Compound microbial preparation for treating diabetes, preparation method thereof and application thereof

A technology of compounding microorganisms and preparations, applied in the biological field, can solve the problems of not specifying the mixing ratio of the three kinds of bacteria, the clinical efficacy is yet to be evaluated, and the effect of Chinese patent medicines in reducing blood sugar is slow, so as to eliminate diabetes and complications, and improve the body's immunity. , Improve the effect of microcirculation perfusion

Active Publication Date: 2010-05-12
葫芦岛农村商业银行股份有限公司兴城支行
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Western medicines are expensive to treat diabetes, have high toxic and side effects, and treat the symptoms but not the root cause; Chinese patent medicines are slow in reducing blood sugar and take a long time; biotechnology can overcome the shortcomings of the above two
Chinese patent 99105621 "biological hypoglycemic agent" is a single bacterial species, and its therapeutic effect is relatively single; the medicine of Chinese patent 00804999 is an enzyme preparation used for auxiliary treatment of diabetes; It is composed of three kinds of microorganisms, lactic acid bacteria and yeast, but it is only a simple mixture, and the mixing ratio of the three kinds of bacteria is not specified, and there is no certain amount of clinical verification, and its clinical efficacy is yet to be evaluated

Method used

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  • Compound microbial preparation for treating diabetes, preparation method thereof and application thereof
  • Compound microbial preparation for treating diabetes, preparation method thereof and application thereof
  • Compound microbial preparation for treating diabetes, preparation method thereof and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] The preparation method of embodiment 1 composite microbial preparation

[0041] First-level compound fermentation:

[0042] (1) Take 300ml each of Rhodopseudomonas palustris, Bacillus subtilis, Saccharomyces cerevisiae, Lactobacillus acidophilus and Streptomyces jingyangensis each 300ml, and inoculate them in 60L primary medium of each strain for primary culture , to obtain the primary strains of each component;

[0043] (2) Take 60L each of the primary strains of Rhodopseudomonas palustris, Bacillus subtilis, Saccharomyces cerevisiae, Lactobacillus acidophilus, and Streptomyces jingyang, and inoculate them in 600L of the secondary culture medium of each strain for secondary Cultivate to obtain the fermentation broth of each component;

[0044] (3) the fermentation broth of each component is in 1000L stock solution by the ratio of Rhodopseudomonas palustris 10%, Bacillus subtilis 10%, Saccharomyces cerevisiae 30%, Lactobacillus acidophilus 45%, Streptomyces jingyang 5...

Embodiment 2

[0048] The preparation method of embodiment 2 compound microbial preparations

[0049] First-level compound fermentation:

[0050] (1) Take 500ml each of Rhodopseudomonas palustris, Bacillus subtilis, Saccharomyces cerevisiae, Lactobacillus acidophilus, and Streptomyces jingyangensis, and inoculate them in 60L primary medium of each strain for primary culture , to obtain the primary strains of each component;

[0051] (2) Take 60L each of the primary strains of Rhodopseudomonas palustris, Bacillus subtilis, Saccharomyces cerevisiae, Lactobacillus acidophilus, and Streptomyces jingyang, and inoculate them in 600L of the secondary culture medium of each strain for secondary Cultivate to obtain the fermentation broth of each component;

[0052] (3) the fermented bacterium liquid of each component is in 1000L stock solution by the ratio of Rhodopseudomonas palustris 5%, Bacillus subtilis 14%, Saccharomyces cerevisiae 32%, Lactobacillus acidophilus 41%, Streptomyces jingyang 8% ...

Embodiment 3

[0056] The preparation method of embodiment 3 composite microbial preparations

[0057] First-level compound fermentation:

[0058] (1) Take 600ml each of Rhodopseudomonas palustris, Bacillus subtilis, Saccharomyces cerevisiae, Lactobacillus acidophilus and Streptomyces jingyangensis each 600ml, and inoculate them in 60L primary medium of each strain for primary culture , to obtain the primary strains of each component;

[0059] (2) Take 60L each of the primary strains of Rhodopseudomonas palustris, Bacillus subtilis, Saccharomyces cerevisiae, Lactobacillus acidophilus, and Streptomyces jingyang, and inoculate them in 600L of the secondary culture medium of each strain for secondary Cultivate to obtain the fermentation broth of each component;

[0060] (3) the fermented bacterium liquid of each component is in 1000L stock solution by the ratio of Rhodopseudomonas palustris 8%, Bacillus subtilis 12%, Saccharomyces cerevisiae 35%, Lactobacillus acidophilus 42%, Streptomyces Ji...

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Abstract

The invention relates to a compound microbial preparation for treating diabetes, which comprises the following components in percentage by volume: 5 to 15 percent of photosynthetic bacteria, 10 to 20 percent of bacillus, 20 to 35 percent of yeast, 30 to 45 percent of lactobacillus and 3 to 10 percent of actinomycetes. The invention also relates to a preparation method of the compound microbial preparation and application thereof in preparation of a medicament for treating the diabetes. The preparation method comprises the steps of one-step compound fermentation and two-step compound fermentation of strains. The compound microbial preparation has low preparation cost, quick action and good mouthfeel, does not need diet control during application, and can address root causes and symptoms.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a compound microbial preparation, a preparation method thereof and an application in preparation of medicines for treating diabetes. Background technique [0002] Diabetes is a common, multiple, and lifelong disease caused by an inappropriate increase in blood glucose (a simple sugar) level due to the inability of the body to release or utilize insulin normally. According to the World Health Organization (WTO) survey, the number of diabetics in the world is as high as 160 million, and there are more than 60 million diabetics in China, accounting for 1 / 3 of the global number of diabetics. According to statistics, blindness caused by diabetes is 10 more than the average person. -23 times; gangrene and amputation are 20 times more than the average person; kidney failure is 17 times more than the average person; coronary heart disease and stroke are 2-3 times more than the av...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/064A61P3/10C12N1/18C12N1/20A61K35/74
CPCA61K36/06A61K2035/115A61K35/747A61K35/742A61K35/74A61K36/064C12N1/20C12N1/18A61P3/10A61K2300/00
Inventor 王立平
Owner 葫芦岛农村商业银行股份有限公司兴城支行
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