The invention discloses a preparation process of a slurry for high-efficiency drilling of a steep drainage clastic rock stratum. Various components added in slurry are optimized, corresponding proportional relations are adjusted, and the slurry is prepared by adopting different proportions aiming at working areas with the characteristics of many conglomerate layers, poor cementation, sand-mud interbedding, thick layers and steep drainage of the stratum. The slurry is prepared by adjusting the drilling depth: a coarse dispersion low-solid-phase mud system is adopted for a drilled hole with thedesigned depth within 400 m; and for a drill hole with the design depth larger than 400 m, a film-forming wall-protecting low-solid-phase mud system is adopted. Materials used in the invention comprise sodium bentonite, an anti-collapse while-drilling plugging agent, potassium chloride, a tackifier, a film forming agent B, modified asphalt and a fluid loss agent, and can also comprise high-viscosity cellulose, a high-efficiency lubricant and a coating agent. By the adoption of the slurry, high-efficiyenc drilling in the abrupt clastic rock stratum of a certain uranium mine area is achieved, and the engineering problems of hole leakage, chipping, hole collapse, hole shrinkage and the like are avoided.