to 3 parts of selected shrimp meat, 1 to 3 parts of selected scallop, 0.5 to 1 part of vegetable oil, 4 to 6 parts of rice, 10 to 15 parts of water, 5 to 7 parts of pollution-free vegetables and 0.01 to 0.3 part of seasoning according to the mix ratio by weight. The processing method comprises the steps of 1. material selection; 2. thaw and blanching; 3. processing of vegetables; 4. preparing of excipients; 5. vacuum packaging; 6. high-temperature sterilization; 7. cooling; 8. packaging. The processing method can better maintain the original flavor, the nutrients and the values of the squid, the taste is delicious and easy to be stored, the ball soup can be boiled or ready to eat by opening a bag, thereby being characterized by simple operation, energy conversation, long guarantee period, green, health and high nutritional value.

The invention relates to a spicy squid and a processing method thereof, belonging to the technical field of seafood processing methods. The spicy squid is characterized in that the spicy squid contains the following ingredients: 3 to 5 parts of squid tube and head, 1 to 3 parts of vegetable oil, 1 to 2 parts of starch, 1 to 3 parts of pollution-free vegetables, 0.01 to 0.3 part of spice and 0.01 to 0.3 part of edible salt according to the mix ratio by weight. The processing method of the spicy squid is characterized in that the processing method comprises the procedures of 1. material selection, 2. grading and decomposition, 3.blanching and cooling, 4. head plugging, 5. segment cutting, 6. processing of vegetables, 7. preparing of seasoning, 8. soup filling, 9. vacuum packaging, 10. high-temperature sterilization, 11. cooling, 12. packaging. The processing method can better maintain the original flavor, the nutrients and the values of the squid, the taste is delicious and easy to be preserved, thereby being characterized by simpleness, convenience, energy conversation, long guarantee period, green, health and high nutritional value.

The invention discloses a medical probiotics capsule. The filling material comprises active lactobacillus, Tibetan kefir grains, and eurotium cristatum; the active lactobacillus is mainly composed of lactobacillus plantarum, lactobacillus reuteri, lactobacillus acidophilus, lactobacillus casei, and lactobacillus rhamnosus; the contents of Tibetan kefir grains, lactobacillus plantarum, lactobacillus reuteri, lactobacillus acidophilus, lactobacillus casei, and lactobacillus rhamnosus are all more than 60 million / g; and the filling material also comprises proanthocyanidin, propolis, royal jelly, diaphragma juglandis fructus powder, and coenzyme Q10 powder. The capsule comprises a plurality of substances and probiotics, which have a healthcare and curative effect; the raw material sources are wide, the cost is low, the medicinal effect is unique; and the capsule has the functions of reducing blood fat, regulating blood pressure, helping sleep, maintaining beauty, delaying aging, nourishing stomach, and purging gut, and also has a certain curative effect on cancer and diabetes.

The invention discloses a compound gingko health product solid preparation which is prepared by mixing ginkgo leaf extract, salvia miltiorrhiza bunge, American ginseng, seabuckthorn flavone and gelatin or an enteric substrate. The compound gingko health product solid preparation comprises the following effective components in parts by weight: 1-60 parts of ginkgo leaf extract, 1-60 parts of salvia miltiorrhiza bunge, 1-30 parts of American ginseng and 0.5-20 parts of seabuckthorn flavone. The gingko, the salvia miltiorrhiza bunge, the American ginseng and the seabuckthorn flavone are comprehensively mixed to achieve the effects of convenient use and comprehensive nourishing. The health product of the compound gingko health product solid preparation has values as both food and medicine and can be used by a patient with a cerebral-vascular disease and a patient with higher blood fat and used for resisting cancer, resisting fatigue, resisting anoxia, resisting radiation, resisting aging, strengthening immunity, and the like by a healthy person. The compound gingko health product solid preparation mainly has two formulations of pills and soft capsules, is convenient for use, is beneficial to absorption and meets the requirement on health by wide consumers.

