The invention discloses a composition with a health-care function as well as a preparation method and application thereof. The composition is prepared from tea flowers, illicium verum, smoked plums, fructus cannabis, liquorice, fingered citron, sea-buckthorn, houttuynia cordata, momordica grosvenori, scaphium scaphigerum, chrysanthemum, platycodon grandiflorum, the root of kudzu vine, dandelion, mint, orange peel, laurel, clove, selfheal, astragalus sinicus pollen and green tea leaves. The invention further provides application of the composition. The composition is used for preparing an external atomization spray. The invention also provides a preparation method of the external atomization spray. The composition provided by the invention can be prepared into the medical and edible dual-purpose spray with the medical health-care function, can effectively kill most of viruses and bacteria, and has the effects of resisting inflammation and bacteria, diminishing inflammation and relieving pain, moistening lung to arrest cough, clearing lung and reducing phlegm, detoxifying, inhibiting bacteria, reducing blood sugar, delaying senescence, preventing and resisting cancer, enhancing immunity, warming yang and dispelling cold, stopping ulceration and hematoma and the like.