The invention provides Corydalis edulis extract, prepared by a method comprising the following steps: (1), after crushing a Corydalis edulis plant, and extracting with alkaline ethyl alcohol or methyl alcohol to obtain an extract; (2), subjecting the extract obtained in step (1) to normal pressure or vacuum concentration to obtain concrete, or spray drying to obtain powder; (3), adding an acid solution into the concrete or powder obtained in step (2), filtering to obtain an acid aqueous solution, adding an alkaline solution to the acid aqueous solution to obtain an alkali treated solution; (4), adding an organic solvent to the alkali treated solution obtained in step (3), vacuum recycling the organic solvent after extracting to obtain Corydalis edulis total alkaloids crude extract. The Corydalis edulis extract or a pharmaceutical composition containing the extract can be used to prepare pharmaceuticals for preventing and / or treating diseases caused by glucose and lipid metabolism disorder.

The invention discloses a preparing method of health honey vinegar bean. The preparing method includes the steps of preparing water extracts of cibot rhizome, Cherokee rose fruit, rehmannia rhizome, prepared rehmannia rhizome, Indian bread, mulberry and fleeceflower root; subjecting the extracts of vinegar, the cibot rhizome, the Cherokee rose fruit, the rehmannia rhizome, the prepared rehmannia rhizome, the Indian bread, the mulberry and the fleeceflower root to nine times of steaming and soaking; and finally, performing drying and packaging to obtain the health honey vinegar bean. The health honey vinegar bean prepared by the preparing method is as effective as various food materials having the hair blacking effect; consumers can eat the health honey vinegar bean with no limitations on time, location and manner, the traditional eating method where the different herbal materials need to be decocted or consumed many times is changed, the needs of the consumers for convenience of carrying the health honey vinegar bean, ease and quickness of eating and taste diversity are met, the need for dietary health care is more conveniently met, and the health honey vinegar bean allows dietary health care for more people.

The invention discloses application of umbilical cord mesenchymal stem cell-derived exosome in preparing drug or preparation for treating preeclampsia, in particular relates to application of treating preeclampsia by extracting exosome through umbilical cord mesenchymal stem cells of humans. The exosome can effectively alleviate hypertension and proteinuria of preeclampsia and glomerulonephritis, reduce inflammatory response in placenta, and promote fetal development. This kind of exosome has the advantages of convenience in storage and transport and provides a new strategy for treating related diseases of refractory inflammations of preeclampsia.

The invention provides lignum aquilariae resinatum extract. The lignum aquilariae resinatum extract is characterized in that the lignum aquilariae resinatum extract is prepared by the aid of a method including steps of (1), smashing lignum aquilariae resinatum and extracting the lignum aquilariae resinatum by the aid of methanol or ethanol aqueous solution to obtain extract liquid; (2), concentrating and drying the extract liquid obtained in the step (1) under normal pressures or reduced pressures to obtain extract cream, or carrying out spray-drying on the extract liquid to obtain powder, then dissolving the extract cream or the powder in water to obtain solution, extracting the solution by the aid of petroleum ether to obtain petroleum ether extract liquid, and extracting aqueous layers by the aid of ethyl acetate to obtain ethyl acetate extract liquid; (3), concentrating and drying the ethyl acetate extract liquid obtained in the step (2) under reduced pressures to obtain extract cream, or carrying out spray-drying on the ethyl acetate extract liquid to obtain powder. The lignum aquilariae resinatum extract and the method have the advantage that the lignum aquilariae resinatum extract or a pharmaceutical composition with the lignum aquilariae resinatum extract can be used for preparing medicines for preventing and / or treating diseases due to glucose and lipid metabolism disorder.

The invention provides a method for preparing a pseudo-ginseng flower extract, which comprises the following steps of: extracting by using solution of water and ethanol, adding water after concentration, feeding in a macroporous resin column, collecting ethanol elution liquid, concentrating and drying, and the like. The total saponin content in the obtained pseudo-ginseng flower extract is 50 to 95 percent. The extraction and purification method has simple and convenient conditions, and is favorable for industrialized popularization and application.

A seaweed-soybean milk powder is prepared from seaweed product and instant soybean milk powder through proportionally, mixing, sterilizing and packaging. The said seaweed product is prepared from fresh or dried seaweed through removing impurities and deodoring, dewatering, baking, flavouring and cutting. its advantages are unique taste and enjoyment to eat it, rich trace elements and edible fibres, and high nutrient value.

The invention discloses a processing method for comprehensively utilizing kudzuvine root. The processing method for comprehensively utilizing kudzu vine root is characterized by comprising the following steps: soaking taken fresh kudzuvine root in water and washing cleanly; feeding the cleaned fresh kudzuvine root to a crusher to crush, then filtering the kudzuvine root through a 120-mesh sieve to obtain a kudzuvine root pulp solution under the sieve and kudzuvine root solid matter on the sieve; dewatering the kudzuvine root solid matter on the sieve under the pressure being 0.8-1.2 MPa, conveying the dewatered kudzuvine root solid matter to an air flow dryer, instantly drying the kudzuvine root solid matter to obtain kudzuvine root fiber powder, and carrying out superfine grinding to prepare superfine kudzuvine root powder; then taking down the kudzuvine root pulp solution under the sieve, filtering the kudzuvine root pulp solution through a 120-mesh filtration screen, pumping kudzuvine root starch pulp solution to a rotational flow sand remover, then feeding the kudzuvine root starch pulp solution into a disc separator to concentrate, standing and then taking out upper kudzuvine root clear liquid, concentrating the upper kudzuvine root clear liquid in vacuum, then mixing, homogenizing, filling and carrying out pasteurization to prepare kudzuvine root essence liquid. By adopting the processing method for comprehensively utilizing kudzuvine root, the kudzuvine root is comprehensively utilized, so that clean production is achieved.

The invention provides a neck guard and blood pressure reducing drug pillow which comprises a pillowcase and a drug pillow core composed of Chinese medicinal herbs. The drug pillow core comprises, by weight, 41%-43% of alums, 41%-43% of semen cassiae, 0.8%-1% of chrysanthemum, 0.8%-1% of scutellaria baicalensis, 0.8%-1% of uncaria rhynchophylla, 0.8%-1% of gastrodia elata, 0.8%-1% of dogbane leaves, 0.8%-1% of loranthus parasiticus, 0.8%-1% of kudzuvine roots, 0.8%-1% of ligusticum wallichii, 0.8%-1% of monkshood, 0.8%-1% of radix aconiti kusnezoffii, 0.8%-1% of caulis spatholobi, 0.8%-1% of Chinese angelica, 0.8%-1% of hairyvein agrimony, 0.8%-1% of cassia twig, 0.8%-1% of safflower carthamus, 0.8%-1% of radix angelicae and 0.8%-1% of hematoxylon. According to the neck guard and blood pressure reducing drug pillow, traditional Chinese medicine external permeation is adopted, the Chinese traditional Chinese medicines are guided by a manner of pathfinding, and the medicines do not directly enter a human body. The drug pillow can be used for a long time, is safe, and has no side effects. High blood pressure and cervical spondylosis can be obviously improved through a clinical test, and especially has an obvious effect on a user only with the high blood pressure.

The invention discloses a herba elsholtziae-containing traditional Chinese medicine composition for lowering lipid. The traditional Chinese medicine composition comprises the following components in parts by weight: 35-45 parts of herba elsholtziae, 25-35 parts of lotus leaf, 22-28 parts of poria cocos, 28-32 parts of fructus cannabis, 22-28 parts of Chinese yam, 22-28 parts of hawthorn, 8-12 parts of pogostemon cablin and 12-18 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention is used for removing dampness and clearing away turbidness by tonifying the spleen, regulating the organism balance as a whole, inhibiting lipid absorption, accelerating lipolysis and promoting excretion, so as to lower blood fat; and the components are all 'medicine food homology' varieties, so that the traditional Chinese medicine composition is safe and free of a toxic or side effect, and can be taken for a long period of time.

The invention discloses akebiaquinata health-care tea and a preparation method thereof. The akebiaquinata health-care tea contains the following raw materials in parts by weight of dried product: 10 parts of akebia trifoliate peel, 0.5-1 part of orange peel, 0.5-1 part of mango skin, 0.5-1 part of dragon fruit skin, 0.5-1 part of tea leaves, 0.5-1 part of honeysuckle, 0.5-1 part of snow chrysanthemums and 0.5-1 part of rose. The preparation method comprises the following steps: 1, picking fresh akebia trifoliate peel, orange peel, mango skin and dragon fruit skin, slicing the peel and skin into blocks, and picking fresh tea leaves; 2, fermenting the four kinds of peel and tea leaves; 3, drying the fermented materials so as to reduce the moisture content to be 8-10 percent, and thus obtaining initial tea; 4, adding dried honeysuckle, snow chrysanthemums and rose into the initial tea according to a design ratio, and stirring to be uniform to obtain the finished product. After being drunk frequently, the akebiaquinata health-care tea can effectively improve sub-health conditions of the human body and has the effects of nourishing yin and tonifying kidney, invigorating the stomach and beautifying and treating diseases such as hypertension, hyperlipidemia, hyperglycemia, frequent micturition and lactation promotion in an assisted mode.

The present invention relates to methods, kits and compositions to treat hypertension and other cardiovascular diseases in a subject, in particular, a method of treating or preventing a cardiovascular disease in a subject comprising administering to a subject at least one anti-miR agent to miRNA-425. In some embodiments, an anti-miR agent is a small molecule or an oligonucleotide complementary to at least part of the miR-425 of SEQ ID NO: 1, or an anti-miR complementary to at least part of the miRNA seed sequence AUGACA (SEQ ID NO: 2). Another aspect of the present invention relates to methods, kits and compositions to treat low blood pressure in a subject comprising administering a composition comprising a miR-425 agent to decrease ANP levels in the subject. Other aspects of the present invention relates to assays, methods and systems to identify a subject at risk of hypertension, or identifying a subject suitable to administration of an anti-miR-425 agent for treatment of hypertension, the assay comprising assessing if a subject is homozygous or heterozygous for the major (A) allele of rs5068 SNP, and / or assaying for levels of miR-425 and / or assaying for levels of NT-proANP and / or levels of ANP in the plasma of a subject.

The invention relates to a Chinese medicinal composition which comprises the constituents of male silkworm moth, epimeddium, dodder seed, wolferry fruit, Chinese caterpillar fungus, broomrape, rhodiola root, astragalus root, prepared rehmannia root and safflower, and can be prepared into dosage forms of oral liquid, tinctures, granules, capsules, tablets, soft capsules, pills, liquid capsules, preferably tinctures. The invention also discloses the process for preparing the Chinese medicinal composition and its quality control method.

The invention discloses dumplings with effects of decreasing blood pressure and blood lipid. The dumplings comprise dumpling wrapper and dumpling stuffing, wherein the dumpling wrapper comprises the following raw materials in parts by weight: 10-12 parts of buckwheat tea leaves, 300-400 parts of water and 500-600 parts of flour; the dumpling stuffing comprises the following raw materials in parts by weight: 80-100 parts of fresh altemanthera tender buds, 9-12 parts of apricot, 30-50 parts of kelp, 30-50 parts of black fungus, 80-100 parts of carp meat, 10-20 parts of mushrooms, 20-30 parts of fresh hawthorn and 20-30 parts of fresh Chinese yam; and the dumpling stuffing also comprises the following raw materials in parts by weight: 20-30 parts of oil, 2-4 parts of salt, 1-2 parts of monosodium glutamate, 1-2 parts of five spice powder, 5-9 parts of green onion, 5-9 parts of ginger and 3-4 parts of cooking wine. The dumplings disclosed by the invention can achieve the effects of decreasing blood pressure and blood lipid, is delicious in taste and can treat hypertension and hyperlipidemia in an assisted mode.

The invention discloses a medicine which is prepared by the Chinese herbs with the functions of clearing away the heart fire and eliminating phlegm, sedation and decompression and is used for treating high blood pressure. The medicine is a refined external-use compound paste prepared by the effective ingredients of Radix Stephaniae Tetrandrae, Radix Astragali, Radix Rehmanniae Preparata, Rhizoma Diosscoreae, Fructus Corni, Rhizoma Alismatis, Radix Paeoniae Alba, Poria, Cortex Moutan, Radix Salviae Miltiorrhizae and Euonymus alatus. The invention has evident effect on decompression, sedation and diuresis. The paste body of the plaster is fine, soft and smooth, easy to be coated on cloth and uneasy to melt, easy for carrying and use because of small size, and good for quick recovery of focus. The poultice has stable drug property and has the characteristics of quick percutaneous absorption, good ventilation property and gradual drug releasing. Compared with the oral preparation, the invention has the advantages of no liver-intestines first-filter action, no influence from gastrointestinal degradation and high bioavailability. Compared with injection, the invention has the advantages of convenient use and no pain. Compared with ointment, the invention has the advantages of accurate dose and fixed absorption area. Compared with black plaster and sticking plaster, the invention has the advantages of no sensibility on skin, no pollution to clothes, long effect, percutaneous absorption and convenient carrying and use.

The invention relates to a blood sugar and blood fat-reducing health-care effervescent preparation. The calcium-supplementing effervescent preparation is prepared from the following raw materials: 5 to 30 parts of tartary buckwheat flour, 5 to 15 parts of full bitter gourd powder, 1 to 2 parts of black fungus powder and the like. The preparation has multiple health-care effects of reducing blood sugar and blood fat, strengthening human immunity, treating gastric disease, dehumidifying and the like, is particularly low in relative cost because the raw materials are common, belongs to food therapy and can be eaten by most of diabetes crowds as well as hypertension and hyperlipidemia crowds for a long time.

The invention discloses capsules with dendrobium officinale and fish oil and belongs to the field of foods. The capsules are a healthy and supplementary food and are prepared by adopting main materials and other auxiliary materials such as gelatin, wherein the main materials are as follows (by weight): 10-20mg of dendrobium officinale extract, 95-105mg of grape-seed extract, 20-25mg of marigold extract, 10-15mg of wolfberry extract, 7-9mg of carotene, 2.5-3.5mg of sunflower seed oil and 300-320mg of fish oil. The capsules are safe and hazard-free to a human body and can be used as a health-care product in the aspect of eye health.

The invention discloses an edible blend oil for prevention and treatment of pre-diabetes, and belongs to the field of blend oil manufacturing technology. The edible blend oil for prevention and treatment of pre-diabetes includes the following ingredients: soybean oil, olive oil, seal oil, omega-3 fatty acid, omega-6 fatty acid, essential amino acid, fat-soluble vitamin, water-soluble vitamin, trace element, fructose, glucose, carotene, chlorophyll, etc. The edible blend oil for prevention and treatment of pre-diabetes provided by the invention can replace traditional peanut oil for eating. Theedible blend oil for prevention and treatment of pre-diabetes contains a variety of beneficial ingredients, has more balanced nutrition, and contains a large number of linoleic acid, linolenic acid and unsaturated acid, alpha-linolenic acid, olive polyphenols, etc. The edible blend oil for prevention and treatment of pre-diabetes is low in cholesterol content and good for patients with hyperlipemia, hypertension, hyperglycemia, obesity and cardiovascular and cerebrovascular diseases after long-term consumption. The edible blend oil for prevention and treatment of pre-diabetes has good antioxidant and free radical scavenging abilities, and the edible blend oil is beneficial to the prevention of diabetic cardiovascular diseases and good in blood sugar lowering effect.

The invention provides compositions and methods for prevention, treatment, or management of pulmonary hypertension using piperidine, pyrrolidine, or azepane derivatives comprising one to four nitric oxide (NO) donor groups and a reactive oxygen species (ROS) degradation catalyst. The invention further provides a water dispersible powder comprising nanoparticles comprising said derivatives, as well as pharmaceutical compositions thereof and methods of use.

The invention belongs to the technical field of the production of health products and in particular to a production process of trifoliate orange Cherokee rose capsules. The production process mainly comprises the following steps: washing, removing pits, selecting, cleaning, drying in the air, hulling, drying over a fire, synthesizing, grinding and filling. The trifoliate orange Cherokee rose capsules are natural, cheap and suitable for the young and the old.

The invention relates to an anion health preserving perspiration steaming vat. The anion health preserving perspiration steaming vat comprises a health preserving vat body and a fumigating and mixingdevice, wherein the health preserving vat body is connected with the fumigating and mixing device through a steam duct; the health preserving vat body and the fumigating and mixing device are connected with a power source control system; and the health preserving vat body comprises a vat body, a vat door, a ceramic bench and a base plate. According to the anion health preserving perspiration steaming vat disclosed by the invention, hydrosphere, oxygen and electromagnetization are comprehensively and integrally mixed; an oxygen increasing efflux unit rotates clockwise, and a steam current is incirculation rotation from bottom to top; a medicine adding hole is formed, liquid medicines mixed with hydrosphere and oxygen are subjected to electromagnetization, and enter the health preserving vat body to form micro cluster water of which the diameter is 0.5-0.8 nanometer, and then the micro cluster water enters the human body, so that various kinds of chronic diseases including skin diseases, joint diseases, hypertension, stroke sequela and the like can be effectively improved, and metabolism is enhanced; and the anion health preserving perspiration steaming vat can release anions, so that the excretion of metabolite is accelerated, and the metabolism of fat, uric acid and blood glucose is accelerated.